Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Emma K. Biggs"'
Autor:
Pierre Larraufie, Geoffrey P. Roberts, Anne K. McGavigan, Richard G. Kay, Joyce Li, Andrew Leiter, Audrey Melvin, Emma K. Biggs, Peter Ravn, Kathleen Davy, David C. Hornigold, Giles S.H. Yeo, Richard H. Hardwick, Frank Reimann, Fiona M. Gribble
Publikováno v:
Cell Reports, Vol 26, Iss 6, Pp 1399-1408.e6 (2019)
Summary: Bariatric surgery is widely used to treat obesity and improves type 2 diabetes beyond expectations from the degree of weight loss. Elevated post-prandial concentrations of glucagon-like peptide 1 (GLP-1), peptide YY (PYY), and insulin are wi
Externí odkaz:
https://doaj.org/article/979cdd19068a475e993981d0880f746c
Autor:
Kay-Tee Khaw, Angela M. Wood, Julian L. Griffin, Gabi Kastenmüller, Fiona M. Gribble, Adam S. Butterworth, Luca A. Lotta, Verena Zuber, Chen Li, Victoria P W Auyeung, Johannes Raffler, Isobel D. Stewart, Nita G. Forouhi, Jian'an Luan, Nicholas J. Wareham, Claudia Langenberg, Maik Pietzner, Laura B. L. Wittemans, Eleanor Wheeler, Robert A. Scott, Roberto Bonelli, John Danesh, Frank Reimann, Praveen Surendran, Stephen Burgess, Ellie Paige, Clare Oliver-Williams, Albert Koulman, Fumiaki Imamura, Eric B. Fauman, Gregory A. Michelotti, Melanie Bahlo, Eleanor Sanderson, Emma K. Biggs
Publikováno v:
Nat. Genet. 53, 54-64 (2021)
In cross-platform analyses of 174 metabolites, we identify 499 associations (P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d01457abaa2186c603f1aef63b70d908
https://doi.org/10.1038/s41588-020-00751-5
https://doi.org/10.1038/s41588-020-00751-5
Autor:
Claire L Meek, Richard G. Kay, Sam G Galvin, Pierre Larraufie, Rachel E. Foreman, Frank Reimann, Fiona M. Gribble, Peter Ravn, Emma K. Biggs, Lutz Jermutus
Publikováno v:
Journal of Proteome Research
Journal of Proteome Research, American Chemical Society, 2021, 20 (9), pp.4507-4517. ⟨10.1021/acs.jproteome.1c00463⟩
Journal of Proteome Research, American Chemical Society, 2021, 20 (9), pp.4507-4517. ⟨10.1021/acs.jproteome.1c00463⟩
To characterize the impact of metabolic disease on the peptidome of human and mouse pancreatic islets, LC-MS was used to analyze extracts of human and mouse islets, purified mouse alpha, beta, and delta cells, supernatants from mouse islet incubation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36cdc3a6748039ac87cfa60ab5a951b4
https://hal-agroparistech.archives-ouvertes.fr/hal-03449922
https://hal-agroparistech.archives-ouvertes.fr/hal-03449922
Autor:
Kathleen Davy, Andrew B. Leiter, Audrey Melvin, Anne K. McGavigan, Joyce Li, Richard H. Hardwick, Geoffrey P. Roberts, Emma K. Biggs, Richard G. Kay, Giles S.H. Yeo, Peter Ravn, Fiona M. Gribble, David C. Hornigold, Pierre Larraufie, Frank Reimann
Publikováno v:
Cell Reports, Vol 26, Iss 6, Pp 1399-1408.e6 (2019)
Cell Reports
Cell Reports, Elsevier Inc, 2019, 26 (6), pp.1399-1408.e6. ⟨10.1016/j.celrep.2019.01.047⟩
Cell Reports
Cell Reports, Elsevier Inc, 2019, 26 (6), pp.1399-1408.e6. ⟨10.1016/j.celrep.2019.01.047⟩
Summary Bariatric surgery is widely used to treat obesity and improves type 2 diabetes beyond expectations from the degree of weight loss. Elevated post-prandial concentrations of glucagon-like peptide 1 (GLP-1), peptide YY (PYY), and insulin are wid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae54233a151a0b071cd3248fbe10f856
http://www.sciencedirect.com/science/article/pii/S2211124719300658
http://www.sciencedirect.com/science/article/pii/S2211124719300658
Autor:
Fumiaki Imamura, Maik Pietzner, Fiona M. Gribble, Robert A. Scott, John Danesh, Clare Oliver-Williams, Julian L. Griffin, Roberto Bonelli, Frank Reimann, Isobel D. Stewart, Stephen Burgess, Kay-Tee Khaw, Luca A. Lotta, Adam S. Butterworth, Eric B. Fauman, Melanie Bahlo, Angela M. Wood, Nita G. Forouhi, Emma K. Biggs, Gabi Kastenm uumlller, Johannes Raffler, Praveen Surendran, Chen Li, Victoria P W Auyeung, Verena Zuber, Nicholas J. Wareham, Eleanor Sanderson, Gregory A. Michelotti, Laura B. L. Wittemans, Claudia Langenberg, Albert Koulman
Circulating levels of small molecules or metabolites are highly heritable, but the impact of genetic differences in metabolism on human health is not well understood. In this cross-platform, genome-wide meta-analysis of 174 metabolite levels across s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6356d26b2c4f09f4f877739e65169de3
Autor:
David Baker, Frank Reimann, Peter Ravn, Fiona M. Gribble, Lihuan Liang, Emma K. Biggs, Jacqueline Naylor, Rachel Collier, Matthew P. Coghlan, Shimona Madalli, David C. Hornigold
AIMS/HYPOTHESIS: Glucagon like peptide-1 (GLP-1) enhances glucose-dependent insulin secretion by binding to GLP-1 receptors (GLP1Rs) on pancreatic beta cells. GLP-1 mimetics are used in the clinic for the treatment of type 2 diabetes, but despite the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b56082ea188f4d6516a604151d12790d
https://www.repository.cam.ac.uk/handle/1810/276374
https://www.repository.cam.ac.uk/handle/1810/276374
Autor:
Davide Chiarugi, Tanmay Sukthankar, Clemence Blouet, Frank Reimann, Fiona M. Gribble, Brain Y Lam, Ilona Zvetkova, Joseph Polex-Wolf, Giles Sh Yeo, Tamana Darwish, John Tadross, Emma K Biggs, Warren Pan, Alice E. Adriaenssens, Milind Girish
Publikováno v:
Cell Metabolism
Summary Ambiguity regarding the role of glucose-dependent insulinotropic polypeptide (GIP) in obesity arises from conflicting reports asserting that both GIP receptor (GIPR) agonism and antagonism are effective strategies for inhibiting weight gain.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d78d8c3386be3a64d2c650697c7699d4
http://europepmc.org/articles/PMC6838660
http://europepmc.org/articles/PMC6838660
Publikováno v:
The Biochemical journal. 474(1)
Treatments for diabetes and obesity based on enteroendocrine hormones are a focus of research interest, partly due to the successes of glucagon-like peptide-1 (GLP-1) mimetic peptides in the treatment of diabetes and the correlation of altered entero
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3b287ce686b1da10889ce8b0edc7262
https://pubmed.ncbi.nlm.nih.gov/27422784
https://pubmed.ncbi.nlm.nih.gov/27422784