Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Emma J. Grant"'
High glycemic variability is associated with a reduced T cell cytokine response to influenza A virus
Autor:
Marcus Z.W. Tong, Katina D. Hulme, Soi Cheng Law, Ellesandra Noye, Emily S. Dorey, Keng Yih Chew, Louise C. Rowntree, Carolien E. van de Sandt, Katherine Kedzierska, Marco Goeijenbier, Katharina Ronacher, Fawaz Alzaid, Jean-Baptiste Julla, Jean-Pierre Riveline, Katie E. Lineburg, Corey Smith, Emma J. Grant, Stephanie Gras, Linda A. Gallo, Helen L. Barrett, Kirsty R. Short
Publikováno v:
iScience, Vol 27, Iss 11, Pp 111166- (2024)
Summary: Diabetes mellitus significantly increases the risk of severe respiratory virus disease like influenza and COVID-19. Early evidence suggests that this susceptibility to respiratory viral disease is driven by glycemic variability, rather than
Externí odkaz:
https://doaj.org/article/e64ff09be3ce403f9aed6cdf25f703ff
Autor:
You Min Ahn, Janesha C. Maddumage, Emma J. Grant, Demetra S.M. Chatzileontiadou, W.W.J. Gihan Perera, Brian M. Baker, Christopher Szeto, Stephanie Gras
Publikováno v:
Current Research in Structural Biology, Vol 7, Iss , Pp 100148- (2024)
CD8+ T cells are crucial for viral elimination and recovery from viral infection. Nonetheless, the current understanding of the T cell response to SARS-CoV-2 at the antigen level remains limited. The Spike protein is an external structural protein th
Externí odkaz:
https://doaj.org/article/8532197134a44c818e511779c5cc34a4
Autor:
Emma J. Grant, Stephanie Gras
Publikováno v:
STAR Protocols, Vol 3, Iss 3, Pp 101590- (2022)
Summary: Directly ex vivo, peptide-specific CD8+ T cells are present at relatively low frequency and are typically in a resting state. This protocol details the expansion of memory peptide-specific CD8+ T cells by in vitro stimulation, which can be s
Externí odkaz:
https://doaj.org/article/a4f7a23559f846b09ae30556dc4102c9
Autor:
Andrea T. Nguyen, Christopher Szeto, Dhilshan Jayasinghe, Christian A. Lobos, Hanim Halim, Demetra S. M. Chatzileontiadou, Emma J. Grant, Stephanie Gras
Publikováno v:
Biophysica, Vol 1, Iss 2, Pp 194-203 (2021)
The SARS-CoV-2 virus responsible for the COVID-19 pandemic has caused significant morbidity and mortality worldwide. With the remarkable advances in medical research, vaccines were developed to prime the human immune system and decrease disease sever
Externí odkaz:
https://doaj.org/article/cf3da1f68d4a451a9513421d801902a3
Autor:
Luca Hensen, Patricia T. Illing, E. Bridie Clemens, Thi H. O. Nguyen, Marios Koutsakos, Carolien E. van de Sandt, Nicole A. Mifsud, Andrea T. Nguyen, Christopher Szeto, Brendon Y. Chua, Hanim Halim, Simone Rizzetto, Fabio Luciani, Liyen Loh, Emma J. Grant, Phillipa M. Saunders, Andrew G. Brooks, Steve Rockman, Tom C. Kotsimbos, Allen C. Cheng, Michael Richards, Glen P. Westall, Linda M. Wakim, Thomas Loudovaris, Stuart I. Mannering, Michael Elliott, Stuart G. Tangye, David C. Jackson, Katie L. Flanagan, Jamie Rossjohn, Stephanie Gras, Jane Davies, Adrian Miller, Steven Y. C. Tong, Anthony W. Purcell, Katherine Kedzierska
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
The immunology of Indigenous populations is generally understudied outside the context of diseases that are prevalent in these communities. Here the authors identify prevalence of influenza CD8+ T cell epitopes in an Indigenous Australian population
Externí odkaz:
https://doaj.org/article/a3a6a4c017e544c7b83819f5cde0c3d5
Autor:
Srividhya Swaminathan, Katie E. Lineburg, George R. Ambalathingal, Pauline Crooks, Emma J. Grant, Sonali V. Mohan, Jyothy Raju, Archana Panikkar, Laetitia Le Texier, Zheng Wei Marcus Tong, Keng Yih Chew, Michelle A. Neller, Kirsty R. Short, Harsha Gowda, Stephanie Gras, Rajiv Khanna, Corey Smith
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 1 (2022)
ABSTRACT Understanding the immune response to severe acute respiratory syndrome coronavirus (SARS-CoV-2) is critical to overcome the current coronavirus disease (COVID-19) pandemic. Efforts are being made to understand the potential cross-protective
Externí odkaz:
https://doaj.org/article/5709553592884cb3bf3c0e9822016b65
Autor:
Emma J. Grant, Tracy M. Josephs, Liyen Loh, E. Bridie Clemens, Sneha Sant, Mandvi Bharadwaj, Weisan Chen, Jamie Rossjohn, Stephanie Gras, Katherine Kedzierska
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Mutations within immunological epitope containing regions of influenza A virus can impair the established immune response between influenza strains and could impact rational vaccine design. Here Grant et al. examine the presence, structural impact an
Externí odkaz:
https://doaj.org/article/e3208577560a455ba744a1baab24971d
Autor:
Christopher Szeto, Demetra S.M. Chatzileontiadou, Andrea T. Nguyen, Hannah Sloane, Christian A. Lobos, Dhilshan Jayasinghe, Hanim Halim, Corey Smith, Alan Riboldi-Tunnicliffe, Emma J. Grant, Stephanie Gras
Publikováno v:
iScience, Vol 24, Iss 2, Pp 102096- (2021)
Summary: CD8+ T cells are crucial for anti-viral immunity; however, understanding T cell responses requires the identification of epitopes presented by human leukocyte antigens (HLA). To date, few SARS-CoV-2-specific CD8+ T cell epitopes have been de
Externí odkaz:
https://doaj.org/article/f7bd7dd092ad4210939403cdcb929a33
Autor:
Christopher Szeto, Andrea T. Nguyen, Christian A. Lobos, Demetra S. M. Chatzileontiadou, Dhilshan Jayasinghe, Emma J. Grant, Alan Riboldi-Tunnicliffe, Corey Smith, Stephanie Gras
Publikováno v:
Cells, Vol 10, Iss 10, p 2646 (2021)
The data currently available on how the immune system recognises the SARS-CoV-2 virus is growing rapidly. While there are structures of some SARS-CoV-2 proteins in complex with antibodies, which helps us understand how the immune system is able to re
Externí odkaz:
https://doaj.org/article/65333e86f5364b86801ecd5353f45ef1
Autor:
Oscar L. Haigh, Emma J. Grant, Thi H. O. Nguyen, Katherine Kedzierska, Matt A. Field, John J. Miles
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 4, p 1625 (2021)
The distinct properties of allo-reactive T-cell repertoires are not well understood. To investigate whether auto-reactive and allo-reactive T-cell repertoires encoded distinct properties, we used dextramer enumeration, enrichment, single-cell T-cell
Externí odkaz:
https://doaj.org/article/b1b2400b979b46e7a0a1df20b95546da