Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Emma L, Hesketh"'
Autor:
Chunyan Wang, Emma L. Hesketh, Tatiana M. Shamorkina, Wentao Li, Peter J. Franken, Dubravka Drabek, Rien van Haperen, Sarah Townend, Frank J. M. van Kuppeveld, Frank Grosveld, Neil A. Ranson, Joost Snijder, Raoul J. de Groot, Daniel L. Hurdiss, Berend-Jan Bosch
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Human coronavirus OC43 causes respiratory disease and is maintained in the human population through recurring infections. Here, by extensive structural analyses, the authors provide insights into the binding sites and breadth of neutralizing antibodi
Externí odkaz:
https://doaj.org/article/a254f75862064c1d9048eaf549552960
Autor:
Roger Castells-Graells, Jonas R. S. Ribeiro, Tatiana Domitrovic, Emma L. Hesketh, Charlotte A. Scarff, John E. Johnson, Neil A. Ranson, David M. Lawson, George P. Lomonossoff
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Castells-Graells et al. demonstrate the maturation of insect virus Nudaurelia capensis omega virus (NωV) capsids in a plant model. This shows plants are a useful tool in the study of eukaryotic viruses across Kingdoms, and they identify new features
Externí odkaz:
https://doaj.org/article/8e17ddb56f504029911eedd8efcedc8f
Autor:
Matthew J. Byrne, Matthew G. Iadanza, Marcos Arribas Perez, Daniel P. Maskell, Rachel M. George, Emma L. Hesketh, Paul A. Beales, Marc D. Zack, Colin Berry, Rebecca F. Thompson
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
The Vip3 family proteins from Bacillus thuringiensis are thought to exert their insecticidal activity through pore formation. Here authors present cryo-EM structures of a Vip3 family toxin in both inactive and activated forms and show the activated V
Externí odkaz:
https://doaj.org/article/0bb0dfee8a6a4093bdf5ddddce351782
Autor:
David P. Klebl, Matthew C. Feasey, Emma L. Hesketh, Neil A. Ranson, Heiko Wurdak, Frank Sobott, Robin S. Bon, Stephen P. Muench
Publikováno v:
iScience, Vol 24, Iss 1, Pp 102022- (2021)
Summary: Chaperonins play an important role in folding newly synthesized or translocated proteins in all organisms. The bacterial chaperonin GroEL has served as a model system for the understanding of these proteins. In comparison, its human homolog,
Externí odkaz:
https://doaj.org/article/e8e70ed735e24c10868a4546f1eca23f
Autor:
Pranav N M Shah, David J Filman, Krishanthi S Karunatilaka, Emma L Hesketh, Elisabetta Groppelli, Mike Strauss, James M Hogle
Publikováno v:
PLoS Pathogens, Vol 16, Iss 9, p e1008920 (2020)
The virions of enteroviruses such as poliovirus undergo a global conformational change after binding to the cellular receptor, characterized by a 4% expansion, and by the opening of holes at the two and quasi-three-fold symmetry axes of the capsid. T
Externí odkaz:
https://doaj.org/article/fff9a10cc1a745f58f879735bd89f47e
Autor:
Emma L. Hesketh, Keith Saunders, Chloe Fisher, Joran Potze, John Stanley, George P. Lomonossoff, Neil A. Ranson
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Geminiviruses are an important plant pathogen that causes large food crop losses globally. Here the authors describe a high resolution cryo-EM structure of the Ageratum yellow vein virus and reveal the molecular details of how a single capsid protein
Externí odkaz:
https://doaj.org/article/ca7202310ade47b18e8158c00d6cfcd3
Autor:
Emma L. Hesketh, Yulia Meshcheriakova, Rebecca F. Thompson, George P. Lomonossoff, Neil A. Ranson
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Abstract Cowpea mosaic virus (CPMV) is a picorna-like plant virus. As well as an intrinsic interest in CPMV as a plant pathogen, CPMV is of major interest in biotechnology applications such as nanotechnology. Here, we report high resolution cryo elec
Externí odkaz:
https://doaj.org/article/5a08a9447f2247ffa6187b87a1890e27
Autor:
Charlotte A. Scarff, Jonas R S Ribeiro, John E. Johnson, Roger Castells-Graells, George P. Lomonossoff, Tatiana Domitrovic, David M. Lawson, Neil A. Ranson, Emma L. Hesketh
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Communications biology, vol 4, iss 1
Communications Biology
Communications biology, vol 4, iss 1
Communications Biology
Many virus capsids undergo exquisitely choreographed maturation processes in their host cells to produce infectious virions, and these remain poorly understood. As a tool for studying virus maturation, we transiently expressed the capsid protein of t
Autor:
Chunyan, Wang, Emma L, Hesketh, Tatiana M, Shamorkina, Wentao, Li, Peter J, Franken, Dubravka, Drabek, Rien, van Haperen, Sarah, Townend, Frank J M, van Kuppeveld, Frank, Grosveld, Neil A, Ranson, Joost, Snijder, Raoul J, de Groot, Daniel L, Hurdiss, Berend-Jan, Bosch
Publikováno v:
Nature communications. 13(1)
Human coronavirus OC43 is a globally circulating common cold virus sustained by recurrent reinfections. How it persists in the population and defies existing herd immunity is unknown. Here we focus on viral glycoprotein S, the target for neutralizing
Autor:
D.P. Maskell, Daniel K. Clare, Emma L. Hesketh, Andrew Howe, Martin Harrow, Joshua B. R. White, Rebecca F. Thompson, C. Alistair Siebert
Publikováno v:
Journal of Visualized Experiments
Cryo-electron microscopy (cryoEM) is a powerful technique for structure determination of macromolecular complexes, via single particle analysis (SPA). The overall process involves i) vitrifying the specimen in a thin film supported on a cryoEM grid;