Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Emma Hickman"'
Publikováno v:
SLAS Discovery. 21:769-785
Evidence of adaptive immune responses in the prevention of cancer has been accumulating for decades. Spontaneous T-cell responses occur in multiple indications, bringing the study of de novo expressed cancer antigens to the fore and highlighting thei
Autor:
Francesco Carbone, Stephanie Littlewood, Adriana Gambardella, Rebekka Krumbach, Gemma Corr, Laura C. Collins, Emma Hickman
Publikováno v:
Cancer Research. 78:209-209
Gene expression data from whole tumor samples represent averaged expression of all the tumor cells, stromal cells and normal adjacent cells present in a given sample. Identification of colon tumor-specific genes may be hampered by contamination from
Publikováno v:
British Journal of Pharmacology. 168:1946-1960
Background and Purpose Our recent studies on human airway serous-like Calu-3 cells showed that cAMP agonists stimulated a HCO3− rich secretion containing up to 80 mM HCO3−. This alkaline secretion relied on a coordinated switch in the activity of
Autor:
Emma Hickman, Luise U. Weigand, Debbie Baker, Linda Hibbert, Annelise Vuidepot, Namir J. Hassan, Zoe Donnellan, Samantha Paston, Louise Conlon, Giovanna Bossi, Joseph Dukes, Ruth Simmons, Ruth Ryan, Caroline Boudousquie, Alex Powlesland, Vanessa L. Clark, Bent K. Jakobsen, Kathy Hale
Publikováno v:
Journal for Immunotherapy of Cancer
Meeting abstracts Malignant cells may be recognised by T cells binding cell surface Class I HLA (Human Leukocyte Antigen)-peptide complexes presenting disease-associated epitopes. Many cancer patients have been shown to generate CD8 cytotoxic T cell
Autor:
Michael A. Gray, László Tiszlavicz, Emma Hickman, Péter Hegyi, James P. Garnett, Alan W. Cuthbert, Rachel Burrows, Peying Fong
Publikováno v:
Journal of Biological Chemistry. 286:41069-41082
In most HCO(3)(-)-secreting epithelial tissues, SLC26 Cl(-)/HCO(3)(-) transporters work in concert with the cystic fibrosis transmembrane conductance regulator (CFTR) to regulate the magnitude and composition of the secreted fluid, a process that is
Autor:
Marine C C Raman, Pierre J Rizkallah, Ruth Simmons, Zoe Donnellan, Joseph Dukes, Giovanna Bossi, Gabrielle S Le Provost, Penio Todorov, Emma Baston, Emma Hickman, Tara Mahon, Namir Hassan, Annelise Vuidepot, Malkit Sami, David K Cole, Bent K. Jakobsen
Publikováno v:
Scientific Reports
Natural T-cell responses generally lack the potency to eradicate cancer. Enhanced affinity T-cell receptors (TCRs) provide an ideal approach to target cancer cells, with emerging clinical data showing significant promise. Nevertheless, the risk of of
Autor:
Laszlo Radvanyi, Achim A. Jungbluth, Stanley R Frankel, Adrian Bot, Zelig Eshhar, Yoav Peretz, Kai W. Wucherpfennig, Paul F Robbins, Emma Hickman, Carlos A. Ramos, Richard A. Morgan, Joanna E Brewer
Publikováno v:
Journal for Immunotherapy of Cancer
Investigators from academia and industry gathered on August 14, 2014, in Boston at the Inaugural ImVacS conference entitled “Target Discovery for T Cell Therapy: Next Step to Advance Immunotherapies”. Novel targets, discovery strategies and enabl
Autor:
Luise U. Weigand, Samantha Paston, Linda Hibbert, Ruth K. Ryan, Debbie E. Baker, Ruth A. Simmons, Jane V. Harper, Joseph D. Dukes, Giovanna Bossi, Francis Grand, Emma Hickman, Alex Powlesland, Annelise Vuidepot, Namir J. Hassan, Bent K. Jakobsen
Publikováno v:
Cancer Research. 74:2805-2805
Malignant cells may be recognized by T cells binding cell surface Class I HLA-peptide complexes presenting disease-associated epitopes. Many cancer patients generate CD8 cytotoxic T cell responses to tumor-associated antigens, however due to the low
Publikováno v:
Cellular signalling. 19(12)
Use of mice in which individual PI3K isoforms have been deleted or mutated by gene targeting, has determined that PI3Kgamma provides a key migratory signal for T lymphocyte migration. Since PI3Kgamma can be a dispensable signal for directional migrat
Autor:
Christopher Corrigan, Joanne McDonald, David J. Cousins, Zahid Sattar, Zoe Urry, David F. Richards, Catherine M. Hawrylowicz, Emma Hickman, Emmanuel Xystrakis, Zarin Brown
Publikováno v:
The Journal of clinical investigation. 119(2)
Signaling through the TLR family of molecular pattern recognition receptors has been implicated in the induction of innate and adaptive immune responses. A role for TLR signaling in the maintenance and/or regulation of Treg function has been proposed