A qualitative study of the barriers to using blinding in in vivo experiments and suggestions for improvement.

Autor: Natasha A Karp, Esther J Pearl, Emma J Stringer, Chris Barkus, Jane Coates Ulrichsen, Nathalie Percie du Sert

Publikováno v: PLoS Biology, Vol 20, Iss 11, p e3001873 (2022)

In animal experiments, blinding (also known as masking) is a methodological strategy to reduce the risk that scientists, animal care staff, or other staff involved in the research may consciously or subconsciously influence the outcome. Lack of maski

Externí odkaz: https://doaj.org/article/7461b4dc09c448b380ff7d1669a64c23

The

Autor: Elisavet, Karamanavi, David G, McVey, Sander W, van der Laan, Paulina J, Stanczyk, Gavin E, Morris, Yifan, Wang, Wei, Yang, Kenneth, Chan, Robin N, Poston, Jun, Luo, Xinmiao, Zhou, Peng, Gong, Peter D, Jones, Junjun, Cao, Renata B, Kostogrys, Tom R, Webb, Gerard, Pasterkamp, Haojie, Yu, Qingzhong, Xiao, Peter A, Greer, Emma J, Stringer, Nilesh J, Samani, Shu, Ye

Publikováno v: Circulation research. 131(12)

Genome-wide association studies have discovered a link between genetic variants on human chromosome 15q26.1 and increased coronary artery disease (CAD) susceptibility; however, the underlying pathobiological mechanism is unclear. This genetic locus c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::33c10e34ff9a9b3fca56252495b255c9
https://pubmed.ncbi.nlm.nih.gov/36321446

A preclinical ultrasound method for the assessment of vascular disease progression in murine models

Autor: Michael E. Kelly, Baris Kanber, Emma J. Stringer, Justyna Janus, Charlotte Beynon, David G. Lambert, Wadhah Mahbuba, Kumar V. Ramnarine, Nilesh J. Samani

Publikováno v: Ultrasound

Introduction The efficacy of preclinical ultrasound at providing a quantitative assessment of mouse models of vascular disease is relatively unknown. In this study, preclinical ultrasound was used in combination with a semi-automatic image processing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81c820a8e55938da2fab243fdd4095d6
https://doi.org/10.1177/1742271x18793919

A The Coronary Artery Disease Associated Gene HHIPL1 Promotes Atherosclerosis

Autor: Elisavet Karamanavi, Nilesh J. Samani, Tom R. Webb, Sarah L. Andrews, Dimitra Aravani, Emma J. Stringer

Publikováno v: Heart. 102:A145-A146

Genome-wide association studies have identified chromosome 14q32 as a locus for coronary artery disease in humans. The disease associated variants fall in a gene called Hedgehog interacting protein-like 1 (HHIPL1), which encodes an uncharacterised se

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9674e9f069f418df4d7b5840b08896cf
https://doi.org/10.1136/heartjnl-2016-309890.220

Concerted involvement of Cdx/Hox genes and Wnt signaling in morphogenesis of the caudal neural tube and cloacal derivatives from the posterior growth zone

Autor: Felix Beck, Jacqueline Deschamps, Frits Meijlink, Roel Neijts, Jennifer E. Rowland, Teddy Young, Moisés Mallo, Ana Nóvoa, Jean-Noël Freund, Monika Bialecka, Carina van Rooijen, Emma J. Stringer, Cesca van de Ven

Publikováno v: Development (Cambridge, England)
Development (Cambridge, England), Company of Biologists, 2011, 138 (16), pp.3451-3462. ⟨10.1242/dev.066118⟩
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Development, 138(16), 3451-3462. Company of Biologists Ltd

Decrease in Cdx dosage in an allelic series of mouse Cdx mutants leads to progressively more severe posterior vertebral defects. These defects are corrected by posterior gain of function of the Wnt effector Lef1. Precocious expression of Hox paralogo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4885c1466c6e0ca844106e952d46dcc8
https://hdl.handle.net/10400.7/644