Výsledky vyhledávání - "Emma J. Walsh"

Accelerated developmental adipogenesis programs adipose tissue dysfunction and cardiometabolic risk in offspring born to dams with metabolic dysfunction

Autor: Sebastian Larion, Radha Dutt Singh, Emma J. Walsh, Anna Mikolajczak, Jennifer A Thompson, Carol Huang, Taylor B Scheidl, Nada A Sallam

Publikováno v: American journal of physiology. Endocrinology and metabolism. 321(5)

This study determined if a perturbation in in utero adipogenesis leading to later life adipose tissue (AT) dysfunction underlies programming of cardiometabolic risk in offspring born to dams with metabolic dysfunction. Female mice heterozygous for th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70432bee6124f4d70394711b754e32be
https://pubmed.ncbi.nlm.nih.gov/34459218

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Abnormal myosin phosphatase targeting subunit 1 phosphorylation and actin polymerization contribute to impaired myogenic regulation of cerebral arterial diameter in the type 2 diabetic Goto-Kakizaki rat

Autor: Hai-Lei Zhu, Christine Campbell, Olaia Colinas, Khaled S. Abd-Elrahman, Michael P. Walsh, Emma J. Walsh, William C. Cole

Publikováno v: Journal of Cerebral Blood Flow & Metabolism. 37:227-240

The myogenic response of cerebral resistance arterial smooth muscle to intraluminal pressure elevation is a key physiological mechanism regulating blood flow to the brain. Rho-associated kinase plays a critical role in the myogenic response by activa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d455291736e47ce04841a2f0e0d78200
https://doi.org/10.1177/0271678x15622463

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Cytoskeletal Reorganization Evoked by Rho-associated kinase- and Protein Kinase C-catalyzed Phosphorylation of Cofilin and Heat Shock Protein 27, Respectively, Contributes to Myogenic Constriction of Rat Cerebral Arteries

Autor: Gary J. Kargacin, Emma J. Walsh, William C. Cole, Dylan M. Cole, X. Zoë Zhong, Olaia Colinas, Alejandro Moreno-Domínguez, Hai-Lei Zhu, Ahmed F. El-Yazbi, Michael P. Walsh

Publikováno v: Journal of Biological Chemistry. 289:20939-20952

Our understanding of the molecular events contributing to myogenic control of diameter in cerebral resistance arteries in response to changes in intravascular pressure, a fundamental mechanism regulating blood flow to the brain, is incomplete. Myosin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a82d55be3b6ecdc398db344fda7e2db4
https://doi.org/10.1074/jbc.m114.553743

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Ca2+sensitization due to myosin light chain phosphatase inhibition and cytoskeletal reorganization in the myogenic response of skeletal muscle resistance arteries

Autor: Michael A. Hill, William C. Cole, Alejandro Moreno-Domínguez, Michael P. Walsh, Ahmed F. El-Yazbi, Olaia Colinas, Emma J. Walsh

Publikováno v: The Journal of Physiology. 591:1235-1250

Key points • Blood flow to our organs is maintained within a defined range to provide an adequate supply of nutrients and remove waste products by contraction and relaxation of smooth muscle cells of resistance arteries and arterioles. • The abil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e323e7bcd4992428b94ea42b19f6bdda
https://doi.org/10.1113/jphysiol.2012.243576

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Stromatoxin-sensitive, heteromultimeric Kv2.1/Kv9.3 channels contribute to myogenic control of cerebral arterial diameter

Autor: William C. Cole, Emma J. Walsh, Ahmed F. El-Yazbi, Chiu-Hsiang Liao, Khaled S. Abd-Elrahman, Xi Zoë Zhong, Michael P. Walsh

Publikováno v: The Journal of Physiology. 588:4519-4537

Cerebral vascular smooth muscle contractility plays a crucial role in controlling arterial diameter and, thereby, blood flow regulation in the brain. A number of K+ channels have been suggested to contribute to the regulation of diameter by controlli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eb0df048a802c223f081be1fe26f7612
https://doi.org/10.1113/jphysiol.2010.196618

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Pressure-dependent contribution of Rho kinase-mediated calcium sensitization in serotonin-evoked vasoconstriction of rat cerebral arteries

Autor: Michael P. Walsh, Emma J. Walsh, Rosalyn P. Johnson, William C. Cole, Ahmed F. El-Yazbi, Kosuke Takeya

Publikováno v: The Journal of Physiology. 588:1747-1762

Our understanding of the cellular signalling mechanisms contributing to agonist-induced constriction is almost exclusively based on the study of conduit arteries. Resistance arteries/arterioles have received less attention as standard biochemical app

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a6c8fff5bf54b1e84126399146b11c6c
https://doi.org/10.1113/jphysiol.2010.187146

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Ca2+sensitization via phosphorylation of myosin phosphatase targeting subunit at threonine-855 by Rho kinase contributes to the arterial myogenic response

Autor: Kosuke Takeya, Ahmed F. El-Yazbi, William C. Cole, Rosalyn P. Johnson, Emma J. Walsh, Michael P. Walsh

Publikováno v: The Journal of Physiology. 587:2537-2553

Ca2+ sensitization has been postulated to contribute to the myogenic contraction of resistance arteries evoked by elevation of transmural pressure. However, the biochemical evidence of pressure-induced increases in phosphorylated myosin light chain p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6e6f6a02131297310668ccfbfc91811e
https://doi.org/10.1113/jphysiol.2008.168252

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