Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Emma K Murray"'
Autor:
Alyssa A. Lombardi, Andrew A. Gibb, Ehtesham Arif, Devin W. Kolmetzky, Dhanendra Tomar, Timothy S. Luongo, Pooja Jadiya, Emma K. Murray, Pawel K. Lorkiewicz, György Hajnóczky, Elizabeth Murphy, Zoltan P. Arany, Daniel P. Kelly, Kenneth B. Margulies, Bradford G. Hill, John W. Elrod
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Myofibroblast differentiation contributes to extracellular matrix remodeling and fibrosis. Here, the authors report that alterations in mitochondrial calcium uptake is essential for metabolic reprogramming and epigenetic signaling for activation of t
Externí odkaz:
https://doaj.org/article/bdc7ccfd4f494ac28c7dce1cb6b33f83
Autor:
Joanne F. Garbincius, Timothy S. Luongo, Jonathan P. Lambert, Adam S. Mangold, Emma K. Murray, Alycia N. Hildebrand, Pooja Jadiya, John W. Elrod
Publikováno v:
bioRxiv
BackgroundMitochondrial calcium (mCa2+) uptake through the mitochondrial calcium uniporter channel (mtCU) stimulates metabolism to meet acute increases in cardiac energy demand. However, excessivemCa2+uptake during stress, as in ischemia-reperfusion,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5922de7c4c56848936d3308c62c1b185
https://doi.org/10.1101/2023.04.17.537222
https://doi.org/10.1101/2023.04.17.537222
Autor:
Alaina L. Headrick, Jaslyn Johnson, Timothy A. McKinsey, Giana Schena, Yijun Yang, Sadia Mohsin, Deborah M Eaton, Raj Kishore, Keith A. Koch, John W. Elrod, Steven R. Houser, Hajime Kubo, Remus M. Berretta, Alycia N Hildebrand, Emma K Murray
Publikováno v:
Am J Physiol Heart Circ Physiol
Heart failure is the one of the leading causes of death in the United States. Heart failure is a complex syndrome caused by numerous diseases, including severe myocardial infarction (MI). MI occurs after an occlusion of a cardiac artery causing downs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::876566a6f6474635de6efedc48a6a574
https://doi.org/10.1152/ajpheart.00197.2021
https://doi.org/10.1152/ajpheart.00197.2021
Autor:
John W. Elrod, Steven R. Houser, Markus Wallner, Remus M. Berretta, Dhanendra Tomar, Anh T Huynh, Joanne F Garbincius, Deborah M Eaton, Emma K Murray, Devin W. Kolmetzky, Andrew A. Gibb
Publikováno v:
JACC: Basic to Translational Science
Visual Abstract
Highlights • Early cardiac mitochondrial dysfunction is mediated by transcriptional down-regulation of the mitochondrial proteome. • Comprehensive metabolic remodeling is conserved throughout HFpEF progression and includes in
Highlights • Early cardiac mitochondrial dysfunction is mediated by transcriptional down-regulation of the mitochondrial proteome. • Comprehensive metabolic remodeling is conserved throughout HFpEF progression and includes in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::474acd63270db1077349e2d878112f6b
https://doi.org/10.1016/j.jacbts.2021.07.004
https://doi.org/10.1016/j.jacbts.2021.07.004
Autor:
Pooja Jadiya, Jonathan P. Lambert, Emma K Murray, Joanne F Garbincius, Adam S Mangold, Timothy S. Luongo, Alycia N Hildebrand, John W. Elrod
Publikováno v:
Circulation. 142
Calcium (Ca 2+ ) uptake into the mitochondrial matrix occurs via the mitochondrial Ca 2+ uniporter channel (mtCU) and tunes mitochondrial metabolism to meet acute changes in cellular ATP demand. However, the role of mtCU-dependent mitochondrial Ca 2+
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ce5baa627628cb5e92ee464c4e1d3fdb
https://doi.org/10.1161/circ.142.suppl_3.16592
https://doi.org/10.1161/circ.142.suppl_3.16592
Autor:
John W. Elrod, Devin W. Kolmetzky, Andrew A. Gibb, Zolt Arany, Pawel Lorkiewicz, Michael P Lazaropoulos, Anh T Huynh, Kenneth B. Margulies, Alyssa A. Lombardi, Bradford G. Hill, Emma K Murray, Daniel P. Kelly
Publikováno v:
Circulation. 142
Cardiac fibrosis is mediated by the activation and differentiation of resident cardiac fibroblasts. While initially reparative, chronic activation leads to progressive cardiac dysfunction. Associated with myofibroblast formation are changes in metabo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::daa256b9c55b4df335724bbbd53b8cd3
https://doi.org/10.1161/circ.142.suppl_3.16406
https://doi.org/10.1161/circ.142.suppl_3.16406
Autor:
Dhanendra Tomar, Anh T Huynh, Deborah M Eaton, Andrew A. Gibb, Remus M. Berretta, Joanne F Garbincius, Devin W. Kolmetzky, Emma K Murray, Steve R. Houser, John W. Elrod, M. Wallner
Publikováno v:
Circulation. 142
Heart failure with preserved ejection fraction (HFpEF) accounts for ~50% of HF cases, with no effective treatments. We previously reported that a feline aortic banding model recapitulates many of the multi-factorial features of HFpEF, including: LV h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::26df4731a44d489f17f23ccd29919b40
https://doi.org/10.1161/circ.142.suppl_3.16434
https://doi.org/10.1161/circ.142.suppl_3.16434
Autor:
Joanne F Garbincius, Alycia N Hildebrand, Jonathan P. Lambert, Timothy S. Luongo, Adam S Mangold, John W. Elrod, Emma K Murray, Pooja Jadiya
Publikováno v:
Circulation Research. 127
The mitochondrial calcium uniporter (MCU) forms the pore of the mitochondrial calcium uniporter channel (mtCU) and is required for rapid mitochondrial Ca 2+ ( m Ca 2+ ) uptake. MCU is necessary to increase cardiac energetics to fuel an increase in ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c19bacc5d838fecab7071155084e1899
https://doi.org/10.1161/res.127.suppl_1.506
https://doi.org/10.1161/res.127.suppl_1.506
Publikováno v:
Circulation Research. 125
Necrotic cell death is the main way in which cells die during myocardial infarction (MI) and heart failure (HF), yet the molecular mechanisms regulating necrotic cell death are poorly defined. To elucidate the key regulators of plasma membrane ruptur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a74ea0b7a657d9eedefa229bd47af3d
https://doi.org/10.1161/res.125.suppl_1.737
https://doi.org/10.1161/res.125.suppl_1.737
Autor:
Devin W. Kolmetzky, Bradford G. Hill, Kenneth B. Margulies, Emma K Murray, Andrew A. Gibb, Daniel P. Kelly, Anh T Huynh, Zolt Arany, Alyssa A. Lombardi, Pawel Lorkiewicz, John W. Elrod, Yinfei Tan
Publikováno v:
Circulation Research. 125
Cardiac fibrosis occurs in ischemic heart failure, genetic cardiomyopathies, diabetes, and aging. While initially considered reparative, resident cardiac fibroblasts (CFs) activation/differentiation to myofibroblasts provide contractile and integral
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4cffea5aaed324c12b62f74994bb6af1
https://doi.org/10.1161/res.125.suppl_1.517
https://doi.org/10.1161/res.125.suppl_1.517