Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Emma E. Fairweather"'
Autor:
Alba Maiques-Diaz, Gary J. Spencer, James T. Lynch, Filippo Ciceri, Emma L. Williams, Fabio M.R. Amaral, Daniel H. Wiseman, William J. Harris, Yaoyong Li, Sudhakar Sahoo, James R. Hitchin, Daniel P. Mould, Emma E. Fairweather, Bohdan Waszkowycz, Allan M. Jordan, Duncan L. Smith, Tim C.P. Somervaille
Publikováno v:
Cell Reports, Vol 22, Iss 13, Pp 3641-3659 (2018)
Summary: Pharmacologic inhibition of LSD1 promotes blast cell differentiation in acute myeloid leukemia (AML) with MLL translocations. The assumption has been that differentiation is induced through blockade of LSD1’s histone demethylase activity.
Externí odkaz:
https://doaj.org/article/62c57f81e288426abeec246fcdba9441
Autor:
Aarya Venkat, Grace Watterson, Dominic P Byrne, Brady O'Boyle, Safal Shrestha, Nathan Gravel, Emma E Fairweather, Leonard A Daly, Claire Bunn, Wayland Yeung, Ishan Aggarwal, Samiksha Katiyar, Claire E Eyers, Patrick A Eyers, Natarajan Kannan
Publikováno v:
eLife, Vol 12 (2023)
Catalytic signaling outputs of protein kinases are dynamically regulated by an array of structural mechanisms, including allosteric interactions mediated by intrinsically disordered segments flanking the conserved catalytic domain. The doublecortin-l
Externí odkaz:
https://doaj.org/article/f4f43ea236f54c43b1f0fe6ed2bbb536
Autor:
Peter A. Jones, Ashley K. Wiseman, Helai P. Mohammad, Christopher S. Kershaw, Bryan W. King, Ian D. Waddell, Thau F. Ho, Stephen B. Baylin, Morris Muliaditan, Marcus Bantscheff, Elisabeth A. Minthorn, Thilo Werner, Alan P. Graves, Wendy A. Kellner, Phil Chapman, Mehul Patel, Anthony J. Jurewicz, Allan M. Jordan, Emma E. Fairweather, Rab K. Prinjha, Nino Campobasso, Anna Rutkowska, H. Christian Eberl, Ryan G. Kruger, Charles F. McHugh, Michael T. McCabe, Kristin M. Goldberg, Jon Paul Jaworski, Christopher L. Carpenter, Michael Steidel, Stuart Paul Romeril, Dirk A. Heerding, Lourdes Rueda, David T. Fosbenner, Amy N. Taylor, Jacques Briand, Shawn W. Foley, Arthur Groy, Andrew B. Benowitz, Xiaodong Cheng, Donald J. Ogilvie, Paola Grandi, Cunyu Zhang, Mei Li, Sarath Pathuri, Aidan G. Gilmartin, Christian S. Sherk, Juan I. Luengo, Mark Cockerill, Ali Raoof, Alexandra Stowell, Kathryn Keenan, Melissa B. Pappalardi, Makda Mebrahtu, Kristen Wong, Xing Zhang, Jessica L. Handler, Roger J. Butlin, John R. Horton, Susan Merrihew, Charlotte Burt, Dean E. McNulty
Publikováno v:
Nature Cancer. 2:1002-1017
DNA methylation, a key epigenetic driver of transcriptional silencing, is universally dysregulated in cancer. Reversal of DNA methylation by hypomethylating agents, such as the cytidine analogs decitabine or azacytidine, has demonstrated clinical ben
Autor:
Julie A. Tucker, Ben Acton, Ian D. Waddell, Alexandra Stowell, Nicola Hamilton, Niall M. Hamilton, Kate M. Smith, Stuart Donald Jones, James R. Hitchin, Bohdan Waszkowycz, Alison E. McGonagle, Dominic I. James, Allan M. Jordan, Daniel P. Mould, Clifford David Jones, Colin Hutton, Helen F. Small, Emma E. Fairweather, Donald J. Ogilvie, Louise A. Griffiths
Publikováno v:
Waszkowycz, B, Smith, K, Mcgonagle, A, Jordan, A, Acton, B, Fairweather, E, Griffiths, L, Hamilton, N M, Hamilton, N, Hitchin, J R, Hutton, C, James, D I, Jones, C D, Jones, S, Mould, D, Small, H F, Stowell, A, Tucker, J, Waddell, I & Ogilvie, D J 2018, ' Cell-active Small Molecule Inhibitors of the DNA-damage Repair Enzyme Poly(ADP-ribose) Glycohydrolase (PARG): Discovery and Optimization of Orally Bioavailable Quinazolinedione Sulfonamides ', Journal of Medicinal Chemistry, vol. 61, no. 23, pp. 10767–10792 . https://doi.org/10.1021/acs.jmedchem.8b01407
DNA damage repair enzymes are promising targets in the development of new therapeutic agents for a wide range of cancers and potentially other diseases. The enzyme poly(ADP-ribose) glycohydrolase (PARG) plays a pivotal role in the regulation of DNA r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e713bd6a754c7026f2f63ab3b3df4e2
https://doi.org/10.1021/acs.jmedchem.8b01407
https://doi.org/10.1021/acs.jmedchem.8b01407
Autor:
Emma E. Fairweather, R.S. Williams, Matthew J. Schellenberg, Ian D. Waddell, J Little, Percy P. Tumbale, Mandy Watson, Geoffrey A. Mueller, Robert E. London, Juno M. Krahn
Publikováno v:
The EMBO Journal
The failure of DNA ligases to complete their catalytic reactions generates cytotoxic adenylated DNA strand breaks. The APTX RNA‐DNA deadenylase protects genome integrity and corrects abortive DNA ligation arising during ribonucleotide excision repa
Autor:
James R. Hitchin, Nicola Hamilton, Graeme J. Thomson, Amanda J. Lyons, Allan M. Jordan, Donald J. Ogilvie, Niall M. Hamilton, Dominic I. James, Ian D. Waddell, Helen F. Small, Emma E. Fairweather, Martin J Dawson, Stuart Donald Jones
Publikováno v:
Journal of Medicinal Chemistry. 55:4431-4445
Novel derivatives of the steroid DHEA 1, a known uncompetitive inhibitor of G6PD, were designed, synthesized, and tested for their ability to inhibit this dehydrogenase enzyme. Several compounds with approximately 10-fold improved potency in an enzym
Autor:
Mark Cockerill, Melissa B. Pappalardi, Mehul Patel, Donald gilvie, Christopher L. Carpenter, Emma E. Fairweather, Juan I. Luengo, Alexandra Stowell, Graeme J. Thomson, Ali Raoof, Charlotte Burt, Ian D. Waddell, Allan M. Jordan, Ryan G. Kruger
Publikováno v:
Cancer Research. 78:LB-068
DNA Methyltransferases (or DNMTs) play an important role in genomic integrity. The DNMT family of enzymes catalyse the transfer of methyl groups to specific CpG structures on DNA, with DNMT1 acting as a maintenance methyltransferase and DNMT3a and 3b
Autor:
Kerry Shea, Stephen T. Durant, Louise A. Griffiths, Emma E. Fairweather, Kay Eckersley, Dominic I. James, Ian D. Waddell, Donald J. Ogilvie, Paul P. Kelly, Mark J. O'Connor, Nicola Hamilton
Publikováno v:
James, D I, Durant, S, Eckersley, K, Fairweather, E, Griffiths, L A, Hamilton, N, Kelly, P, O'Connor, M, Shea, K, Waddell, I D & Ogilvie, D J 2016, ' An assay to measure poly(ADP ribose) glycohydrolase (PARG) activity in cells ', F1000Research, vol. 5, no. 736, pp. 736 . https://doi.org/10.12688/f1000research.8463.2
F1000Research
F1000Research
After a DNA damage signal multiple polymers of ADP ribose attached to poly(ADP) ribose (PAR) polymerases (PARPs) are broken down by the enzyme poly(ADP) ribose glycohydrolase (PARG). Inhibition of PARG leads to a failure of DNA repair and small molec
Autor:
Donald J. Ogilvie, Allan M. Jordan, Gemma Hopkins, Dominic I. James, Alexandra Stowell, L. Griffiths, Kate M. Smith, Ian D. Waddell, Emma E. Fairweather, Alison E. McGonagle
Publikováno v:
European Journal of Cancer. 61:S126
Autor:
Stuart Donald Jones, Bohdan Waszkowycz, Daniel P. Mould, Nicola Hamilton, Helen F. Small, Sam Fritzl, Alison E. McGonagle, Emma E. Fairweather, Dominic I. James, Alexandra Stowell, Ben Acton, Allan M. Jordan, Niall M. Hamilton, Donald J. Ogilvie, Ian D. Waddell, Kate M. Smith, Sarah Holt, James Hitchen, Colin Hutton
Publikováno v:
Molecular Cancer Therapeutics. 14:C39-C39
Poly(ADP-ribose) glycohydrolase (PARG) is the only enzyme known to catalyse hydrolysis of the O-glycosidic linkages of ADP-ribose polymers, thereby reversing the effects of poly(ADP-ribose) polymerases (PARPs). PARG depletion, using RNAi, results in