EWS-FLI1 and Activator Protein-1 (AP-1) Reciprocally Regulate Extracellular-Matrix Proteins in Ewing sarcoma Cells

Autor: Emma E. Croushore, Christopher S. Stipp, David J. Gordon

Publikováno v: International Journal of Molecular Sciences, Vol 25, Iss 16, p 8595 (2024)

Ribonucleotide reductase (RNR) is the rate-limiting enzyme in the synthesis of deoxyribonucleotides and the target of multiple chemotherapy drugs, including gemcitabine. We previously identified that inhibition of RNR in Ewing sarcoma tumors upregula

Externí odkaz: https://doaj.org/article/44f2127aeecf4e698c2b3617c6715ff1

Olfactory dysfunction in the 3xTg-AD model of Alzheimer’s disease

Autor: Sam E. Houle, Rachel A. Schendzielos, Harold J. Grau, Darlene A. Mitrano, Emma E. Croushore, Patrick Pearce, Blakely K. Lockhart, James W. Bogenpohl, Lisa Smith Webb, Ethan M. Dymond, Benjamin C. Genovese, Ricardo M. Quintanilla

Publikováno v: IBRO Neuroscience Reports
IBRO Neuroscience Reports, Vol 10, Iss, Pp 51-61 (2021)

Alzheimer’s disease (AD) is an incurable neurodegenerative disease in which the risk of development increases with age. People with AD are plagued with deficits in their cognition, memory, and basic social skills. Many of these deficits are believe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b62eb004e5b25ed78960cea9c8060d0
http://europepmc.org/articles/PMC8019944

Inhibitor of DNA binding 2 (ID2) regulates the expression of developmental genes and tumorigenesis in ewing sarcoma.

Autor: Koppenhafer SL; Department of Pediatrics, Division of Pediatric Hematology/Oncology, University of Iowa, Iowa City, IA, 52242, USA., Goss KL; Department of Pediatrics, Division of Pediatric Hematology/Oncology, University of Iowa, Iowa City, IA, 52242, USA., Voigt E; Carver College of Medicine, University of Iowa, Iowa City, IA, 52242, USA., Croushore E; Department of Pediatrics, Division of Pediatric Hematology/Oncology, University of Iowa, Iowa City, IA, 52242, USA., Terry WW; Department of Pediatrics, Division of Pediatric Hematology/Oncology, University of Iowa, Iowa City, IA, 52242, USA., Ostergaard J; Department of Pediatrics, Division of Pediatric Hematology/Oncology, University of Minnesota, Minneapolis, MN, 55455, USA., Gordon PM; Department of Pediatrics, Division of Pediatric Hematology/Oncology, University of Minnesota, Minneapolis, MN, 55455, USA., Gordon DJ; Department of Pediatrics, Division of Pediatric Hematology/Oncology, University of Iowa, Iowa City, IA, 52242, USA. david-j-gordon@uiowa.edu.

Publikováno v: Oncogene [Oncogene] 2022 May; Vol. 41 (20), pp. 2873-2884. Date of Electronic Publication: 2022 Apr 14.