Výsledky vyhledávání - "Emma Ispasanie"

Akademický článek

In vaccinated individuals serum bactericidal activity against B meningococci is abrogated by C5 inhibition but not by inhibition of the alternative complement pathway

Autor: Emma Ispasanie, Lukas Muri, Marc Schmid, Anna Schubart, Christine Thorburn, Natasa Zamurovic, Thomas Holbro, Michael Kammüller, Gerd Pluschke

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

IntroductionSeveral diseases caused by the dysregulation of complement activation can be treated with inhibitors of the complement components C5 and/or C3. However, complement is required for serum bactericidal activity (SBA) against encapsulated Gra

Externí odkaz: https://doaj.org/article/98f0748c5c004296ac5b23564869901e

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Akademický článek

Inhibition of the different complement pathways has varying impacts on the serum bactericidal activity and opsonophagocytosis against Haemophilus influenzae type b

Autor: Lukas Muri, Anna Schubart, Christine Thorburn, Natasa Zamurovic, Thomas Holbro, Michael Kammüller, Gerd Pluschke, Emma Ispasanie

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

Defense against Haemophilus influenzae type b (Hib) is dependent on antibodies and complement, which mediate both serum bactericidal activity (SBA) and opsonophagocytosis. Here we evaluated the influence of capsule-specific antibodies and complement

Externí odkaz: https://doaj.org/article/4b7cdba275ec434c86e39c3f02799783

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Akademický článek

Alternative Complement Pathway Inhibition Does Not Abrogate Meningococcal Killing by Serum of Vaccinated Individuals

Autor: Emma Ispasanie, Lukas Muri, Anna Schubart, Christine Thorburn, Natasa Zamurovic, Thomas Holbro, Michael Kammüller, Gerd Pluschke

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

Dysregulation of complement activation causes a number of diseases, including paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome. These conditions can be treated with monoclonal antibodies (mAbs) that bind to the complement co

Externí odkaz: https://doaj.org/article/738a9b24a2a8447095dcef2b7ca6d73f

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Akademický článek

Alternative Complement Pathway Inhibition Abrogates Pneumococcal Opsonophagocytosis in Vaccine-Naïve, but Not in Vaccinated Individuals

Autor: Lukas Muri, Emma Ispasanie, Anna Schubart, Christine Thorburn, Natasa Zamurovic, Thomas Holbro, Michael Kammüller, Gerd Pluschke

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

To assess the relative contribution of opsonisation by antibodies, classical and alternative complement pathways to pneumococcal phagocytosis, we analyzed killing of pneumococci by human blood leukocytes collected from vaccine-naïve and PCV13-vaccin

Externí odkaz: https://doaj.org/article/b9295bf56f22447e8d94a836689a5a13

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Akademický článek

Spontaneous point mutations in the capsule synthesis locus leading to structural and functional changes of the capsule in serogroup A meningococcal populations

Autor: Emma Ispasanie, Francesca Micoli, Araceli Lamelas, Dominique Keller, Francesco Berti, Riccardo De Ricco, Roberta Di Benedetto, Simona Rondini, Gerd Pluschke

Publikováno v: Virulence, Vol 9, Iss 1, Pp 1138-1149 (2018)

Whole genome sequencing analysis of 100 Neisseria meningitidis serogroup A isolates has revealed that the csaABCD-ctrABCD-ctrEF capsule polysaccharide synthesis locus represents a spontaneous point mutation hotspot. Structural and functional properti

Externí odkaz: https://doaj.org/article/a87de0aba4ed4a468df8f59402df92d0

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Akademický článek

Characterization of vaccine antigens of meningococcal serogroup W isolates from Ghana and Burkina Faso from 2003 to 2009 [v1; ref status: indexed, http://f1000r.es/37h]

Autor: Emma Ispasanie, Gerd Pluschke, Abraham Hodgson, Ali Sie, Calman MacLennan, Oliver Koeberling

Publikováno v: F1000Research, Vol 3 (2014)

Neisseria meningitidis is a major cause of bacterial meningitis and a considerable health problem in the 25 countries of the ‘African Meningitis Belt’ that extends from Senegal in West Africa to Ethiopia in the East. Approximately 80% of cases of

Externí odkaz: https://doaj.org/article/42a9df2331e74181b72e987cf1b05534

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