Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Emma K. Dodds"'
Autor:
Sara E. Douglas, Emma K. Dodds, Tanya Coleman, David R. Thomas, Robert J. Ife, Malcolm Meeson, Graham J. Riley, Andrew P. Lightfoot, Lorraine Campbell, Andrew D. Gribble, David G. Cooper, Ian Thomson Forbes
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:1055-1058
Novel 5-HT7 receptor antagonists containing the benzocycloheptanone core were identified from high throughput screening. Molecular modelling and SAR studies have converted these intractable hits into a more potent, selective and tractable series, exe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53f0e00e227bc9ca5cdf57ed410801df
https://doi.org/10.1016/s0960-894x(03)00077-5
https://doi.org/10.1016/s0960-894x(03)00077-5
Autor:
Emma K. Dodds, Jayneeta Gohil, Robert John Ife, Ian Thomson Forbes, Pieter H. E. Groot, Kitty Moores, Theo A. Berkhout, Deirdre M. B. Hickey, David Gwyn Cooper, Martin Stockley, Malcolm L. Meeson
Publikováno v:
Bioorganicmedicinal chemistry letters. 10(16)
A weak HTS hit at the CCR2B receptor has been converted into a potent antagonist by array SAR studies. Selectivity over the closely related CCR5 receptor is also achieved.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::989de0004444e8338e8626d3a06ea554
https://pubmed.ncbi.nlm.nih.gov/10969972
https://pubmed.ncbi.nlm.nih.gov/10969972