Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Emma J, Grant"'
High glycemic variability is associated with a reduced T cell cytokine response to influenza A virus
Autor:
Marcus Z.W. Tong, Katina D. Hulme, Soi Cheng Law, Ellesandra Noye, Emily S. Dorey, Keng Yih Chew, Louise C. Rowntree, Carolien E. van de Sandt, Katherine Kedzierska, Marco Goeijenbier, Katharina Ronacher, Fawaz Alzaid, Jean-Baptiste Julla, Jean-Pierre Riveline, Katie E. Lineburg, Corey Smith, Emma J. Grant, Stephanie Gras, Linda A. Gallo, Helen L. Barrett, Kirsty R. Short
Publikováno v:
iScience, Vol 27, Iss 11, Pp 111166- (2024)
Summary: Diabetes mellitus significantly increases the risk of severe respiratory virus disease like influenza and COVID-19. Early evidence suggests that this susceptibility to respiratory viral disease is driven by glycemic variability, rather than
Externí odkaz:
https://doaj.org/article/e64ff09be3ce403f9aed6cdf25f703ff
Autor:
Emma J Grant, Stephanie Gras
Publikováno v:
Clinical & Translational Immunology, Vol 13, Iss 11, Pp n/a-n/a (2024)
Abstract Objectives The recent H5N1 avian influenza outbreak in the USA has sparked fresh fears of avian viruses causing the next pandemic. To date, the H5N1 (clade 2.3.4.4b) outbreak in cattle has spread across several states in the USA, with severa
Externí odkaz:
https://doaj.org/article/7928ca4a4ea2462fa3710399969b2c7c
Autor:
Samuel Liwei Leong, Lawton Murdolo, Janesha C Maddumage, Marios Koutsakos, Katherine Kedzierska, Anthony W Purcell, Stephanie Gras, Emma J Grant
Publikováno v:
Clinical & Translational Immunology, Vol 13, Iss 5, Pp n/a-n/a (2024)
Abstract Objectives Seasonal influenza viruses cause roughly 650 000 deaths annually despite available vaccines. CD8+ T cells typically recognise influenza‐derived peptides from internal structural and non‐structural influenza proteins and are an
Externí odkaz:
https://doaj.org/article/92b22af77c7e4591a45e894d639392e0
Autor:
You Min Ahn, Janesha C. Maddumage, Emma J. Grant, Demetra S.M. Chatzileontiadou, W.W.J. Gihan Perera, Brian M. Baker, Christopher Szeto, Stephanie Gras
Publikováno v:
Current Research in Structural Biology, Vol 7, Iss , Pp 100148- (2024)
CD8+ T cells are crucial for viral elimination and recovery from viral infection. Nonetheless, the current understanding of the T cell response to SARS-CoV-2 at the antigen level remains limited. The Spike protein is an external structural protein th
Externí odkaz:
https://doaj.org/article/8532197134a44c818e511779c5cc34a4
Publikováno v:
Clinical & Translational Immunology, Vol 13, Iss 2, Pp n/a-n/a (2024)
Abstract Seasonal influenza viruses continue to cause severe medical and financial complications annually. Although there are many licenced influenza vaccines, there are billions of cases of influenza infection every year, resulting in the death of o
Externí odkaz:
https://doaj.org/article/0f03683b38464fcaacd194674c90963a
Autor:
Emma J. Grant, Stephanie Gras
Publikováno v:
STAR Protocols, Vol 3, Iss 3, Pp 101590- (2022)
Summary: Directly ex vivo, peptide-specific CD8+ T cells are present at relatively low frequency and are typically in a resting state. This protocol details the expansion of memory peptide-specific CD8+ T cells by in vitro stimulation, which can be s
Externí odkaz:
https://doaj.org/article/a4f7a23559f846b09ae30556dc4102c9
Autor:
Andrea T. Nguyen, Christopher Szeto, Dhilshan Jayasinghe, Christian A. Lobos, Hanim Halim, Demetra S. M. Chatzileontiadou, Emma J. Grant, Stephanie Gras
Publikováno v:
Biophysica, Vol 1, Iss 2, Pp 194-203 (2021)
The SARS-CoV-2 virus responsible for the COVID-19 pandemic has caused significant morbidity and mortality worldwide. With the remarkable advances in medical research, vaccines were developed to prime the human immune system and decrease disease sever
Externí odkaz:
https://doaj.org/article/cf3da1f68d4a451a9513421d801902a3
Autor:
Luca Hensen, Patricia T. Illing, E. Bridie Clemens, Thi H. O. Nguyen, Marios Koutsakos, Carolien E. van de Sandt, Nicole A. Mifsud, Andrea T. Nguyen, Christopher Szeto, Brendon Y. Chua, Hanim Halim, Simone Rizzetto, Fabio Luciani, Liyen Loh, Emma J. Grant, Phillipa M. Saunders, Andrew G. Brooks, Steve Rockman, Tom C. Kotsimbos, Allen C. Cheng, Michael Richards, Glen P. Westall, Linda M. Wakim, Thomas Loudovaris, Stuart I. Mannering, Michael Elliott, Stuart G. Tangye, David C. Jackson, Katie L. Flanagan, Jamie Rossjohn, Stephanie Gras, Jane Davies, Adrian Miller, Steven Y. C. Tong, Anthony W. Purcell, Katherine Kedzierska
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
The immunology of Indigenous populations is generally understudied outside the context of diseases that are prevalent in these communities. Here the authors identify prevalence of influenza CD8+ T cell epitopes in an Indigenous Australian population
Externí odkaz:
https://doaj.org/article/a3a6a4c017e544c7b83819f5cde0c3d5
Autor:
Srividhya Swaminathan, Katie E. Lineburg, George R. Ambalathingal, Pauline Crooks, Emma J. Grant, Sonali V. Mohan, Jyothy Raju, Archana Panikkar, Laetitia Le Texier, Zheng Wei Marcus Tong, Keng Yih Chew, Michelle A. Neller, Kirsty R. Short, Harsha Gowda, Stephanie Gras, Rajiv Khanna, Corey Smith
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 1 (2022)
ABSTRACT Understanding the immune response to severe acute respiratory syndrome coronavirus (SARS-CoV-2) is critical to overcome the current coronavirus disease (COVID-19) pandemic. Efforts are being made to understand the potential cross-protective
Externí odkaz:
https://doaj.org/article/5709553592884cb3bf3c0e9822016b65
Autor:
Andrea T Nguyen, Hiu Ming Peter Lau, Hannah Sloane, Dhilshan Jayasinghe, Nicole A Mifsud, Demetra SM Chatzileontiadou, Emma J Grant, Christopher Szeto, Stephanie Gras
Publikováno v:
Clinical & Translational Immunology, Vol 11, Iss 10, Pp n/a-n/a (2022)
Abstract Objective Influenza A, B and C viruses (IAV, IBV and ICV, respectively) circulate globally, infecting humans and causing widespread morbidity and mortality. Here, we investigate the T cell response towards an immunodominant IAV epitope, NP26
Externí odkaz:
https://doaj.org/article/ccaeebb4c0aa433983c8414d302819ae