Pregnancy-Associated Cancer: A Systematic Review and Meta-Analysis

Autor: Ben Walters, MBChB, India Midwinter, BSc, MBBS, Carolyn A. Chew-Graham, MBChB, MD, Kelvin P. Jordan, PhD, Garima Sharma, MB, Lucy C. Chappell, MB, BCh, PhD, Emma J. Crosbie, MBChB, PhD, Purvi Parwani, MBBS, MPH, Mamas A. Mamas, BM BCh, DPhil, Pensée Wu, MBChB, MD(Res)

Publikováno v: Mayo Clinic Proceedings: Innovations, Quality & Outcomes, Vol 8, Iss 2, Pp 188-199 (2024)

This study aimed to systematically evaluate and quantify the risk of adverse maternal and neonatal outcomes in patients with pregnancy-associated cancer (PAC). This study was conducted from February 13, 2021, through July 24, 2023. A systematic searc

Externí odkaz: https://doaj.org/article/8bc42a0d86a3458a8a78d7ff9fde62d3

Detection of endometrial cancer in cervico-vaginal fluid and blood plasma: leveraging proteomics and machine learning for biomarker discoveryResearch in context

Autor: Kelechi Njoku, Andrew Pierce, Davide Chiasserini, Bethany Geary, Amy E. Campbell, Janet Kelsall, Rachel Reed, Nophar Geifman, Anthony D. Whetton, Emma J. Crosbie

Publikováno v: EBioMedicine, Vol 102, Iss , Pp 105064- (2024)

Summary: Background: The anatomical continuity between the uterine cavity and the lower genital tract allows for the exploitation of uterine-derived biomaterial in cervico-vaginal fluid for endometrial cancer detection based on non-invasive sampling

Externí odkaz: https://doaj.org/article/aa9847fd599d4a019d13e4ed6f2270e2

Clinical trials in cancer screening, prevention and early diagnosis (SPED): a systematic mapping review

Autor: Emma L. O’Dowd, Samuel W. D. Merriel, Vinton W. T. Cheng, Sam Khan, Lynne M. Howells, Dipesh P. Gopal, Elizabeth A. Roundhill, Paul M. Brennan, Philip A. J. Crosbie, Richard D. Neal, Karen Brown, Emma J. Crosbie, David R. Baldwin

Publikováno v: BMC Cancer, Vol 23, Iss 1, Pp 1-11 (2023)

Abstract Background Global annual cancer incidence is forecast to rise to 27.5 M by 2040, a 62% increase from 2018. For most cancers, prevention and early detection are the most effective ways of reducing mortality. This study maps trials in cancer s

Externí odkaz: https://doaj.org/article/1225c6be837041a58d5618e2cacd19b9

Colorectal cancer incidences in Lynch syndrome: a comparison of results from the prospective lynch syndrome database and the international mismatch repair consortium

Autor: Pål Møller, Toni Seppälä, James G. Dowty, Saskia Haupt, Mev Dominguez-Valentin, Lone Sunde, Inge Bernstein, Christoph Engel, Stefan Aretz, Maartje Nielsen, Gabriel Capella, Dafydd Gareth Evans, John Burn, Elke Holinski-Feder, Lucio Bertario, Bernardo Bonanni, Annika Lindblom, Zohar Levi, Finlay Macrae, Ingrid Winship, John-Paul Plazzer, Rolf Sijmons, Luigi Laghi, Adriana Della Valle, Karl Heinimann, Elizabeth Half, Francisco Lopez-Koestner, Karin Alvarez-Valenzuela, Rodney J. Scott, Lior Katz, Ido Laish, Elez Vainer, Carlos Alberto Vaccaro, Dirce Maria Carraro, Nathan Gluck, Naim Abu-Freha, Aine Stakelum, Rory Kennelly, Des Winter, Benedito Mauro Rossi, Marc Greenblatt, Mabel Bohorquez, Harsh Sheth, Maria Grazia Tibiletti, Leonardo S. Lino-Silva, Karoline Horisberger, Carmen Portenkirchner, Ivana Nascimento, Norma Teresa Rossi, Leandro Apolinário da Silva, Huw Thomas, Attila Zaránd, Jukka-Pekka Mecklin, Kirsi Pylvänäinen, Laura Renkonen-Sinisalo, Anna Lepisto, Päivi Peltomäki, Christina Therkildsen, Lars Joachim Lindberg, Ole Thorlacius-Ussing, Magnus von Knebel Doeberitz, Markus Loeffler, Nils Rahner, Verena Steinke-Lange, Wolff Schmiegel, Deepak Vangala, Claudia Perne, Robert Hüneburg, Aída Falcón de Vargas, Andrew Latchford, Anne-Marie Gerdes, Ann-Sofie Backman, Carmen Guillén-Ponce, Carrie Snyder, Charlotte K. Lautrup, David Amor, Edenir Palmero, Elena Stoffel, Floor Duijkers, Michael J. Hall, Heather Hampel, Heinric Williams, Henrik Okkels, Jan Lubiński, Jeanette Reece, Joanne Ngeow, Jose G. Guillem, Julie Arnold, Karin Wadt, Kevin Monahan, Leigha Senter, Lene J. Rasmussen, Liselotte P. van Hest, Luigi Ricciardiello, Maija R. J. Kohonen-Corish, Marjolijn J. L. Ligtenberg, Melissa Southey, Melyssa Aronson, Mohd N. Zahary, N. Jewel Samadder, Nicola Poplawski, Nicoline Hoogerbrugge, Patrick J. Morrison, Paul James, Grant Lee, Rakefet Chen-Shtoyerman, Ravindran Ankathil, Rish Pai, Robyn Ward, Susan Parry, Tadeusz Dębniak, Thomas John, Thomas van Overeem Hansen, Trinidad Caldés, Tatsuro Yamaguchi, Verónica Barca-Tierno, Pilar Garre, Giulia Martina Cavestro, Jürgen Weitz, Silke Redler, Reinhard Büttner, Vincent Heuveline, John L. Hopper, Aung Ko Win, Noralane Lindor, Steven Gallinger, Loïc Le Marchand, Polly A. Newcomb, Jane Figueiredo, Daniel D. Buchanan, Stephen N. Thibodeau, Sanne W. ten Broeke, Eivind Hovig, Sigve Nakken, Marta Pineda, Nuria Dueñas, Joan Brunet, Kate Green, Fiona Lalloo, Katie Newton, Emma J. Crosbie, Miriam Mints, Douglas Tjandra, Florencia Neffa, Patricia Esperon, Revital Kariv, Guy Rosner, Walter Hernán Pavicic, Pablo Kalfayan, Giovana Tardin Torrezan, Thiago Bassaneze, Claudia Martin, Gabriela Moslein, Aysel Ahadova, Matthias Kloor, Julian R. Sampson, Mark A. Jenkins, The European Hereditary Tumour Group (EHTG) and the International Mismatch Repair Consortium (IMRC)

Publikováno v: Hereditary Cancer in Clinical Practice, Vol 20, Iss 1, Pp 1-11 (2022)

Abstract Objective To compare colorectal cancer (CRC) incidences in carriers of pathogenic variants of the MMR genes in the PLSD and IMRC cohorts, of which only the former included mandatory colonoscopy surveillance for all participants. Methods CRC

Externí odkaz: https://doaj.org/article/b931c1477d4f40ef8fbc4e978abfdf69

Immune checkpoint inhibitors efficacy across solid cancers and the utility of PD-L1 as a biomarker of response: a systematic review and meta-analysis

Autor: Timothy S. Fitzsimmons, Niharika Singh, Thomas D. J. Walker, Claire Newton, Dafydd G. R. Evans, Emma J. Crosbie, Neil A. J. Ryan

Publikováno v: Frontiers in Medicine, Vol 10 (2023)

BackgroundImmune checkpoint inhibitors (ICPI) are a tumor agnostic treatment. However, trials of their use have been site specific. Here we summarize the trial data and explore the utility of programmed death-ligand 1 (PD-L1) expression as a biomarke

Externí odkaz: https://doaj.org/article/e85e6a4434f447a39ab6c4448e66752b