Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Emma Gudgin"'
Autor:
José Guilherme de Almeida, Emma Gudgin, Martin Besser, William G. Dunn, Jonathan Cooper, Torsten Haferlach, George S. Vassiliou, Moritz Gerstung
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Many hematological diseases are characterized by altered abundance and morphology of blood cells and their progenitors. Myelodysplastic syndromes (MDS), for example, are a group of blood cancers characterised by cytopenias, dysplasia of hema
Externí odkaz:
https://doaj.org/article/899f50b6b94d4f4393095f6debfb084d
Autor:
José Guilherme de Almeida, Emma Gudgin, Martin Besser, William G. Dunn, Jonathan Cooper, Torsten Haferlach, George S. Vassiliou, Moritz Gerstung
Many hematological diseases are characterized by altered abundance and morphology of blood cells and their progenitors. Myelodysplastic syndromes (MDS), for example, are a type of blood cancer manifesting via a range of cytopenias and dysplastic chan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a82f06588179ce6f0471d3cdd068b53
https://doi.org/10.1101/2022.04.19.22273757
https://doi.org/10.1101/2022.04.19.22273757
Publikováno v:
Blood Coagulation & Fibrinolysis. 30:426-428
We present two cases where argatroban was successfully used in patients with acute thrombosis requiring anticoagulant treatment where heparin resistance with unfractionated heparin had been encountered. The first case was a woman with abdominal arter
Autor:
David Gilligan, Stephen D. Preston, Martin Besser, Paul D. Hayes, Anthony W Martinelli, Matthew Waite, Adam Peryt, Emily Symington, Robert C. Rintoul, Emma Gudgin, Patrick A. Coughlin
Publikováno v:
Clinical Case Reports
Key Clinical Message We report a case of lung adenocarcinoma‐associated hypercoagulability leading to venous limb gangrene, managed successfully with argatroban and then dabigatran. Use of idarucizumab permitted diagnostic investigations, leading t
Autor:
Huan Cao, John Elvin, Emma Gudgin, Andreas Neerincx, Brian J. P. Huntly, John Trowsdale, Bernard de Bono, Clare Pridans, Mark A. Vickers, Ursula Lakner, Catherine Huntington, Alexander D. Barrow
Publikováno v:
British journal of haematologyReferences. 193(5)
Sialic acid-binding immunoglobulin-like lectin (Siglec)-15 has recently been identified as a critical tumour checkpoint, augmenting the expression and function of programmed death-ligand 1. We raised a monoclonal antibody, A9E8, specific for Siglec-1
Autor:
Steve Knapper, Fiona Clark, Emma Gudgin, Rachel Fletcher, Aimee Jackson, Srinivasan Narayanan, Christina Yap, Charlotte K. Brierley, Adam J. Mead, Dragana Milojkovic, Charlotte Gaskell, Jennifer Byrne, Claire N. Harrison, Tim C. P. Somervaille, Mark Drummond, David G. Bowen
Publikováno v:
Blood. 136:2-3
Background Treatments for 'accelerated phase' MPNs (MPN-AP, 10-19% blasts)/post-MPN AML (MPN-BP, ≥20% blasts) are limited. Most patients are precluded from potentially curative haematopoietic stem cell transplantation (HSCT). For HSCT ineligible pa
Publikováno v:
Encyclopedia of Pathology ISBN: 9783319288451
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::077e437586301e251a3809e2fcb01da3
https://doi.org/10.1007/978-3-319-95309-0_3816
https://doi.org/10.1007/978-3-319-95309-0_3816
Autor:
Lizz F. Grimwade, Graham Bottley, George S. Vassiliou, Brian J. P. Huntly, Michael A. Scott, Emma Gudgin, Wendy N. Erber, David Bloxham
Publikováno v:
Cytometry Part A. :896-900
Mutations within the nucleophosmin NPM1 gene occur in approximately one-third of cases of acute myeloid leukemia (AML). These mutations result in cytoplasmic accumulation of the mutant NPM protein. NPM1 mutations are currently detected by molecular m
Autor:
Wendy N. Erber, Anthony R. Green, Emma Gudgin, Brian J. P. Huntly, Shubha Anand, Philip A. Beer, Anthony J. Bench, Frances Stedham, Christina A. Ortmann
Publikováno v:
Blood. 118:177-181
The JAK2 V617F mutation is present in the majority of patients with a myeloproliferative neoplasm (MPN) and is sufficient to recapitulate an MPN in murine models. However, the consequences of JAK2 mutations for myeloid differentiation are poorly unde
Autor:
Emma J. Roberts, Peter Ernest Soden, Ruud Delwel, Dave Lugo, Brian J. P. Huntly, Samuel Robson, Olivier Mirguet, Chun-wa Chung, Soren Beinke, Rab K. Prinjha, Mikhail M. Savitski, Trevor D. Chapman, Carola Huthmacher, Emma Gudgin, Alan Kenneth Burnett, Gerard Drewes, Mark A. Dawson, Tony Kouzarides, Wai-In Chan, Konstanze Doehner, Kevin Lee, Phillip Jeffrey, Carsten Hopf, Antje Dittmann, Marcus Bantscheff, George Giotopoulos, Kurt R. Auger
Publikováno v:
Nature, 478(7370), 529-533. Nature Publishing Group
Recurrent chromosomal translocations involving the mixed lineage leukaemia (MLL) gene initiate aggressive forms of leukaemia, which are often refractory to conventional therapies(1). Many MLL-fusion partners are members of the super elongation comple