Zobrazeno 1 - 10 of 19 pro vyhledávání: '"Emma J. Sawyer"'
1
Akademický článek
Fine-mapping the HOXB region detects common variants tagging a rare coding allele: evidence for synthetic association in prostate cancer.
Autor: Edward J Saunders, Tokhir Dadaev, Daniel A Leongamornlert, Sarah Jugurnauth-Little, Malgorzata Tymrakiewicz, Fredrik Wiklund, Ali Amin Al Olama, Sara Benlloch, David E Neal, Freddie C Hamdy, Jenny L Donovan, Graham G Giles, Gianluca Severi, Henrik Gronberg, Markus Aly, Christopher A Haiman, Fredrick Schumacher, Brian E Henderson, Sara Lindstrom, Peter Kraft, David J Hunter, Susan Gapstur, Stephen Chanock, Sonja I Berndt, Demetrius Albanes, Gerald Andriole, Johanna Schleutker, Maren Weischer, Børge G Nordestgaard, Federico Canzian, Daniele Campa, Elio Riboli, Tim J Key, Ruth C Travis, Sue A Ingles, Esther M John, Richard B Hayes, Paul Pharoah, Kay-Tee Khaw, Janet L Stanford, Elaine A Ostrander, Lisa B Signorello, Stephen N Thibodeau, Daniel Schaid, Christiane Maier, Adam S Kibel, Cezary Cybulski, Lisa Cannon-Albright, Hermann Brenner, Jong Y Park, Radka Kaneva, Jyotsna Batra, Judith A Clements, Manuel R Teixeira, Jianfeng Xu, Christos Mikropoulos, Chee Goh, Koveela Govindasami, Michelle Guy, Rosemary A Wilkinson, Emma J Sawyer, Angela Morgan, COGS-CRUK GWAS-ELLIPSE (Part of GAME-ON) Initiative, UK Genetic Prostate Cancer Study Collaborators, UK ProtecT Study Collaborators, PRACTICAL Consortium, Douglas F Easton, Ken Muir, Rosalind A Eeles, Zsofia Kote-Jarai
Publikováno v: PLoS Genetics, Vol 10, Iss 2, p e1004129 (2014)
The HOXB13 gene has been implicated in prostate cancer (PrCa) susceptibility. We performed a high resolution fine-mapping analysis to comprehensively evaluate the association between common genetic variation across the HOXB genetic locus at 17q21 and
Externí odkaz: https://doaj.org/article/ef4e48a676e14b05b1bb979807ceb684
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2
Germline BRCA Mutations Are Associated With Higher Risk of Nodal Involvement, Distant Metastasis, and Poor Survival Outcomes in Prostate Cancer
Autor: Jackie Cook, Louise Izatt, Rosalind A. Eeles, Lucy Side, Carole Brewer, Huw Dorkins, Trevor Cole, Rosemarie Davidson, Mary Porteous, D. Gareth Evans, Jacqueline Eason, Antonis C. Antoniou, Daniel Leongamornlert, Alan Donaldson, Audrey Ardern-Jones, Chee Goh, N. Mahmud, Marc Tischkowitz, Steve Ellis, David Olmos, Rosemary A. Wilkinson, Michelle Guy, Malgorzata Tymrakiewicz, Fiona Douglas, Ed Saunders, Emma J. Sawyer, Susan Peock, Douglas F. Easton, Koveela Govindasami, Elena Castro, Tokhir Dadaev, Diana Eccles, Shirley Hodgson, M. John Kennedy, Alex Murray, Zsofia Kote-Jarai, Debra Frost
Publikováno v: Castro, E, Goh, C, Olmos, D, Saunders, E, Leongamornlert, D, Tymrakiewicz, M, Mahmud, N, Dadaev, T, Govindasami, K, Guy, M, Sawyer, E, Wilkinson, R, Ardern-Jones, A, Ellis, S, Frost, D, Peock, S, Evans, D G, Tischkowitz, M, Cole, T, Davidson, R, Eccles, D, Brewer, C, Douglas, F, Porteous, M E, Donaldson, A, Dorkins, H, Izatt, L, Cook, J, Hodgson, S, Kennedy, M J, Side, L E, Eason, J, Murray, A, Antoniou, A C, Easton, D F, Kote-Jarai, Z & Eeles, R 2013, ' Re : Germline brca mutations are associated with higher risk of nodal involvement, distant metastasis, and poor survival outcomes in prostate cancer ', Journal of Urology, vol. 190, no. 6 . https://doi.org/10.1016/j.juro.2013.08.101
for this article http://dx.doi.org/10.1016/j.juro.2013.08.101 available at http://jurology.com/ Editorial Comment: As we begin to better understand the influence of specific genetic mutations on prostate carcinogenesis, it is critically important to
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fb550cd1f227248693b7a9a9542faa2
https://doi.org/10.1200/jco.2012.43.1882
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4
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array
Autor: Artitaya Lophatananon, W. Ryan Diver, Stig E. Bojesen, Roman Corral, Fredrick R. Schumacher, Stephen J. Chanock, Shannon K. McDonnell, Graham G. Giles, Craig C. Teerlink, Douglas F. Easton, Cezary Cybulski, Brian E. Henderson, Judith A. Clements, Ali Amin Al Olama, Francois Bacot, David P. Dearnaley, Elio Riboli, Peter Klarskov, Daniel Vincent, Rosemary A. Wilkinson, Danielle M. Karyadi, Michelle Guy, Vincent Khoo, Christopher A. Haiman, Afshan Siddiq, M. Andreas Røder, Amit Joshi, Jong Y. Park, Walther Vogel, Henrik Grönberg, Angela Cox, Rudolf Kaaks, Nora Pashayan, Timothy J. Key, C. R. J. Woodhouse, Jarmo Virtamo, Meredith Yeager, Malgorzata Tymrakiewicz, Sune F. Nielsen, Richard B. Hayes, Johanna Schleutker, Gianluca Severi, Robert Huddart, Wei Zheng, Thomas A. Sellers, Melanie Maranian, Shahana Ahmed, David E. Neal, Daniel Leongamornlert, Zsofia Kote-Jarai, Tiina Wahlfors, Loic Le Marchand, Kay-Tee Khaw, Tokhir Dadaev, Lisa A. Cannon-Albright, Janet L. Stanford, William J. Blot, Andy C. H. Lee, Freddie C. Hamdy, Siqun L. Zheng, Rosalind A. Eeles, Alison M. Dunning, Mariana C. Stern, Melissa C. Southey, Don M. Conroy, Kenneth Muir, Ahva Shahabi, Alan Horwich, Gerald L. Andriole, Antje E. Rinckleb, Srilakshmi Srinivasan, Tim Dudderidge, Joe Dennis, Radka Kaneva, Vanio Mitev, Angela Morgan, Sue A. Ingles, Adam S. Kibel, Markus Aly, Koveela Govindasami, Maya Ghoussaini, Jenny L Donovan, Manuel R. Teixeira, Emma J. Sawyer, Sara Lindström, Jiangfeng Xu, Maren Weischer, Ed Dicks, Jyotsna Batra, S Jugurnauth-Little, Hui-Yi Lin, Suzanne Kolb, Lisa B. Signorello, Dallas R. English, Antonis C. Antoniou, Federico Canzian, Anssi Auvinen, Mia M. Gaudet, Paula Paulo, Paul D.P. Pharoah, Heiko Müller, Qiuyin Cai, Børge G. Nordestgaard, Esther M. John, Sonja I. Berndt, D J Schaid, Daniele Campa, Chris Ogden, Colin Cooper, Craig Luccarini, Jan Lubinski, Elaine A. Ostrander, Ruth C. Travis, Dominika Wokołorczyk, John L. Hopper, Sofia Maia, Sara Benlloch, Chris Parker, Erika M. Kwon, Nicholas van As, Caroline Baynes, C. Slavov, Teuvo L.J. Tammela, Ethan M. Lange, Daniel C. Tessier, David J. Hunter, Dietrich Rothenbacher, Robert A. Stephenson, Liesel M. FitzGerald, Christiane Maier, Hermann Brenner, Kathleen A. Cooney, Graham A. Colditz, Felicity Lose, Edward J. Saunders, Demetrius Albanes, Stephen N. Thibodeau, Fredrik Wiklund, Amanda B. Spurdle, Jan Adolfsson, Susan M. Gapstur, Peter Kraft, Bettina F. Drake, Alan Thompson
Publikováno v: Nature Genetics
Nature Genetics; Vol 45
Prostate cancer is the most frequently diagnosed cancer in males in developed countries. To identify common prostate cancer susceptibility alleles, we genotyped 211,155 SNPs on a custom Illumina array (iCOGS) in blood DNA from 25,074 prostate cancer
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dc5d5f82460009b403d064c3a16e687
https://doi.org/10.1038/ng.2560
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5
Germline BRCA1 mutations increase prostate cancer risk
Autor: Amanda L. Hall, Doug Easton, Emma J. Sawyer, Koveela Govindasami, Rosemary A. Wilkinson, Michelle Guy, Elena Castro, Ed Saunders, Rosalind A. Eeles, Tokhir Dadaev, Malgorzata Tymrakiewicz, David E. Goldgar, Chee L. Goh, Zsofia Kote-Jarai, N. Mahmud, Daniel Leongamornlert, Lynne T. O'Brien
Publikováno v: British Journal of Cancer
Background: Prostate cancer (PrCa) is one of the most common cancers affecting men but its aetiology is poorly understood. Family history of PrCa, particularly at a young age, is a strong risk factor. There have been previous reports of increased PrC
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d87b2105c4eec890abec324e233b49d0
http://europepmc.org/articles/PMC3349179
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6
Dietary fat and early-onset prostate cancer risk
Autor: Jo-Fen Liu, Richard Pocock, Elizabeth Page, Rosemary A. Wilkinson, Michelle Guy, Emma J. Sawyer, Rosalind A. Eeles, Artitaya Lophatananon, Douglas F. Easton, Jane Archer, Zsofia Kote-Jarai, Sandra Barratt, Kenneth Muir, Aneela Atta Ur Rahman, Amanda L. Hall, David P. Dearnaley, Lynne T. O'Brien
Publikováno v: British Journal of Nutrition. 103:1375-1380
The UK incidence of prostate cancer has been increasing in men aged v. lowest quintile of intake of total fat, SFA, MUFA and PUFA was observed when adjusted for confounding variables: OR 2·53 (95 % CI 1·72, 3·74), OR 2·49 (95 % CI 1·69, 3·66),
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::def9f6e7bedc4a6dde70bc8a3fc58bb0
https://doi.org/10.1017/s0007114509993291
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7
Mutation analysis of the MSMB gene in familial prostate cancer
Autor: Rosemary A. Wilkinson, Michelle Guy, Rosalind A. Eeles, A A Al Olama, Daniel Leongamornlert, David E. Neal, Zsofia Kote-Jarai, Jenny L Donovan, Emma J. Sawyer, Doug Easton, Malgorzata Tymrakiewicz, Kenneth Muir, Amanda L. Hall, Lynne T. O'Brien, Jonathan J. Morrison, Freddie C. Hamdy
Publikováno v: British Journal of Cancer
Background: MSMB, a gene coding for β-microseminoprotein, has been identified as a candidate susceptibility gene for prostate cancer (PrCa) in two genome-wide association studies (GWAS). SNP rs10993994 is 2 bp upstream of the transcription initiatio
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::087e2a0f09352f415b79f24f0a3ae6c6
http://europepmc.org/articles/PMC2816656
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8
Identification of seven new prostate cancer susceptibility loci through a genome-wide association study
Autor: Jo Fen Liu, Timothy R. Rebbeck, Brian E. Henderson, Vincent Khoo, Lynne T. O'Brien, Anna M. Ray, Klara Stefflova, Ethan M. Lange, Joanne L. Dickinson, Shannon K. McDonnell, Sarah J Lewis, Amit Joshi, Thilo Dörk, Jyotsna Batra, Yong-Jie Lu, Manuel Luedeke, Rosemary A. Wilkinson, Michelle Guy, C. R. J. Woodhouse, David E. Neal, Christopher A. Haiman, Gianluca Severi, Liesel M. FitzGerald, Audrey Ardern-Jones, Douglas F. Easton, Erika M. Kwon, Colin Cooper, Dallas R. English, Kathleen A. Cooney, Daniel Leongamornlert, Graham G. Giles, Loic Le Marchand, Laurence N. Kolonel, C. Slavov, Daniel J. Schaid, Ahva Shahabi, Suzanne K. Chambers, Teuvo L.J. Tammela, Jong Y. Park, Johanna Schleutker, Robert Huddart, Melissa C. Southey, Sue A. Ingles, Tim Christmas, Judith A. Clements, Mary-Anne Kedda, Malgorzata Tymrakiewicz, David P. Dearnaley, Radka Kaneva, Edward J. Saunders, Thomas A. Sellers, Janet L. Stanford, Anssi Auvinen, Alan Thompson, Jonathan J. Morrison, Guangwen Cao, Amanda L. Hall, Humera Khan, Pierre Hutter, Stephen M. Edwards, Esther M. John, Emma J. Sawyer, Angela Cox, Lisa A. Cannon-Albright, Tiina Wahlfors, Pierre O. Chappuis, Stephen N. Thibodeau, Freddie C. Hamdy, Elaine A. Ostrander, Hong Wei Zhang, Nicholas Van As, John L. Hopper, Walther Vogel, Amanda B. Spurdle, Jürgen Serth, Joanne F. Aitken, Chris Ogden, Atanaska Mitkova, Felicity Lose, Zsofia Kote-Jarai, Elizabeth Page, Christiane Maier, Joseph S. Koopmeiners, William D. Foulkes, Kenneth Muir, Alan Horwich, Danielle M. Karyadi, Chris Parker, Briony Patterson, Julio M. Pow-Sang, Robert A. Gardiner, Ali Amin Al Olama, Mariana C. Stern, Roman Corral, Maurice P. Zeegers, Andrea M. Polanowski, Artitaya Lophatananon, Rosalind A. Eeles, Andreas Meyer, J. M. Farnham, Jenny L Donovan
Publikováno v: Nature Genetics, 41(10), 1116-21. Nature Publishing Group
Prostate cancer (PrCa) is the most frequently diagnosed cancer in males in developed countries. To identify common PrCa susceptibility alleles, we previously conducted a genome-wide association study in which 541,129 SNPs were genotyped in 1,854 PrCa
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bba7ec862958c7310199b40974e05bb
https://cris.maastrichtuniversity.nl/en/publications/07d789de-e322-4232-8a52-f7381f8c3cc1
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9
Risk Analysis of Prostate Cancer in PRACTICAL, a Multinational Consortium, Using 25 Known Prostate Cancer Susceptibility Loci
Autor: Karina Dalsgaard Sørensen, Rosemary A. Wilkinson, Jong Y. Park, Johanna Schleutker, Cezary Cybulski, Rosalind A. Eeles, John L. Hopper, Melissa C. Southey, Janet L. Stanford, Torben F. Ørntoft, Radka Kaneva, Jenny L Donovan, Thilo Doerk, Paul D.P. Pharoah, David E. Neal, Hongwei Zhang, Sarah J. Little, Emma J. Sawyer, Nora Pashayan, Tomonori Habuchi, Kathleen Herkommer, Maurice P. Zeegers, Antonis C. Antoniou, Brian E. Henderson, Kenneth Muir, Fredrick R. Schumacher, Charnita Zeigler-Johnson, Koveela Govindasami, Christopher A. Haiman, Freddie C. Hamdy, Judith A. Clements, Jyotsna Batra, Ali Amin Al Olama, Joanne L. Dickinson, Gianluca Severi, Yong-Jie Lu, Maren Weischer, Sara Benlloch, Malgorzata Tymrakiewicz, Edward J. Saunders, Sue A. Ingles, Michelle Guy, Timothy R. Rebbeck, Stephen N. Thibodeau, Zsofia Kote-Jarai, Amanda B. Spurdle, Lisa A. Cannon-Albright, Pierre Hutter, Daniel Leongamornlert, Robert A. Stephenson, Elaine A. Ostrander, Liesel M. FitzGerald, Hermann Brenner, Kathleen A. Cooney, Aritaya Lophatonanon, Antje E. Rinckleb, Angela Cox, Tokhir Dadaev, Pierre O. Chappuis, Børge G. Nordestgaard, William D. Foulkes, Douglas F. Easton, Suzanne K. Chambers, Christiane Maier, Graham G. Giles
Publikováno v: Amin Al Olama, A, Benlloch, S, Antoniou, A C, Giles, G G, Severi, G, Neal, D, Hamdy, F C, Donovan, J L, Muir, K, Schleutker, J, Henderson, B E, Haiman, C, Schumacher, F R, Pashayan, N, Pharoah, P D P, Ostrander, E A, Stanford, J L, Batra, J, Clements, J A, Chambers, S K, Weischer, M, Nordestgaard, B G, Ingles, S A, Sørensen, K D, Orntoft, T F, Park, J Y, Cybulski, C, Maier, C, Doerk, T, Dickinson, J L, Cannon-Albright, L, Brenner, H, Rebbeck, T R, Zeigler-Johnson, C, Habuchi, T, Thibodeau, S N, Cooney, K, Chappuis, P O, Hutter, P, Kaneva, R P, Foulkes, W D, Zeegers, M P, Lu, Y-J, Zhang, H-W, Stephenson, R, Cox, A, Southey, M C, Spurdle, A B, FitzGerald, L, The UK Genetic Prostate Cancer Study Collaborators/British Association of Urological Surgeons' Section of Oncology, The UK ProtecT Study Collaborators & The PRACTICAL Consortium 2015, ' Risk Analysis of Prostate Cancer in PRACTICAL, a Multinational Consortium, Using 25 Known Prostate Cancer Susceptibility Loci ', Cancer Epidemiology, Biomarkers & Prevention, vol. 24, no. 7, pp. 1121-1129 . https://doi.org/10.1158/1055-9965.EPI-14-0317
Cancer Epidemiology Biomarkers & Prevention, 24(7), 1121-1129. American Association for Cancer Research Inc.
Background: Genome-wide association studies have identified multiple genetic variants associated with prostate cancer risk which explain a substantial proportion of familial relative risk. These variants can be used to stratify individuals by their r
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b735ef641c30687965b6a4203b093fa7
https://europepmc.org/articles/PMC4491026/
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