Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Emma Heart"'
Autor:
Marie-Line Peyot, Joshua P Gray, Julien Lamontagne, Peter J S Smith, George G Holz, S R Murthy Madiraju, Marc Prentki, Emma Heart
Publikováno v:
PLoS ONE, Vol 4, Iss 7, p e6221 (2009)
BACKGROUND:Glucagon like peptide-1 (GLP-1) and its analogue exendin-4 (Ex-4) enhance glucose stimulated insulin secretion (GSIS) and activate various signaling pathways in pancreatic beta-cells, in particular cAMP, Ca(2+) and protein kinase-B (PKB/Ak
Externí odkaz:
https://doaj.org/article/7d396a0b850a4ad5aa357832404999c2
Autor:
Emma Heart, Joshua P. Gray
Publikováno v:
Toxicology Mechanisms and Methods. 20:167-174
Insulin secretion from pancreatic beta cells is a process dependent on metabolism. While oxidative stress is a well-known inducer of beta cell toxicity and impairs insulin secretion, recent studies suggest that low levels of metabolically-derived rea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a20ca90ab52edf38941be4bfbd08c2b1
https://doi.org/10.3109/15376511003695181
https://doi.org/10.3109/15376511003695181
Autor:
Emma Heart, Chin K. Sung
Publikováno v:
Journal of Cellular Biochemistry. 88:719-731
In insulin-sensitive 3T3-L1 adipocytes, selenium stimulates glucose transport and antilipolysis and these actions of selenium, like insulin actions, are sensitive to wortmanin, an inhibitor of phosphatidylinositol-3-kinase (PI3K). Selenium stimulates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cac69e59af7c07ff31d616b9650a8f5
https://doi.org/10.1002/jcb.10395
https://doi.org/10.1002/jcb.10395
Publikováno v:
American Journal of Physiology-Cell Physiology. 294:C4-C6
the hormonal activation of cAMP production in pancreatic β-cells is accompanied by an increase of cytosolic [cAMP] that can be measured in real time through the use of a cAMP sensor (Epac1-camps) that exhibits a decrease of fluorescence resonance en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14982f364a36c6b3ca0d4ee3e5cd8a93
https://doi.org/10.1152/ajpcell.00522.2007
https://doi.org/10.1152/ajpcell.00522.2007
Publikováno v:
American journal of physiology. Endocrinology and metabolism. 303(2)
NADPH is an important component of the antioxidant defense system and a proposed mediator in glucose-stimulated insulin secretion (GSIS) from pancreatic β-cells. An increase in the NADPH/NADP+ ratio has been reported to occur within minutes followin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd9a19e004c45a78271030929028ce7b
https://pubmed.ncbi.nlm.nih.gov/22550069
https://pubmed.ncbi.nlm.nih.gov/22550069
Pancreatic β-cells release insulin in response to elevation of glucose from basal (4–7 mM) to stimulatory (8–16 mM) levels. Metabolism of glucose by the β-cell results in the production of low levels of reactive oxygen intermediates (ROI), such
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6463ad7b077cd70d96d1c2c4f01f4223
https://eprints.soton.ac.uk/203567/
https://eprints.soton.ac.uk/203567/
Publikováno v:
American journal of physiology. Endocrinology and metabolism. 301(1)
Plasma membrane electron transport (PMET), a cytosolic/plasma membrane analog of mitochondrial electron transport, is a ubiquitous system of cytosolic and plasma membrane oxidoreductases that oxidizes cytosolic NADH and NADPH and passes electrons to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ffc6aab01c75968f6432a948201e0ce
https://pubmed.ncbi.nlm.nih.gov/21505151
https://pubmed.ncbi.nlm.nih.gov/21505151
Autor:
Joshua P. Gray, Marc Prentki, Emma Heart, George G. Holz, Peter K. Smith, S.R. Murthy Madiraju, Marie-Line Peyot, Julien Lamontagne
Publikováno v:
PLoS ONE
PLoS ONE, Vol 4, Iss 7, p e6221 (2009)
PLoS ONE, Vol 4, Iss 7, p e6221 (2009)
Background: glucagon like peptide-1 (GLP-1) and its analogue exendin-4 (Ex-4) enhance glucose stimulated insulin secretion (GSIS) and activate various signaling pathways in pancreatic beta-cells, in particular cAMP, Ca(2+) and protein kinase-B (PKB/A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d934c6ea0bba772d962df9440253198
https://eprints.soton.ac.uk/190273/
https://eprints.soton.ac.uk/190273/
Autor:
Joshua P. Gray, Emma Heart, Leon P. Collis, Gary W. Cline, Rebecca L. Pongratz, Peter K. Smith
Pyruvate cycling has been implicated in glucose-stimulated insulin secretion (GSIS) from pancreatic β-cells. The operation of some pyruvate cycling pathways is proposed to necessitate malate export from the mitochondria and NADP+-dependent decarboxy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2b82dbd8de7df0d53574eb200ef51e4
https://europepmc.org/articles/PMC2692397/
https://europepmc.org/articles/PMC2692397/
Publikováno v:
IET nanobiotechnology. 2(2)
Dielectrophoretic forces, generated by radio-frequency voltages applied to micromachined, transparent, indium tin oxide electrodes, have been used to condense suspensions of insulinoma cells (BETA-TC-6 and INS-1) into a 10 x 10 array of three-dimensi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82acbe50fe3f6660eaaee928708fd63a
https://pubmed.ncbi.nlm.nih.gov/18500910
https://pubmed.ncbi.nlm.nih.gov/18500910