Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Emma J, Radcliffe"'
Autor:
Emma J. Radcliffe, Charles M. Pearman, Amy Watkins, Michael Lawless, Graeme J. Kirkwood, Sophie N. Saxton, David A. Eisner, Andrew W. Trafford
Publikováno v:
Physiological Reports, Vol 8, Iss 2, Pp n/a-n/a (2020)
Abstract Autonomic dysregulation plays a key role in the development and progression of heart failure (HF). Vagal nerve stimulation (VNS) may be a promising therapeutic approach. However, the outcomes from clinical trials evaluating VNS in HF have be
Externí odkaz:
https://doaj.org/article/94a805943b3141dc99028ded915d88c6
Ischaemic heart disease remains a leading cause of premature mortality and morbidity. Understanding the associated pathophysiological mechanisms of cardiac dysfunction arising from ischaemic heart disease and the identification of sites of novel ther
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f7394faf6ea814bcada863b1d8af3e4
https://doi.org/10.1101/2023.03.02.530817
https://doi.org/10.1101/2023.03.02.530817
Autor:
Charles M. Pearman, George W.P. Madders, Emma J. Radcliffe, Graeme J. Kirkwood, Michael Lawless, Amy Watkins, Charlotte E.R. Smith, Andrew W. Trafford, David A. Eisner, Katharine M. Dibb
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 7, Iss 23 (2018)
Background Atrial fibrillation (AF) is common in the elderly, but rare in the young; however, the changes that occur with age that promote AF are not fully understood. Action potential (AP) alternans may be involved in the initiation of AF. Using a t
Externí odkaz:
https://doaj.org/article/f7e1341037234cee820cd751d17b30eb
Autor:
Tharushi Perera, Charlene Pius, Barbara Niort, Emma J. Radcliffe, Katharine M. Dibb, Andrew W. Trafford, Christian Pinali
Publikováno v:
Philosophical Transactions of the Royal Society B: Biological Sciences. 377
The highly organized transverse tubule (t-tubule) network facilitates cardiac excitation–contraction coupling and synchronous cardiac myocyte contraction. In cardiac failure secondary to myocardial infarction (MI), changes in the structure and orga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::674b23af15cc4d17ae3e7793d5742ed4
https://doi.org/10.1098/rstb.2021.0331
https://doi.org/10.1098/rstb.2021.0331
Autor:
David A. Eisner, Christian Pinali, Emma J. Radcliffe, Charles M. Pearman, Katharine M. Dibb, Charlotte E.R. Smith, Andrew W. Trafford, Amy E. Watkins, Margaux A. Horn, Jessica D. Clarke, Jessica L. Caldwell, Elizabeth F. Bode, Mark Eisner, Aiste Adomaviciene, Callum J. Quinn
Transverse (t)-tubules drive the rapid and synchronous Ca2+ rise in cardiac myocytes. The virtual complete loss of atrial t-tubules in heart failure (HF) decreases Ca2+ release. It is unknown if or how atrial t-tubules can be restored and if restored
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a02108dfbd18274c30eadfa093f6d108
https://doi.org/10.1101/2021.10.28.466162
https://doi.org/10.1101/2021.10.28.466162
Autor:
Michael Lawless, Jessica L. Caldwell, Emma J. Radcliffe, Charlotte E. R. Smith, George W. P. Madders, David C. Hutchings, Lori S. Woods, Stephanie J. Church, Richard D. Unwin, Graeme J. Kirkwood, Lorenz K. Becker, Charles M. Pearman, Rebecca F. Taylor, David A. Eisner, Katharine M. Dibb, Andrew. W. Trafford
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-17 (2019)
Heart failure (HF) is characterized by poor survival, a loss of catecholamine reserve and cellular structural remodeling in the form of disorganization and loss of the transverse tubule network. Indeed, survival rates for HF are worse than many commo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doajarticles::39b864b136f1cfa983f35c432c563617
http://link.springer.com/article/10.1038/s41598-019-42592-1
http://link.springer.com/article/10.1038/s41598-019-42592-1
BS9 Regional alterations to the transverse-tubule network in an ovine model of myocardial infarction
Autor:
Andrew W. Trafford, Emma J. Radcliffe, Charlene Pius, Barbara Niort, Christian Pinali, Tharushi Perera
Publikováno v:
Basic science.
The highly organised transverse tubule (t-tubule) network consisting of invaginations of the cell sarcolemma facilitates synchronous cardiac myocyte contraction. This study aimed to investigate post-myocardial infarction (MI) t-tubule remodelling in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::38e05dce7ab291acb14a003c4a8ed59c
https://doi.org/10.1136/heartjnl-2021-bcs.207
https://doi.org/10.1136/heartjnl-2021-bcs.207
Autor:
Graeme Kirkwood, David A. Eisner, Michael Lawless, Emma J. Radcliffe, Charles M. Pearman, Amy Watkins, Andrew W. Trafford, Sophie N Saxton
Publikováno v:
Physiological Reports, Vol 8, Iss 2, Pp n/a-n/a (2020)
Physiological Reports
Radcliffe, E, Pearman, C, Watkins, A, Lawless, M, Kirkwood, G, Saxton, S, Eisner, D & Trafford, A 2020, ' Chronic vagal nerve stimulation has no effect on tachycardia-induced heart failure progression or excitation-contraction coupling ', Physiological Reports, vol. 8, no. 2, e14321 . https://doi.org/10.14814/phy2.14321
Physiological Reports
Radcliffe, E, Pearman, C, Watkins, A, Lawless, M, Kirkwood, G, Saxton, S, Eisner, D & Trafford, A 2020, ' Chronic vagal nerve stimulation has no effect on tachycardia-induced heart failure progression or excitation-contraction coupling ', Physiological Reports, vol. 8, no. 2, e14321 . https://doi.org/10.14814/phy2.14321
Autonomic dysregulation plays a key role in the development and progression of heart failure (HF). Vagal nerve stimulation (VNS) may be a promising therapeutic approach. However, the outcomes from clinical trials evaluating VNS in HF have been mixed,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcea26ad994016fa6d4776f375c0fb80
https://doaj.org/article/94a805943b3141dc99028ded915d88c6
https://doaj.org/article/94a805943b3141dc99028ded915d88c6
Publikováno v:
Abstracts.
The availability of ATP is a limiting factor to cardiac contraction. ATP is predominantly produced by mitochondria via oxidative phosphorylation. Nitric oxide acts as a competitive inhibitor of complex IV and following ischemia, S-nitrosylation has b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::60a01e2582f11e6d9af3cfe904283b73
https://doi.org/10.1136/heartjnl-2018-bscr.30
https://doi.org/10.1136/heartjnl-2018-bscr.30
Autor:
Charles M. Pearman, George W.P. Madders, Richard D. Unwin, David A. Eisner, Graeme Kirkwood, Michael Lawless, Andrew W. Trafford, Charlotte E.R. Smith, Lori Woods, Lorenz K. Becker, David Hutchings, Emma J. Radcliffe, Katharine M. Dibb, Rebecca F. Taylor, Stephanie J. Church, Jessica L. Caldwell
Heart failure is characterized by poor survival, a loss of catecholamine reserve and cellular structural remodeling in the form of disorganization and loss of the transverse tubule network. Indeed, survival rates for heart failure are worse than many
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68b10c533964f5b5757951722d42106a
https://doi.org/10.1101/248187
https://doi.org/10.1101/248187