Distinct antibody responses to SARS-CoV-2 in children and adults across the COVID-19 clinical spectrum

Autor: Rei Matsumoto, Yun Zhu, Emily M. Mace, Michael Chait, Wen-Hsuan W. Lin, Eldad A. Hod, Didier Decimo, Branka Horvat, Matthew R. Baldwin, Steven B. Wells, Stephen A. Ferrara, Stuart P. Weisberg, Julia Davis-Porada, Pranay Dogra, Donna L. Farber, Debora Stelitano, Emma Idzikowski, Flavia Dei Zotti, Cyrille Mathieu, Francesca T. Bovier, Matteo Porotto, Zachary C. Bitan, Sandeep N. Wontakal, Francesca La Carpia, Anne Moscona, Krystalyn E. Hudson, Joshua I. Gray, Thomas J. Connors, Peter A. Szabo, Joshua D. Milner, Maya Meimei Li Poon

Publikováno v: Nature Immunology
Nature Immunology, Nature Publishing Group, 2020, pp.25-31. ⟨10.1038/s41590-020-00826-9⟩
Nature Immunology, 2020, pp.25-31. ⟨10.1038/s41590-020-00826-9⟩
Nat Immunol

International audience; Clinical manifestations of COVID-19 caused by the new coronavirus SARS-CoV-2 are associated with age1,2. Adults develop respiratory symptoms, which can progress to acute respiratory distress syndrome (ARDS) in the most severe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5392d06d54951e78528c4d7092f52e03
https://doi.org/10.1038/s41590-020-00826-9

Dietary iron deficiency impairs the functionality but not generation or establishment of memory T cells following influenza infection

Autor: Marissa C Bradley, Emma Idzikowski, Francesca La Carpia, Joshua I. Gray, Ksenia Rybkina, Rebecca S. Guyer, Kalpana Pethe, Eldad A. Hod, Thomas J. Connors

Publikováno v: The Journal of Immunology. 208:57.03-57.03

Protection from viral respiratory tract infections (VRTIs) is dependent on the activation, differentiation, and maintenance of antigen specific memory T cells. Iron is essential for fundamental metabolic processes in the human body, with iron deficie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5571c7dbb7b835d391eb31fb0af91302
https://doi.org/10.4049/jimmunol.208.supp.57.03

Analysis of respiratory and systemic immune responses in COVID-19 reveals mechanisms of disease pathogenesis

Autor: Matthew Steinle, Pranay Dogra, Michael Chait, Stuart P. Weisberg, Maya M.L. Poon, Jing Zhou, Rei Matsumoto, Emma Idzikowski, Peter A. Sims, Izabela Krupska, Sean Mackay, Andrew J. Yates, Matthew R. Baldwin, Anjali Saqi, Donna L. Farber, Chloé Pasin, Joshua I. Gray, Amy Ku, Sinead E. Morris, Thomas J. Connors, Peter A. Szabo, Steven B. Wells, Julia Davis-Porada

Publikováno v: medRxiv

SUMMARYImmune responses to respiratory viruses like SARS-CoV-2 originate and function in the lung, yet assessments of human immunity are often limited to blood. Here, we conducted longitudinal, high-dimensional profiling of paired airway and blood sa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df4d4b05bcb761c53ef39700fb65f3cc
https://doi.org/10.1101/2020.10.15.20208041

Early dynamic accumulation of tissue resident memory T cells in the human lung during infancy

Autor: Rei Matsumoto, Thomas Connors, Basak Burcu Ural, Rebecca Guyer, Emma Idzikowski, Maya M.L. Poon, Puspa Thapa, Donna L Farber

Publikováno v: The Journal of Immunology. 204:235.2-235.2

Infants exhibit increased susceptibility to viral and bacterial pathogens with pulmonary infections representing one of the top causes of infant mortality worldwide. Optimal protection from pathogens is mediated by coordinated functions of different

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::85fdb9701cc19520ea93d92556393c44
https://doi.org/10.4049/jimmunol.204.supp.235.2