Zobrazeno 1 - 10
of 110
pro vyhledávání: '"Emma L, Lane"'
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-8 (2023)
Abstract Dopamine transmission has been implicated in motor and cognitive function. In Parkinson’s disease (PD), dopamine replacement using the precursor drug l-DOPA is the predominant treatment approach, but long-term exposure leads to the onset o
Externí odkaz:
https://doaj.org/article/cfff42f7ea5e4e1ab38d4f5ab4bbf112
Autor:
James Hennegan, Aled H. Bryant, Lauren Griffiths, Matthieu Trigano, Oliver J.M. Bartley, Joanna J. Bartlett, Carys Minahan, Willy Antoni Abreu de Oliveira, Eylan Yutuc, Sotirios Ntikas, Christos S. Bartsocas, Margarita Markouri, Eleni Antoniadou, Ioanna Laina, Owain W. Howell, Meng Li, Yuqin Wang, William J. Griffiths, Emma L. Lane, Mariah J. Lelos, Spyridon Theofilopoulos
Publikováno v:
iScience, Vol 27, Iss 1, Pp 108670- (2024)
Summary: Dysregulated cholesterol metabolism has been linked to neurodegeneration. We previously found that free, non-esterified, 7α,(25R)26-dihydroxycholesterol (7α,26-diHC), was significantly elevated in the cerebrospinal fluid of patients with P
Externí odkaz:
https://doaj.org/article/cc11eaec18cb42d988985f04f6f16725
Autor:
Emma L. Lane, Mariah J. Lelos
Publikováno v:
Disease Models & Mechanisms, Vol 15, Iss 10 (2022)
Externí odkaz:
https://doaj.org/article/ae04654ed41048849bff645e111829e8
Publikováno v:
Saudi Pharmaceutical Journal, Vol 29, Iss 2, Pp 206-212 (2021)
First line treatment for Parkinson’s disease (PD) is typically either L-dopa or a non-ergot dopamine agonist (DA). However, the options for the treatment of motor symptoms in PD patients have increased in the last thirty years, which have seen seve
Externí odkaz:
https://doaj.org/article/a12193d253044f69a87458d7213167cb
Autor:
Sophie V. Precious, Gaynor A. Smith, Andreas Heuer, Ines Jaeger, Emma L. Lane, Stephen B. Dunnett, Meng Li, Claire M. Kelly, Anne E. Rosser
Publikováno v:
Frontiers in Neuroscience, Vol 14 (2020)
Neural transplantation in neurodegenerative diseases such as Parkinson’s disease (PD) offers to replace cells lost during the progression of the disease process. Primary fetal ventral mesencephalon (VM), the origin of bona fide midbrain dopaminergi
Externí odkaz:
https://doaj.org/article/b68b33a606d4496d942f58d2fff9423c
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 22, p 12346 (2021)
Cell therapy is a promising treatment for Parkinson’s disease (PD), however clinical trials to date have shown relatively low survival and significant patient-to-patient variability. Glucagon Like Peptide-1 receptor (GLP-1R) agonists have potential
Externí odkaz:
https://doaj.org/article/7737bd875e064af7a8c6239e9244d68f
Autor:
Olivia A Lambourne, Shane Bell, Lea P Wilhelm, Erika B Yarbrough, Gabriel G Holly, Oliver M Russell, Arwa Alghamdi, Azeza M Fdel, Carmine Varricchio, Emma L Lane, Ian G Ganley, Arwyn T Jones, Matthew S Goldberg, Youcef Mehellou
The phosphorylation of ubiquitin by the mitochondrial protein kinase PINK1, upon mitochondrial depolarization, is an important step in the repair and recycling of the mitochondria via mitophagy. As mutations in PINK1 can cause early-onset Parkinson
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78095e08f1981ed3d6849627cca3ac5e
https://doi.org/10.26434/chemrxiv-2022-vcp3x
https://doi.org/10.26434/chemrxiv-2022-vcp3x
Publikováno v:
International review of neurobiology. 166
With the advent of novel advanced therapy medicinal products (ATMPs) for neurodegenerative diseases, their pathway to clinical trials and the therapeutic landscape has highlighted some new challenges, many of which are outlined in other chapters of t
Autor:
Osama F. Elabi, Rachel Pass, Irene Sormonta, Sara Nolbrant, Nicola Drummond, Agnete Kirkeby, Tilo Kunath, Malin Parmar, Emma L. Lane
Publikováno v:
Elabi, O F, Pass, R, Sormonta, I, Nolbrant, S, Drummond, N, Kirkeby, A, Kunath, T, Parmar, M & Lane, E L 2022, ' Human Embryonic Stem Cell-Derived Dopaminergic Grafts Alleviate L-DOPA Induced Dyskinesia ', Journal of Parkinson's Disease, vol. 12, no. 6, pp. 1881-1896 . https://doi.org/10.3233/JPD-212920
Elabi, O F, Pass, R, Sormonta, I, Nolbrant, S, Drummond, N, Kirkeby, A, Kunath, T, Parmar, M & Lane, E L 2022, ' Human embryonic stem cell-derived dopaminergic grafts alleviate L-DOPA induced dyskinesia ', Journal of Parkinson's disease, pp. 1-16 . https://doi.org/10.3233/JPD-212920
Elabi, O F, Pass, R, Sormonta, I, Nolbrant, S, Drummond, N, Kirkeby, A, Kunath, T, Parmar, M & Lane, E L 2022, ' Human embryonic stem cell-derived dopaminergic grafts alleviate L-DOPA induced dyskinesia ', Journal of Parkinson's disease, pp. 1-16 . https://doi.org/10.3233/JPD-212920
Background: First-in-human studies to test the efficacy and safety of human embryonic stem cells (hESC)-derived dopaminergic cells in the treatment of Parkinson’s disease (PD) are imminent. Pre-clinical studies using hESC-derived dopamine neuron tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb9137eb0b5fb285e6e02a0b53cb4ba3
Publikováno v:
Neuropsychiatric Disease and Treatment, Vol 2008, Iss Issue 5, Pp 835-845 (2008)
Emma L Lane, Olivia J Handley, Anne E Rosser, Stephen B DunnettBrain Repair Group, School of Biosciences, Cardiff University, CF10 3US, UKAbstract: Parkinson’s disease is most commonly treated with a range of pharmacotherapeutics, with the more rec
Externí odkaz:
https://doaj.org/article/a79f5795c2314fd9bdecf5715ff4e6b8