Data from Altered Endosome Biogenesis in Prostate Cancer Has Biomarker Potential

Autor: Doug A. Brooks, Lisa M. Butler, Roberto Weigert, Tetyana Shandala, Emma J. Parkinson-Lawrence, Ian R.D. Johnson

Prostate cancer is the second most common form of cancer in males, affecting one in eight men by the time they reach the age of 70 years. Current diagnostic tests for prostate cancer have significant problems with both false negatives and false posit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f23367e06e7f57d112fae9e0b3bed21f
https://doi.org/10.1158/1541-7786.c.6539955.v1

Increased Alveolar Heparan Sulphate and Reduced Pulmonary Surfactant Amount and Function in the Mucopolysaccharidosis IIIA Mouse

Autor: Tamara L. Paget, Emma J. Parkinson-Lawrence, Paul J. Trim, Chiara Autilio, Madhuriben H. Panchal, Grielof Koster, Mercedes Echaide, Marten F. Snel, Anthony D. Postle, Janna L. Morrison, Jésus Pérez-Gil, Sandra Orgeig

Publikováno v: Cells, Vol 10, Iss 4, p 849 (2021)

Mucopolysaccharidosis IIIA (MPS IIIA) is a lysosomal storage disease with significant neurological and skeletal pathologies. Respiratory dysfunction is a secondary pathology contributing to mortality in MPS IIIA patients. Pulmonary surfactant is cruc

Externí odkaz: https://doaj.org/article/303771f4fc134b0c98d59b93b6277ab1

Increased Alveolar Heparan Sulphate and Reduced Pulmonary Surfactant Amount and Function in the Mucopolysaccharidosis IIIA Mouse

Autor: Sandra Orgeig, Grielof Koster, Marten F. Snel, Mercedes Echaide, Emma J. Parkinson-Lawrence, Paul J. Trim, Chiara Autilio, Tamara L. Paget, Janna L. Morrison, Madhuriben H. Panchal, Jesús Pérez-Gil, Anthony D. Postle

Publikováno v: Cells, Vol 10, Iss 849, p 849 (2021)
E-Prints Complutense. Archivo Institucional de la UCM
instname
E-Prints Complutense: Archivo Institucional de la UCM
Universidad Complutense de Madrid
Cells
Volume 10
Issue 4

Mucopolysaccharidosis IIIA (MPS IIIA) is a lysosomal storage disease with significant neurological and skeletal pathologies. Respiratory dysfunction is a secondary pathology contributing to mortality in MPS IIIA patients. Pulmonary surfactant is cruc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::660afcfd44ba85fe52ddfea5d3ed3256
https://www.mdpi.com/2073-4409/10/4/849

CDKI-73 is a Novel Pharmacological Inhibitor of Rab11 Cargo Delivery and Innate Immune Secretion

Autor: Stavros Selemidis, Alexandra Sorvina, Douglas A. Brooks, Emma J. Parkinson-Lawrence, Shudong Wang, David J. Sharkey, Tetyana Shandala

Publikováno v: Cells
Volume 9
Issue 2
Cells, Vol 9, Iss 2, p 372 (2020)

Innate immunity is critical for host defence against pathogen and environmental challenge and this involves the production and secretion of immune mediators, such as antimicrobial peptides and pro-inflammatory cytokines. However, when dysregulated, i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a1366b09419b8d657589237358a59ee

The role of surfactant and distal lung dysfunction in the pathology of lysosomal storage diseases

Autor: Emma J. Parkinson-Lawrence, Tamara L. Paget, Sandra Orgeig

Publikováno v: Current Opinion in Physiology. 23:100467

Refereed/Peer-reviewed Respiratory dysfunction in lysosomal storage diseases (LSD) is primarily attributed to pulmonary obstruction due to the deposition of storage material in the upper and lower airways. In addition, skeletal deformities may contri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1080a09e3e13193e0d9a0532d550a194
https://doi.org/10.1016/j.cophys.2021.100467