Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Emma K. Jennings"'
Publikováno v:
STAR Protocols, Vol 2, Iss 1, Pp 100284- (2021)
Summary: This protocol uses Nr4a1-GFP Nr4a3-Tocky mice to study T cell receptor (TCR) signaling using flow cytometry. It identifies the optimal mouse transgenic status and fluorochromes compatible with the dual reporter. This protocol has application
Externí odkaz:
https://doaj.org/article/522f6c739abd4cc2b2353f7b18c64a89
Autor:
Thomas A E Elliot, Emma K Jennings, David A J Lecky, Sophie Rouvray, Gillian M Mackie, Lisa Scarfe, Lozan Sheriff, Masahiro Ono, Kendle M Maslowski, David Bending
Publikováno v:
Discovery Immunology. 1
In lymphocytes, Nr4a gene expression is specifically regulated by antigen receptor signalling, making them ideal targets for use as distal T cell receptor (TCR) reporters. Nr4a3-Timer of cell kinetics and activity (Tocky) mice are a ground-breaking t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::99d64b4f4f24e4fccb344db5d1a1081c
https://doi.org/10.1093/discim/kyac009
https://doi.org/10.1093/discim/kyac009
Autor:
Adriana Flores-Langarica, Kendle M. Maslowski, Natasha Thawait, Thomas A.E. Elliot, Alastair Copland, David Bending, Emma K. Jennings, David A.J. Lecky, David C. Wraith
Publikováno v:
Immunity
Summary How T cell receptor (TCR) signal strength modulates T cell function and to what extent this is modified by immune checkpoint blockade (ICB) are key questions in immunology. Using Nr4a3-Tocky mice, we characterized early quantitative and quali
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f43037d602993e7db87f2fde608beb0a
https://pubmed.ncbi.nlm.nih.gov/34534438
https://pubmed.ncbi.nlm.nih.gov/34534438
Autor:
Natasha Thawait, Emma K. Jennings, Adriana Flores-Langarica, David Bending, David A.J. Lecky, Thomas A.E. Elliot, David C. Wraith
SummaryHow T cell receptor (TCR) signal strength modulates T cell function and to what extent this is modified by immune checkpoint blockade (ICB) are key questions in immunology. Using Nr4a3-Tocky mice as a digital read-out of NFAT pathway activity,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::447dd01e9dfc4af98625d416b3530239
https://doi.org/10.1101/2021.03.02.431957
https://doi.org/10.1101/2021.03.02.431957
Publikováno v:
STAR Protocols
Summary This protocol uses Nr4a1-GFP Nr4a3-Tocky mice to study T cell receptor (TCR) signaling using flow cytometry. It identifies the optimal mouse transgenic status and fluorochromes compatible with the dual reporter. This protocol has applications
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::027ace955554e56f4377f8115408f687
https://pubmed.ncbi.nlm.nih.gov/33532733
https://pubmed.ncbi.nlm.nih.gov/33532733
Autor:
David Bending, Emma K. Jennings, Natasha Thawait, Juan Carlos Yam-Puc, David C. Wraith, Shivani Kanabar, Kai-Michael Toellner, Graham Anderson, Thomas A.E. Elliot, Masahiro Ono
Publikováno v:
Cell Reports, Vol 33, Iss 5, Pp 108328-(2020)
Cell Reports
Cell Reports
Summary Nr4a receptors are activated by T cell receptor (TCR) signaling and play key roles in T cell differentiation. Which TCR signaling pathways regulate Nr4a receptors and their sensitivities to TCR signal strength and duration remains unclear. Us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6054e34df07cc18ff9a2001676a6283
http://www.sciencedirect.com/science/article/pii/S2211124720313176
http://www.sciencedirect.com/science/article/pii/S2211124720313176
Autor:
Emma K. Jennings, David Bending, Juan Carlos Yam-Puc, Graham Anderson, Shivani Kanabar, Masahiro Ono, Thomas A.E. Elliot, Kai-Michael Toellner, David C. Wraith, Natasha Thawait
SummaryNr4a receptors are activated by T cell receptor (TCR) and B cell receptor (BCR) signalling and play key roles in T cell differentiation and promoting T cell exhaustion. How TCR signalling pathways regulate Nr4a receptors and their sensitivitie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5aa44cfb1e93423c1022f066efdca40
Publikováno v:
STAR Protocols, Vol 2, Iss 1, Pp 100284-(2021)
Summary This protocol uses Nr4a1-GFP Nr4a3-Tocky mice to study T cell receptor (TCR) signaling using flow cytometry. It identifies the optimal mouse transgenic status and fluorochromes compatible with the dual reporter. This protocol has applications
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::debfe09ebc45bb835f7a6de728dc0f48
https://doi.org/10.1016/j.xpro.2020.100284
https://doi.org/10.1016/j.xpro.2020.100284