Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Emma L Rawlins"'
Autor:
Dawei Sun, Lewis Evans, Francesca Perrone, Vanesa Sokleva, Kyungtae Lim, Saba Rezakhani, Matthias Lutolf, Matthias Zilbauer, Emma L Rawlins
Publikováno v:
eLife, Vol 10 (2021)
Human organoid systems recapitulate key features of organs offering platforms for modelling developmental biology and disease. Tissue-derived organoids have been widely used to study the impact of extrinsic niche factors on stem cells. However, they
Externí odkaz:
https://doaj.org/article/94a700ff207d48a3bc0ed257b016de58
Autor:
Marko Z Nikolić, Oriol Caritg, Quitz Jeng, Jo-Anne Johnson, Dawei Sun, Kate J Howell, Jane L Brady, Usua Laresgoiti, George Allen, Richard Butler, Matthias Zilbauer, Adam Giangreco, Emma L Rawlins
Publikováno v:
eLife, Vol 6 (2017)
The embryonic mouse lung is a widely used substitute for human lung development. For example, attempts to differentiate human pluripotent stem cells to lung epithelium rely on passing through progenitor states that have only been described in mouse.
Externí odkaz:
https://doaj.org/article/3df32384189b4023bea988a27a860988
Autor:
Marko Z Nikolić, Emma L Rawlins
Publikováno v:
eLife, Vol 5 (2016)
Transplanting bioengineered human lung organoids into mice could lead to a humanized model for pre-clinical studies of lung disease.
Externí odkaz:
https://doaj.org/article/e9dd0bedb5634ec18ce13a9d3058b384
Autor:
Marta Vilà-González, Laetitia Pinte, Ricardo Fradique, Erika Causa, Heleen Kool, Mayuree Rodrat, Carola Maria Morell, Maha Al-Thani, Linsey Porter, Wenrui Guo, Ruhina Maeshima, Stephen L. Hart, Frank McCaughan, Alessandra Granata, David N. Sheppard, R. Andres Floto, Emma L. Rawlins, Pietro Cicuta, Ludovic Vallier
Publikováno v:
Respiratory Research, Vol 25, Iss 1, Pp 1-13 (2024)
Abstract Background Pulmonary ionocytes have been identified in the airway epithelium as a small population of ion transporting cells expressing high levels of CFTR (cystic fibrosis transmembrane conductance regulator), the gene mutated in cystic fib
Externí odkaz:
https://doaj.org/article/6ef9e41560be48c89f72cdcceb53767c
Autor:
Ming-Hsuan Wen, Hector Barbosa Triana, Richard Butler, Hsiang-Wei Hu, Yang-Hong Dai, Nicola Lawrence, Jun-Jie Hong, Nigel Garrett, Rue Jones-Green, Emma L. Rawlins, Ziqi Dong, Magdalena J. Koziol, J. B. Gurdon
Publikováno v:
Biology Open, Vol 13, Iss 3 (2024)
Externí odkaz:
https://doaj.org/article/47b33700eb6c4367a25ce9fdc809b4e4
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2023)
Organoids have become a prominent model system in pulmonary research. The ability to establish organoid cultures directly from patient tissue has expanded the repertoire of physiologically relevant preclinical model systems. In addition to their deri
Externí odkaz:
https://doaj.org/article/b651e0950c3b4330b130e47cf7e32e44
Multipotent epithelial progenitor cells can be expanded from human embryonic lungs as organoids. and maintained in a self-renewing state using a defined medium. The organoid cells are columnar, resembling the cell morphology of the developing lung ti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5d9c4976e2e03340fc93c6507dbd73d
Autor:
Laura Wagstaff, Maja Goschorska, Kasia Kozyrska, Guillaume Duclos, Iwo Kucinski, Anatole Chessel, Lea Hampton-O’Neil, Charles R. Bradshaw, George E. Allen, Emma L. Rawlins, Pascal Silberzan, Rafael E. Carazo Salas, Eugenia Piddini
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Cell competition is a quality control mechanism to eliminate unfit cells. Here the authors show that physical compaction of less fit cells surrounded by healthy neighbours leads to increased expression of tumour suppressor p53 in the compacted cells,
Externí odkaz:
https://doaj.org/article/917bfec21e0c49399454b3445695a286
Autor:
Josephine L. Barnes, Peng He, Masahiro Yoshida, Kaylee B. Worlock, Rik G.H. Lindeboom, Chenqu Suo, J. Patrick Pett, Anna Wilbrey-Clark, Emma Dann, Lira Mamanova, Laura Richardson, Amanda J. Oliver, Adam Pennycuick, Jessica Allen-Hyttinen, Iván T. Herczeg, Robert E. Hynds, Vitor H. Teixeira, Muzlifah Haniffa, Kyungtae Lim, Dawei Sun, Emma L. Rawlins, Krzysztof Polanski, Paul A. Lyons, John C. Marioni, Zewen Kelvin Tuong, Menna R. Clatworthy, James L. Reading, Sam M. Janes, Sarah A. Teichmann, Kerstin B. Meyer, Marko Z. Nikolić
During human development, lungs develop their roles of gas exchange and barrier function. Recent single cell studies have focused on epithelial and mesenchymal cell types, but much less is known about the developing lung immune cells, although the ai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba9e470f99f21542bfed3c556bfdae9f
https://doi.org/10.1101/2022.12.13.519713
https://doi.org/10.1101/2022.12.13.519713
Publikováno v:
Biology Open, Vol 7, Iss 4 (2018)
The airways are lined by secretory and multiciliated cells which function together to remove particles and debris from the respiratory tract. The transcriptome of multiciliated cells has been extensively studied, but the function of many of the genes
Externí odkaz:
https://doaj.org/article/d40f40b296834ce094d13b91c4d69e8b