Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Emma Graffice"'
Autor:
Bruce A Berkowitz, Robert H Podolsky, Karen Lins Childers, Aicha Saadane, Timothy S Kern, Robin Roberts, Hailey Olds, Joydip Joy, Collin Richards, Tilman Rosales, Michael Schneider, Brennan Schilling, Arthur Orchanian, Emma Graffice, Kenan Sinan, Haohua Qian, Lamis Harp
Publikováno v:
PLoS ONE, Vol 16, Iss 3, p e0245161 (2021)
PurposeThe phosphodiesterase inhibitor sildenafil is a promising treatment for neurodegenerative disease, but it can cause oxidative stress in photoreceptors ex vivo and degrade visual performance in humans. Here, we test the hypotheses that in wildt
Externí odkaz:
https://doaj.org/article/b014038296a542b78b217a813892662a
Autor:
Yimin Shen, Alana C. Conti, Ali M Berri, Kelly E. Bosse, Robin Roberts, Bruce A. Berkowitz, Kenan Sinan, Alexander Gow, Brandy L. Schneider, Karen Lins Childers, Waleed Eliwat, Scott C Lloyd, Robert H. Podolsky, Emma Graffice
Publikováno v:
GeroScience
Age-related impairments in spatial learning and memory often precede non-familial neurodegenerative disease. Ex vivo studies suggest that physiologic age-related oxidative stress in hippocampus area CA1 may contribute to prodromal spatial disorientat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78fc74aa7a4c486891ad4e35757b98e2
https://doi.org/10.1007/s11357-020-00162-8
https://doi.org/10.1007/s11357-020-00162-8
Autor:
Brennan Schilling, Lamis Harp, Haohua Qian, Joydip Joy, Michael Schneider, Robert H. Podolsky, Kenan Sinan, Timothy S. Kern, Arthur Orchanian, Emma Graffice, Tilman Rosales, Robin Roberts, Karen Lins Childers, Bruce A. Berkowitz, Collin Richards, Aicha Saadane, Hailey Olds
Publikováno v:
PLoS ONE, Vol 16, Iss 3, p e0245161 (2021)
PLoS ONE
PLoS ONE
Purpose The phosphodiesterase inhibitor sildenafil is a promising treatment for neurodegenerative disease, but it can cause oxidative stress in photoreceptors ex vivo and degrade visual performance in humans. Here, we test the hypotheses that in wild
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3f78e9958cdf76f2fa56b3fb691987a
https://doaj.org/article/b014038296a542b78b217a813892662a
https://doaj.org/article/b014038296a542b78b217a813892662a
Autor:
Michael Schneider, Robert H. Podolsky, Robin Roberts, Kenan Sinan, Thomas G. Cotter, Karen Lins Childers, Shasha Gao, Haohua Qian, Ali M Berri, Sarah L. Roche, Bruce A. Berkowitz, Emma Graffice, Lamis Harp
Publikováno v:
Investigative Ophthalmology & Visual Science
Purpose The purpose of this study was to test the hypothesis that anti-oxidant and / or anti-inflammation drugs that suppress rod death in cyclic light-reared Pde6brd10 mice are also effective in dark-reared Pde6brd10 mice. Methods In untreated dark-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a993eb6c8c6c877be9c00c398147f7bf
https://pubmed.ncbi.nlm.nih.gov/33156341
https://pubmed.ncbi.nlm.nih.gov/33156341
Autor:
Andrew D. Winters, Roberto Romero, Emma Graffice, Nardhy Gomez-Lopez, Eunjung Jung, Tomi Kanninen, Kevin R. Theis
Publikováno v:
J Reprod Immunol
Microbial invasion of the amniotic cavity (MIAC) leading to infection is strongly associated with adverse pregnancy and neonatal outcomes. Limitations of current diagnostic assays to detect MIAC rapidly and accurately have hindered the ability of obs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e83395064fdf13f0563596b315825923
https://doi.org/10.1016/j.jri.2021.103460
https://doi.org/10.1016/j.jri.2021.103460
Autor:
Ali M Berri, Robin Roberts, Fatema Shafie-Khorassani, Emma Graffice, Bruce A. Berkowitz, Robert H. Podolsky, Kristin Dernay
Publikováno v:
Investigative Ophthalmology & Visual Science
Purpose In cyclic light-reared Pde6brd10 mice, rod cell oxidative stress contributes to the degenerative phenotype. Dark rearing Pde6brd10 mice slows but does not prevent atrophy. This suggests that outer retinal oxidative stress occurs in Pde6brd10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d88770670d5ca7cfc5fd5c58b6dfcdbe
http://europepmc.org/articles/PMC5868999
http://europepmc.org/articles/PMC5868999
Autor:
Benjamin Farrell, Robert H. Podolsky, Emma Graffice, Bruce A. Berkowitz, Christopher Trepanier, Kristin Dernay, Hojun Lee, Ali M Berri, Fatema Shafie-Khorassani, Robin Roberts, Timothy S. Kern
Publikováno v:
Investigative Ophthalmology & Visual Science
Investigative ophthalmology & visual science, vol 59, iss 7
Investigative ophthalmology & visual science, vol 59, iss 7
Purpose New perspectives are needed to understand decades of contradictory reports on the neuroprotective effects of the Cav1.2 L-type calcium channel blocker d-cis-diltiazem in retinitis pigmentosa (RP) models. Here, we address, in vivo, the followi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67a94f8d330d20bafca6bab8c942f042
http://europepmc.org/articles/PMC5995482
http://europepmc.org/articles/PMC5995482
Autor:
Bruce A. Berkowitz, Emma Graffice, Robin Roberts, Michael Schneider, Robert H. Podolsky, Ali M Berri, Lamis Harp, Karen Lins Childers, Kenan Sinan
Publikováno v:
Investigative Ophthalmology & Visual Science
Purpose To test the hypothesis that acutely correcting a sustained presence of outer retina free radicals measured in vivo in 24-month-old mice corrects their reduced visual performance. Methods Male C57BL/6J mice two and 24 months old were noninvasi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f21a2509d0398767ec4be40841233f1
https://doi.org/10.1167/iovs.62.6.24
https://doi.org/10.1167/iovs.62.6.24