Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Emma E, Wolters"'
Autor:
Hayel Tuncel, Denise Visser, Tessa Timmers, Emma E. Wolters, Rik Ossenkoppele, Wiesje M. van der Flier, Bart N. M. van Berckel, Ronald Boellaard, Sandeep S. V. Golla
Publikováno v:
EJNMMI Research, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Background Dynamic PET imaging studies provide accurate estimates of specific binding, but also measure the relative tracer delivery (R1), which is a proxy for relative cerebral blood flow (rCBF). Recently, studies suggested that R1 obtained
Externí odkaz:
https://doaj.org/article/5b92fa28a272466696c487ff5bf1f7c8
Autor:
Hayel Tuncel, Ronald Boellaard, Emma M. Coomans, Marijke den Hollander-Meeuwsen, Erik F. J. de Vries, Andor W. J. M. Glaudemans, Paula Kopschina Feltes, David Vállez García, Sander C. J. Verfaillie, Emma E. Wolters, Steven P. Sweeney, J. Michael Ryan, Magnus Ivarsson, Berkley A. Lynch, Patrick Schober, Philip Scheltens, Robert C. Schuit, Albert D. Windhorst, Peter P. De Deyn, Bart N. M. van Berckel, Sandeep S. V. Golla
Publikováno v:
EJNMMI Research, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract [11C]UCB-J is a PET radioligand that binds to the presynaptic vesicle glycoprotein 2A. Therefore, [11C]UCB-J PET may serve as an in vivo marker of synaptic integrity. The main objective of this study was to evaluate the quantitative accuracy
Externí odkaz:
https://doaj.org/article/1d98093e987342dd9416579091feee0d
Autor:
Emma M. Coomans, Deborah N. Schoonhoven, Hayel Tuncel, Sander C. J. Verfaillie, Emma E. Wolters, Ronald Boellaard, Rik Ossenkoppele, Anouk den Braber, Wiep Scheper, Patrick Schober, Steven P. Sweeney, J. Michael Ryan, Robert C. Schuit, Albert D. Windhorst, Frederik Barkhof, Philip Scheltens, Sandeep S. V. Golla, Arjan Hillebrand, Alida A. Gouw, Bart N. M. van Berckel
Publikováno v:
Alzheimer’s Research & Therapy, Vol 13, Iss 1, Pp 1-13 (2021)
Abstract Background The mechanism of synaptic loss in Alzheimer’s disease is poorly understood and may be associated with tau pathology. In this combined positron emission tomography (PET) and magnetoencephalography (MEG) study, we aimed to investi
Externí odkaz:
https://doaj.org/article/0311b602bb364b2b9a39d6b57ce39995
Autor:
Tessa Timmers, Rik Ossenkoppele, Emma E. Wolters, Sander C. J. Verfaillie, Denise Visser, Sandeep S. V. Golla, Frederik Barkhof, Philip Scheltens, Ronald Boellaard, Wiesje M. van der Flier, Bart N. M. van Berckel
Publikováno v:
Alzheimer’s Research & Therapy, Vol 11, Iss 1, Pp 1-12 (2019)
Abstract Background Neuropathological studies have linked tau aggregates to neuronal loss. To describe the spatial distribution of neurofibrillary tangle pathology in post-mortem tissue, Braak staging has been used. The aim of this study was to exami
Externí odkaz:
https://doaj.org/article/6b929e091b814138b8c55d19c5638f74
A Head-to-Head Comparison Between Plasma pTau181 and Tau PET Along the Alzheimer's Disease Continuum
Autor:
Emma M. Coomans, Inge M.W. Verberk, Rik Ossenkoppele, Sander C.J. Verfaillie, Denise Visser, Mariam Gouda, Hayel Tuncel, Emma E. Wolters, Tessa Timmers, Albert D. Windhorst, Sandeep S.V. Golla, Philip Scheltens, Wiesje M. van, der Flier, Bart N.M. van Berckel, Charlotte E. Teunissen
Publikováno v:
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 64(3), 437-443
Coomans, E M, Verberk, I M W, Ossenkoppele, R, Verfaillie, S C J, Visser, D, Gouda, M, Tuncel, H, Wolters, E E, Timmers, T, Windhorst, A D, Golla, S S V, Scheltens, P, van, W M, Flier, D, van Berckel, B N M & Teunissen, C E 2023, ' A Head-to-Head Comparison Between Plasma pTau181 and Tau PET Along the Alzheimer's Disease Continuum ', Journal of nuclear medicine : official publication, Society of Nuclear Medicine, vol. 64, no. 3, pp. 437-443 . https://doi.org/10.2967/jnumed.122.264279
Coomans, E M, Verberk, I M W, Ossenkoppele, R, Verfaillie, S C J, Visser, D, Gouda, M, Tuncel, H, Wolters, E E, Timmers, T, Windhorst, A D, Golla, S S V, Scheltens, P, van, W M, Flier, D, van Berckel, B N M & Teunissen, C E 2023, ' A Head-to-Head Comparison Between Plasma pTau181 and Tau PET Along the Alzheimer's Disease Continuum ', Journal of nuclear medicine : official publication, Society of Nuclear Medicine, vol. 64, no. 3, pp. 437-443 . https://doi.org/10.2967/jnumed.122.264279
Both plasma tau phosphorylated at threonine-181 (pTau181) and tau PET show potential for detecting Alzheimer’s disease (AD) pathology and predicting clinical progression. In this study, we performed a head-to-head comparison between plasma pTau181
Autor:
Emma E Wolters, Rik Ossenkoppele, Sandeep SV Golla, Sander CJ Verfaillie, Tessa Timmers, Denise Visser, Hayel Tuncel, Emma M Coomans, Albert D Windhorst, Philip Scheltens, Wiesje M van der Flier, Ronald Boellaard, Bart NM van Berckel
Publikováno v:
NeuroImage: Clinical, Vol 25, Iss , Pp - (2020)
Background: Off-target [18F]flortaucipir (tau) PET binding in the choroid plexus causes spill-in into the nearby hippocampus, which may influence the correlation between [18F]flortaucipir binding and measures of cognition. Previously, we showed that
Externí odkaz:
https://doaj.org/article/a5bfc3b33d724e1bbda4df8af87d3498
Autor:
Emma E. Wolters, Sandeep S. V. Golla, Tessa Timmers, Rik Ossenkoppele, Chris W. J. van der Weijden, Philip Scheltens, Lothar Schwarte, Robert C. Schuit, Albert D. Windhorst, Frederik Barkhof, Maqsood Yaqub, Adriaan A. Lammertsma, Ronald Boellaard, Bart N. M. van Berckel
Publikováno v:
EJNMMI Research, Vol 8, Iss 1, Pp 1-5 (2018)
Abstract Background Off-target binding in the choroid plexus (CP) may cause spill-in of the tau PET tracer [18F] flortaucipir into the adjacent hippocampus region. The impact of this spill-in on hippocampal uptake was assessed using a novel partial v
Externí odkaz:
https://doaj.org/article/d6b3c1a07bea484b8df7169ab0e27467
Autor:
Denise Visser, Hayel Tuncel, Rik Ossenkoppele, Maqsood Yaqub, Emma E. Wolters, Tessa Timmers, Emma Weltings, Emma M. Coomans, Marijke E. den Hollander, Wiesje M. van der Flier, Bart N.M. van Berckel, Sandeep S.V. Golla
Publikováno v:
Journal of Nuclear Medicine. 64:281-286
Autor:
Emma M Coomans, Jori Tomassen, Rik Ossenkoppele, Sandeep S V Golla, Marijke den Hollander, Lyduine E Collij, Emma Weltings, Sophie M van der Landen, Emma E Wolters, Albert D Windhorst, Frederik Barkhof, Eco J C de Geus, Philip Scheltens, Pieter Jelle Visser, Bart N M van Berckel, Anouk den Braber
Publikováno v:
Brain, 145(10), 3571-3581. Oxford University Press
Coomans, E M, Tomassen, J, Ossenkoppele, R, Golla, S S V, Den Hollander, M, Collij, L E, Weltings, E, Van Der Landen, S, Wolters, E E, Windhorst, A D, Barkhof, F, de Geus, E J C, Scheltens, P, Visser, P J, Van Berckel, B N M & den Braber, A 2022, ' Genetically identical twins show comparable tau PET load and spatial distribution ', Brain, vol. 145, no. 10, pp. 3571-3581 . https://doi.org/10.1093/brain/awac004
Coomans, E M, Tomassen, J, Ossenkoppele, R, Golla, S S V, den Hollander, M, Collij, L E, Weltings, E, van der Landen, S, Wolters, E E, Windhorst, A D, Barkhof, F, de Geus, E J C, Scheltens, P, Visser, P J, van Berckel, B N M & den Braber, A 2022, ' Genetically identical twins show comparable tau PET load and spatial distribution ', Brain, vol. 145, no. 10, pp. 3571-3581 . https://doi.org/10.1093/brain/awac004
Coomans, E M, Tomassen, J, Ossenkoppele, R, Golla, S S V, Den Hollander, M, Collij, L E, Weltings, E, Van Der Landen, S, Wolters, E E, Windhorst, A D, Barkhof, F, de Geus, E J C, Scheltens, P, Visser, P J, Van Berckel, B N M & den Braber, A 2022, ' Genetically identical twins show comparable tau PET load and spatial distribution ', Brain, vol. 145, no. 10, pp. 3571-3581 . https://doi.org/10.1093/brain/awac004
Coomans, E M, Tomassen, J, Ossenkoppele, R, Golla, S S V, den Hollander, M, Collij, L E, Weltings, E, van der Landen, S, Wolters, E E, Windhorst, A D, Barkhof, F, de Geus, E J C, Scheltens, P, Visser, P J, van Berckel, B N M & den Braber, A 2022, ' Genetically identical twins show comparable tau PET load and spatial distribution ', Brain, vol. 145, no. 10, pp. 3571-3581 . https://doi.org/10.1093/brain/awac004
Tau accumulation starts during the preclinical phase of Alzheimer’s disease and is closely associated with cognitive decline. For preventive purposes, it is important to identify factors associated with tau accumulation and spread. Studying genetic
Autor:
Victor L. Villemagne, Oskar Hansson, Angèle Gayet-Ageron, Giovanni B. Frisoni, Rik Ossenkoppele, Emiliano Albanese, Nicholas J. Ashton, Valentina Garibotto, Alexander Drzezga, Cristina Festari, Marina Boccardi, G. rard N. Bischof, Konstantinos Chiotis, Alessandra Dodich, Gil D. Rabinovici, Agneta Nordberg, Maria C. Carrillo, Antoine Leuzy, Emma E. Wolters, Bengt Winblad, Martin A. Walter
Publikováno v:
European journal of nuclear medicine and molecular imaging 48(13), 4525-4531 (2021). doi:10.1007/s00259-021-05549-z
Eur J Nucl Med Mol Imaging
Eur J Nucl Med Mol Imaging
The 2017 Alzheimer's disease (AD) Strategic Biomarker Roadmap (SBR) structured the validation of AD diagnostic biomarkers into 5 phases, systematically assessing analytical validity (Phases 1-2), clinical validity (Phases 3-4), and clinical utility (