Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Emma H Wilson"'
Autor:
Joshua B Radke, Danielle Worth, David Hong, Sherri Huang, William J Sullivan, Emma H Wilson, Michael W White
Publikováno v:
PLoS Pathogens, Vol 14, Iss 5, p e1007035 (2018)
Tachyzoite to bradyzoite development in Toxoplasma is marked by major changes in gene expression resulting in a parasite that expresses a new repertoire of surface antigens hidden inside a modified parasitophorous vacuole called the tissue cyst. The
Externí odkaz:
https://doaj.org/article/ace1116a0b0e43b2addd43ffc479cd52
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-16 (2024)
Abstract Background Infection with the protozoan parasite Toxoplasma gondii leads to the formation of lifelong cysts in neurons that can have devastating consequences in the immunocompromised. In the immunocompetent individual, anti-parasitic effecto
Externí odkaz:
https://doaj.org/article/696b781676844406b19d80c1e4c1c4ad
Autor:
Clément N David, Elma S Frias, Jenny I Szu, Philip A Vieira, Jacqueline A Hubbard, Jonathan Lovelace, Marena Michael, Danielle Worth, Kathryn E McGovern, Iryna M Ethell, B Glenn Stanley, Edward Korzus, Todd A Fiacco, Devin K Binder, Emma H Wilson
Publikováno v:
PLoS Pathogens, Vol 12, Iss 6, p e1005643 (2016)
The immune privileged nature of the CNS can make it vulnerable to chronic and latent infections. Little is known about the effects of lifelong brain infections, and thus inflammation, on the neurological health of the host. Toxoplasma gondii is a par
Externí odkaz:
https://doaj.org/article/594ba3aa269948fd9ac314751eab2c99
Protocol for the longitudinal study of neuroinflammation and reactive astrocytes in Lcn2CreERT2 mice
Autor:
Teresa Ubina, William Agnew-Svoboda, Zoe A. Figueroa, Emma H. Wilson, Todd A. Fiacco, Martin M. Riccomagno
Publikováno v:
STAR Protocols, Vol 5, Iss 4, Pp 103322- (2024)
Summary: During brain disease, astrocytes can reprogram into a reactive state that alters many of their functions. Here, we present a protocol for studying neuroinflammation and reactive astrogliosis in mice using lipopolysaccharide (LPS) from E. col
Externí odkaz:
https://doaj.org/article/d47f5e331948471bb68096be3e820e12
Autor:
J Philip Nance, Kevin M Vannella, Danielle Worth, Clément David, David Carter, Shahani Noor, Cedric Hubeau, Lori Fitz, Thomas E Lane, Thomas A Wynn, Emma H Wilson
Publikováno v:
PLoS Pathogens, Vol 8, Iss 11, p e1002990 (2012)
Chronic infections represent a continuous battle between the host's immune system and pathogen replication. Many protozoan parasites have evolved a cyst lifecycle stage that provides it with increased protection from environmental degradation as well
Externí odkaz:
https://doaj.org/article/8a5cbad8be0c4e56abe471ec055b1d30
Publikováno v:
ASN Neuro, Vol 3 (2010)
Chronic infection with the intracellular protozoan parasite Toxoplasma gondii leads to tissue remodelling in the brain and a continuous requirement for peripheral leucocyte migration within the CNS (central nervous system). In the present study, we i
Externí odkaz:
https://doaj.org/article/0f8e727db2834c32bd7b1b513ede523e
Autor:
Beena John, Tajie H Harris, Elia D Tait, Emma H Wilson, Beth Gregg, Lai Guan Ng, Paulus Mrass, David S Roos, Florence Dzierszinski, Wolfgang Weninger, Christopher A Hunter
Publikováno v:
PLoS Pathogens, Vol 5, Iss 7, p e1000505 (2009)
To better understand the initiation of CD8(+) T cell responses during infection, the primary response to the intracellular parasite Toxoplasma gondii was characterized using 2-photon microscopy combined with an experimental system that allowed visual
Externí odkaz:
https://doaj.org/article/779855c1113d44ffa2f2cba1b1e360d0
Autor:
Edward A. Vizcarra, Amber L. Goerner, Arzu Ulu, David D. Hong, Kristina V. Bergersen, Michael A. Talavera, Karine Le Roch, Emma H. Wilson, Michael W. White
Publikováno v:
mBio, Vol 14, Iss 5 (2023)
ABSTRACT The recrudescence of Toxoplasma cysts is the cause of clinical disease in the immunocompromised. Although Toxoplasma has been a useful parasite model for decades because it is relatively easy to genetically modify and culture, attempts to ge
Externí odkaz:
https://doaj.org/article/14837641a9d345ea9a306eb21cc8aa02
Infection with the protozoan parasiteToxoplasma gondiileads to the formation of lifelong cysts in neurons of the brain that can have devastating consequences in the immunocompromised. However, despite the establishment of a chronic inflammatory state
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::afbd882e1ab887e42a5d26587d5cd255
https://doi.org/10.1101/2022.08.12.503720
https://doi.org/10.1101/2022.08.12.503720
Autor:
David D. Hong, Krista Brooks, Amber L. Goerner, Edward A. Vizcarra, Luiza N. Loges, Emma H. Wilson, Michael W. White
Current approaches to find therapeutic solutions to treat and prevent reactivation of toxoplasmosis have suffered from limited accessibility to the relevant Toxoplasma stages and a lack of accurate in vitro developmental models. The loss of developme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c3f77870f310d40942193bd1488880ac
https://doi.org/10.1101/2022.07.21.500998
https://doi.org/10.1101/2022.07.21.500998