Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Emma Hockly"'
Autor:
Emma Hockly, Jamie Tse, Amy L. Barker, Donna L. Moolman, Jean-Luc Beunard, Adrian P. Revington, Kim Holt, Sunny Sunshine, Hilary Moffitt, Kirupa Sathasivam, Benjamin Woodman, Erich E. Wanker, Philip A.S. Lowden, Gillian P. Bates
Publikováno v:
Neurobiology of Disease, Vol 21, Iss 1, Pp 228-236 (2006)
Huntington's disease (HD) is an inherited progressive neurological disorder for which there is no effective therapy. It is caused by a CAG/polyglutamine repeat expansion that leads to abnormal protein aggregation and deposition in the brain. Several
Externí odkaz:
https://doaj.org/article/75ba9f0ba8f9428e927bdc2c0a4bfe11
Autor:
Donna L. Smith, Ruben Portier, Ben Woodman, Emma Hockly, Amarbirpal Mahal, William E. Klunk, Xiao-Jiang Li, Erich Wanker, Karl D. Murray, Gillian P. Bates
Publikováno v:
Neurobiology of Disease, Vol 8, Iss 6, Pp 1017-1026 (2001)
Huntington's disease (HD) is a late onset neurodegenerative disorder caused by a CAG/polyglutamine (polyQ) repeat expansion. PolyQ aggregates can be detected in the nuclei and processes of neurons in HD patients and mouse models prior to the onset of
Externí odkaz:
https://doaj.org/article/fa08d20b29484b8d8f8a3bbfc905b226
Autor:
Philip A. S. Lowden, Sunny Sunshine, Kim Holt, Hilary Moffitt, Donna L. Moolman, Amy L. Barker, Gillian P. Bates, Kirupa Sathasivam, Benjamin Woodman, Adrian Peter Revington, Jean-Luc Beunard, Emma Hockly, Jamie Tse, Erich E. Wanker
Publikováno v:
Neurobiology of Disease, Vol 21, Iss 1, Pp 228-236 (2006)
Huntington's disease (HD) is an inherited progressive neurological disorder for which there is no effective therapy. It is caused by a CAG/polyglutamine repeat expansion that leads to abnormal protein aggregation and deposition in the brain. Several
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22a34319420c19c1e82d20e24506c213
http://www.sciencedirect.com/science/article/pii/S0969996105002056
http://www.sciencedirect.com/science/article/pii/S0969996105002056
Autor:
Dan Goldowitz, Marcy MacDonald, Minka van Beuzekom, Nathan Goodman, Emma Hockly, Kim McCormick, Ray Truant, Bruce Kristal, Carl Johnson
Publikováno v:
Clinical Neuroscience Research. 3:197-217
We are developing a community website, called HDBase, to support basic scientific research on Huntington's Disease (HD). The core of the site is expert-reviewed scientific content consisting of curated bibliographies on topics of interest to HD resea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::44bf7b6bd5d14149370b720069e08d94
https://doi.org/10.1016/s1566-2772(03)00062-8
https://doi.org/10.1016/s1566-2772(03)00062-8
Autor:
Gillian P. Bates, Shabnam Ghazi-Noori, Donna L. Smith, Kirupa Sathasivam, Philip A. S. Lowden, Benjamin Woodman, Emma Hockly, Amarbirpal Mahal
Publikováno v:
Annals of Neurology. 54:186-196
Huntington's Disease (HD) is an inherited neurological disorder causing movement impairment, personality changes, dementia, and premature death, for which there is currently no effective therapy. The modified tetracycline antibiotic, minocycline, has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85605f68255d88d58d610b9ae1e2b85f
https://doi.org/10.1002/ana.10614
https://doi.org/10.1002/ana.10614
Autor:
Emma Hockly, Gillian P. Bates, Rachel Butler, Kirupa Sathasivam, Hilary Moffitt, Christian Landles, Ben Woodman, Michelle K. Lupton, Jamie Tse
Publikováno v:
Brain research bulletin. 72(2-3)
The identification of the Huntington's disease (HD) mutation as a CAG/polyglutamine repeat expansion enabled the generation of transgenic rodent models and gene-targeted mouse models of HD. Of these, mice that are transgenic for an N-terminal hunting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a2fd558c7e09d34db670f3a58f1a184
https://pubmed.ncbi.nlm.nih.gov/17352931
https://pubmed.ncbi.nlm.nih.gov/17352931
Autor:
Aida Abu-Baker, Tetsuo Ashizawa, Linda L. Bachinski, Albino Bacolla, Gillian P. Bates, John S. Belt, Dya Bezprozvanny, Sanjay Bidichandani, John J. Bissler, Alexis Brice, Kerri M. Carlson, CheunJu Chen, Thomas A. Cooper, Natividad Cortez-Apreza, John W. Day, Irene De Biase, Ruhee Dere, Didier Devys, Katherine A. Dick, Vincent Dion, Lisa M. Ellerby, Henry F. Epstein, Kenneth H. Fischbeck, Laurent Foiry, Rune R. Frants, Gwenn A. Garden, M´rio Gomes-Pereira, Geneviéve Gourdon, Paul J. Hagerman, Randi J Hagerman, Peter S. Harper, Vera I. Hashem, Michael R. Hayden, Micheal L. Hebert, Dominique Helmlinger, Emma Hockly, Susan E. Holmes, H.S. Hwang, Yoshio Ikeda, Kinya Ishikawa, George R. Jackson, Mariana Kekis, Beata Kosmider, Irina V. Kovtun, Ralf Krahe, Wlodzimierz J. Krzyzosiak, Albert R. La Spada, Jacquelynn E. Larson, Rachel Lau, Michael Leffak, Michelle R. Leonard, Yunfu Lin, Yuan Liu, Julien L. Marcadier, Jamie M. Margolis, Russell L. Margolis, Cynthia T. McMurray, Sergei M. Mirkin, Hidehiro Mizusawa, Darren G. Monckton, S. Erin Montgomery, Marek Napierala, David L. Nelson, Elizabeth O'Hearn, Ben A. Oostra, Harry T. Orr, George W. Padberg, Massimo Pandolfo, Gagan B. Panigrahi, Sharan Paul, Henry Paulson, Christopher E. Pearson, Olga Pletnikova, Vladimir N. Potaman, Mahmoud A. Pouladi, Rajendra Prasad, Héléne Puccio, Stefan M. Pulst, Malgorzata J. Pytlos, Laura P.W. Ranum, Lynn A. Raymond, Sita Reddy, Robert I. Richards, Christopher A. Ross, Guy Rouleau, Dobrila D. Rudnicki, Tzu-Kang Sang, Peggy E. Shelbourne, Michael J. Siciliano, Richard R. Sinden, Ram Singh, Krzysztof Sobczak, LesHe S. Son, Giovanni Stevanin, S. Strack, Maurice S. Swanson, J. Paul Taylor, Charles A. Thornton, Andrea Todd, Juan Troncoso, Ray Truant, Bjarne Udd, Karen Usdin, Silvere M. van der Maarel, Rene E.M.A. van Herpen, Caroline Vosch, Derick G. Wansink, Robert D. Wells, Ronald Wetzel, Bé Wieringa, Robert B. Wilson, Samuel H. Wilson, John H. Wilson, Marzena Wojciechowska
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bd4cd0ded2f3ce9679528ecf02b5ccd4
https://doi.org/10.1016/b978-012369462-1/50000-4
https://doi.org/10.1016/b978-012369462-1/50000-4
This chapter discusses molecular pathogenesis and therapeutic targets in Huntington's disease (HD). HD is an autosomal dominant, late onset neurodegenerative disease that is caused by a CAG/polyglutamine repeat expansion. Individuals with HD usually
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e22313339f610a12493d3d90ee15f4d
https://doi.org/10.1016/b978-012369462-1/50015-6
https://doi.org/10.1016/b978-012369462-1/50015-6
Autor:
Xiao-Jiang Li, James M. Olson, Caroline L. Benn, Jang Ho J. Cha, Shabnam Ghazi-Noori, He Li, Gillian P. Bates, Paul T. Sharpe, Syed M N N Faruque, Ben Woodman, Christian Landles, Shihua Li, Emma Hockly, Kirupa Sathasivam, Andrew D. Strand
Publikováno v:
Human molecular genetics. 14(20)
In postmortem Huntington's disease brains, mutant htt is present in both nuclear and cytoplasmic compartments. To dissect the impact of nuclear and extranuclear mutant htt on the initiation and progression of disease, we generated a series of transge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3414ba8a56ce5ba9abb9643c912aacf5
https://pubmed.ncbi.nlm.nih.gov/16183657
https://pubmed.ncbi.nlm.nih.gov/16183657
Autor:
J.L. Marsh, Shabnam Ghazi-Noori, Gillian P. Bates, Kirupa Sathasivam, Victoria M. Richon, Leslie M. Thompson, Xianbo Zhou, Donna L. Smith, Amarbirpal Mahal, Cathryn M. Lewis, Paul A. Marks, Emma Hockly, Philip A. S. Lowden, Joan S. Steffan, E. Rosa, Benjamin Woodman
Huntington's disease (HD) is an inherited, progressive neurological disorder that is caused by a CAG/polyglutamine repeat expansion and for which there is no effective therapy. Recent evidence indicates that transcriptional dysregulation may contribu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5925ffc4d9dfa1f68b14994e20537c5
https://europepmc.org/articles/PMC149955/
https://europepmc.org/articles/PMC149955/