Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Emma L Hesketh"'
Autor:
Pranav N M Shah, David J Filman, Krishanthi S Karunatilaka, Emma L Hesketh, Elisabetta Groppelli, Mike Strauss, James M Hogle
Publikováno v:
PLoS Pathogens, Vol 16, Iss 9, p e1008920 (2020)
The virions of enteroviruses such as poliovirus undergo a global conformational change after binding to the cellular receptor, characterized by a 4% expansion, and by the opening of holes at the two and quasi-three-fold symmetry axes of the capsid. T
Externí odkaz:
https://doaj.org/article/fff9a10cc1a745f58f879735bd89f47e
Autor:
Roger Castells-Graells, Jonas R. S. Ribeiro, Tatiana Domitrovic, Emma L. Hesketh, Charlotte A. Scarff, John E. Johnson, Neil A. Ranson, David M. Lawson, George P. Lomonossoff
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Castells-Graells et al. demonstrate the maturation of insect virus Nudaurelia capensis omega virus (NωV) capsids in a plant model. This shows plants are a useful tool in the study of eukaryotic viruses across Kingdoms, and they identify new features
Externí odkaz:
https://doaj.org/article/8e17ddb56f504029911eedd8efcedc8f
Autor:
Matthew J. Byrne, Matthew G. Iadanza, Marcos Arribas Perez, Daniel P. Maskell, Rachel M. George, Emma L. Hesketh, Paul A. Beales, Marc D. Zack, Colin Berry, Rebecca F. Thompson
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
The Vip3 family proteins from Bacillus thuringiensis are thought to exert their insecticidal activity through pore formation. Here authors present cryo-EM structures of a Vip3 family toxin in both inactive and activated forms and show the activated V
Externí odkaz:
https://doaj.org/article/0bb0dfee8a6a4093bdf5ddddce351782
Autor:
Emma L. Hesketh, Keith Saunders, Chloe Fisher, Joran Potze, John Stanley, George P. Lomonossoff, Neil A. Ranson
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Geminiviruses are an important plant pathogen that causes large food crop losses globally. Here the authors describe a high resolution cryo-EM structure of the Ageratum yellow vein virus and reveal the molecular details of how a single capsid protein
Externí odkaz:
https://doaj.org/article/ca7202310ade47b18e8158c00d6cfcd3
Autor:
Emma L. Hesketh, Yulia Meshcheriakova, Rebecca F. Thompson, George P. Lomonossoff, Neil A. Ranson
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Abstract Cowpea mosaic virus (CPMV) is a picorna-like plant virus. As well as an intrinsic interest in CPMV as a plant pathogen, CPMV is of major interest in biotechnology applications such as nanotechnology. Here, we report high resolution cryo elec
Externí odkaz:
https://doaj.org/article/5a08a9447f2247ffa6187b87a1890e27
Autor:
Charlotte A. Scarff, Jonas R S Ribeiro, John E. Johnson, Roger Castells-Graells, George P. Lomonossoff, Tatiana Domitrovic, David M. Lawson, Neil A. Ranson, Emma L. Hesketh
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Communications biology, vol 4, iss 1
Communications Biology
Communications biology, vol 4, iss 1
Communications Biology
Many virus capsids undergo exquisitely choreographed maturation processes in their host cells to produce infectious virions, and these remain poorly understood. As a tool for studying virus maturation, we transiently expressed the capsid protein of t
Autor:
Chunyan, Wang, Emma L, Hesketh, Tatiana M, Shamorkina, Wentao, Li, Peter J, Franken, Dubravka, Drabek, Rien, van Haperen, Sarah, Townend, Frank J M, van Kuppeveld, Frank, Grosveld, Neil A, Ranson, Joost, Snijder, Raoul J, de Groot, Daniel L, Hurdiss, Berend-Jan, Bosch
Publikováno v:
Nature communications. 13(1)
Human coronavirus OC43 is a globally circulating common cold virus sustained by recurrent reinfections. How it persists in the population and defies existing herd immunity is unknown. Here we focus on viral glycoprotein S, the target for neutralizing
Autor:
D.P. Maskell, Daniel K. Clare, Emma L. Hesketh, Andrew Howe, Martin Harrow, Joshua B. R. White, Rebecca F. Thompson, C. Alistair Siebert
Publikováno v:
Journal of Visualized Experiments
Cryo-electron microscopy (cryoEM) is a powerful technique for structure determination of macromolecular complexes, via single particle analysis (SPA). The overall process involves i) vitrifying the specimen in a thin film supported on a cryoEM grid;
Autor:
Emma L. Hesketh, Marc D. Zack, Matthew G. Iadanza, Matthew J. Byrne, D.P. Maskell, Paul A. Beales, Colin Berry, Rachel M. George, Rebecca F. Thompson, Marcos Arribas Perez
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
Insect pests are a major cause of crop losses worldwide, with an estimated economic cost of $470 billion annually. Biotechnological tools have been introduced to control such insects without the need for chemical pesticides; for instance, the develop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b21addc7deccb5127afdcaa60185db5
https://eprints.whiterose.ac.uk/174761/4/s41467-021-23146-4.pdf
https://eprints.whiterose.ac.uk/174761/4/s41467-021-23146-4.pdf
Autor:
Laurence H. Pearl, Dennis Bjorklund, Emma L. Hesketh, Rebecca F. Thompson, Hugo Muñoz-Hernández, Oscar Llorca, Gianluca Degliesposti, Mohinder Pal, J. Mark Skehel, Chrisostomos Prodromou, Lihong Zhou
The R2TP (RUVBL1-RUVBL2-RPAP3-PIH1D1) complex, in collaboration with HSP90, functions as a chaperone for the assembly and stability of protein complexes, including RNA polymerases, snRNPs and PI3 kinase-like kinases (PIKK) such as TOR and SMG1. PIKK
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4103f41fafbf7075185af61785235479
https://doi.org/10.1101/2020.11.09.374355
https://doi.org/10.1101/2020.11.09.374355