Exclusive dependence of IL-10Rα signalling on intestinal microbiota homeostasis and control of whipworm infection.

Autor: María A Duque-Correa, Natasha A Karp, Catherine McCarthy, Simon Forman, David Goulding, Geetha Sankaranarayanan, Timothy P Jenkins, Adam J Reid, Emma L Cambridge, Carmen Ballesteros Reviriego, Sanger Mouse Genetics Project, i consortium, Werner Müller, Cinzia Cantacessi, Gordon Dougan, Richard K Grencis, Matthew Berriman

Publikováno v: PLoS Pathogens, Vol 15, Iss 1, p e1007265 (2019)

The whipworm Trichuris trichiura is a soil-transmitted helminth that dwells in the epithelium of the caecum and proximal colon of their hosts causing the human disease, trichuriasis. Trichuriasis is characterized by colitis attributed to the inflamma

Externí odkaz: https://doaj.org/article/422aa5db33204c2fbceb27fee3682dbc

Mouse and cellular models of KPTN-related disorder implicate mTOR signalling in cognitive and progressive overgrowth phenotypes

Autor: Maria O. Levitin, Lettie E Rawlins, Gabriela Sanchez-Andrade, Osama A. Arshad, Stephan C. Collins, Stephen J. Sawiak, Phillip H. Iffland, Malin H.L. Andersson, Caleb Bupp, Emma L. Cambridge, Eve L. Coomber, Ian Ellis, Johanna C. Herkert, Holly Ironfield, Logan Jory, Perrine F. Kretz, Sarina G. Kant, Alexandra Neaverson, Esther Nibbeling, Christine Rowley, Emily Relton, Mark Sanderson, Ethan M. Scott, Helen Stewart, Andrew Y. Shuen, John Schreiber, Liz Tuck, James Tonks, Thorkild Terkelsen, Conny van Ravenswaaij-Arts, Pradeep Vasudevan, Olivia Wenger, Michael Wright, Andrew Day, Adam Hunter, Minal Patel, Christopher J. Lelliott, Peter B. Crino, Binnaz Yalcin, Andrew Crosby, Emma L. Baple, Darren W. Logan, Matthew E. Hurles, Sebastian S. Gerety

KPTN-related disorder (KRD) is an autosomal recessive disorder associated with germline variants in KPTN (kaptin), a component of the mTOR regulatory complex KICSTOR. To gain further insights into the pathogenesis of KRD, we analysed mouse knockout a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c4cbb0278fd0279fd1689af80476ba3a
https://doi.org/10.1101/2022.07.15.500213

Genome-wide in vivo screen identifies novel host regulators of metastatic colonization

Autor: Kim Wong, Nicola Griggs, Elizabeth Tuck, Sarah Spiegel, Emma L. Cambridge, Antonella Galli, Sanger Mouse Genetics, Hannah Wardle-Jones, Louise van der Weyden, Anneliese O. Speak, Natasha A. Karp, Andrew D. Campbell, Martin Del Castillo Velasco-Herrera, Owen J. Sansom, Thierry Voet, Thomas Tüting, Edward Ryder, Diane Gleeson, David J. Adams, Mark J. Arends, Iain C. Macaulay, Simon Clare, Tobias Bald

Publikováno v: van der Weyden, L, Arends, M J, Campbell, A D, Bald, T, Wardle-Jones, H, Griggs, N, Del Castillo Velasco-Herrera, M, Tüting, T, Sansom, O J, Karp, N A, Clare, S, Gleeson, D, Ryder, E, Galli, A, Tuck, E, Cambridge, E L, Voet, T, Macaulay, I C, Wong, K, Spiegel, S & Speak, A O & Adams, D J 2017, ' Genome-wide in vivo screen identifies novel host regulators of metastatic colonisation ', Nature, vol. 541, no. 7636, pp. 233-236 . https://doi.org/10.1038/nature20792

Metastasis is the leading cause of death for cancer patients. This multi-stage process requires tumour cells to survive in the circulation, extravasate at distant sites, then proliferate; it involves contributions from both the tumour cell and tumour

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::175cdd3f8ee9c90be56695c5a1dd4a6f
https://doi.org/10.1038/nature20792

FBXO7 sensitivity of phenotypic traits elucidated by a hypomorphic allele

Autor: Jacqueline K. White, Emma L. Cambridge, Anneliese O. Speak, Susana Caetano, Diane Gleeson, Louise van der Weyden, Katherine Harcourt, Edward Ryder, David Goulding, Leanne Kane, Brendan Doe, David J. Adams, Agnieszka Swiatkowska, Mark J. Arends, Gordon Dougan, Bushra Abu-Helil, Simon Clare, Carmen Ballesteros Reviriego

Publikováno v: PLoS ONE, Vol 14, Iss 3, p e0212481 (2019)
PLoS ONE
Ballesteros Reviriego, C, Clare, S, Arends, M, Cambridge, E L, Swiatkowska, A, Caetano, S, Abu-Helil, B, Kane, L, Harcourt, K, Goulding, D, Gleeson, D, Ryder, E, Doe, B, White, J K, van der Weyden, L, Dougan, G, Adams, D J & Speak, A O 2019, ' FBXO7 sensitivity of phenotypic traits elucidated by a hypomorphic allele ', PLoS ONE, vol. 14, no. 3 . https://doi.org/10.1371/journal.pone.0212481

FBXO7 encodes an F box containing protein that interacts with multiple partners to facilitate numerous cellular processes and has a canonical role as part of an SCF E3 ubiquitin ligase complex. Mutation of FBXO7 is responsible for an early onset Park

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc680df5e362c0b09b46f701cb4b40a0
https://www.repository.cam.ac.uk/handle/1810/290682

The antiviral restriction factor IFN-induced transmembrane protein 3 prevents cytokine-driven CMV pathogenesis

Autor: Maria A, Stacey, Simon, Clare, Mathew, Clement, Morgan, Marsden, Juneid, Abdul-Karim, Leanne, Kane, Katherine, Harcourt, Cordelia, Brandt, Ceri A, Fielding, Sarah E, Smith, Rachael S, Wash, Silvia Gimeno, Brias, Gabrielle, Stack, George, Notley, Emma L, Cambridge, Christopher, Isherwood, Anneliese O, Speak, Zoë, Johnson, Walter, Ferlin, Simon A, Jones, Paul, Kellam, Ian R, Humphreys

Publikováno v: The Journal of Clinical Investigation

The antiviral restriction factor IFN-induced transmembrane protein 3 (IFITM3) inhibits cell entry of a number of viruses, and genetic diversity within IFITM3 determines susceptibility to viral disease in humans. Here, we used the murine CMV (MCMV) mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::5b5d0f260eb058d4a4aee340511cab30
http://hdl.handle.net/10044/1/69587