Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Emma Dave"'
Autor:
Isabel Guerrero Montero, Katarzyna Magdalena Dolata, Rabea Schlüter, Gilles Malherbe, Susanne Sievers, Daniela Zühlke, Thomas Sura, Emma Dave, Katharina Riedel, Colin Robinson
Publikováno v:
Microbial Cell Factories, Vol 18, Iss 1, Pp 1-15 (2019)
Abstract Background The Twin-arginine translocation (Tat) pathway of Escherichia coli has great potential for the export of biopharmaceuticals to the periplasm due to its ability to transport folded proteins, and its proofreading mechanism that allow
Externí odkaz:
https://doaj.org/article/399c3e37f4cd4ef5837d604c5b84ca95
Publikováno v:
BioTechniques. 66:171-178
Fractionation in Gram-negative bacteria is used to identify the subcellular localization of proteins, in particular the localization of exported recombinant proteins. The process of cell fractionation can be fraught with cross-contamination issues an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1adca15eb6e97aff66b8686141595fd
https://doi.org/10.2144/btn-2018-0135
https://doi.org/10.2144/btn-2018-0135
Autor:
Susanne Sievers, Daniela Zühlke, Thomas Sura, Katharina Riedel, Colin Robinson, Gilles Malherbe, Emma Dave, Rabea Schlüter, Katarzyna Magdalena Dolata, Isabel Guerrero Montero
Publikováno v:
Microbial Cell Factories, Vol 18, Iss 1, Pp 1-15 (2019)
Microbial Cell Factories
Microbial Cell Factories
Background The Twin-arginine translocation (Tat) pathway of Escherichia coli has great potential for the export of biopharmaceuticals to the periplasm due to its ability to transport folded proteins, and its proofreading mechanism that allows correct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0905b1f3f73a1ac1933d58e44964f850
http://link.springer.com/article/10.1186/s12934-019-1071-7
http://link.springer.com/article/10.1186/s12934-019-1071-7
Autor:
Kirsty L. Richards, Humphreys David Paul, Amber R. Peswani, Stephen J. W. Busby, Colin Robinson, Emma Dave, Cedric Aubry, Matthew Allen, Douglas F. Browning, Chillel Jawara, Mickael Labrit, Isabel Guerrero Montero
Publikováno v:
Biotechnology and Bioengineering
Escherichia coli is a heavily used platform for the production of biotherapeutic and other high‐value proteins, and a favored strategy is to export the protein of interest to the periplasm to simplify downstream processing and facilitate disulfide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d34cd83fa02765351b257c8abde84f7
https://publications.aston.ac.uk/id/eprint/43445/1/Biotech_Bioengineering_2019_Guerrero_Montero_Escherichia_coli_TatExpress_strains_export_several_g_L_human_growth.pdf
https://publications.aston.ac.uk/id/eprint/43445/1/Biotech_Bioengineering_2019_Guerrero_Montero_Escherichia_coli_TatExpress_strains_export_several_g_L_human_growth.pdf
Autor:
Alastair D. G. Lawson, Ralph Adams, Joanne E. Compson, Tim Kopotsha, Michael Airey, Hanna Hailu, David Paul Humphreys, Oliver Zaccheo, Kaushik Sarkar, Mark Jairaj, Wild Gavin Barry, Andrew M. Ventom, Sarah L. Dugdale, Louis Christodoulou, Emma Dave, Sarah Malcolm, Diane Marshall, Alison Turner, Bruce Carrington, James T. Heads, Miren Zamacona, Sam Philip Heywood
Publikováno v:
mAbs
An antibody format, termed Fab-dsFv, has been designed for clinical indications that require monovalent target binding in the absence of direct Fc receptor (FcR) binding while retaining substantial serum presence. The variable fragment (Fv) domain of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a7a3913eb730ba743647c72b63a2c22
http://europepmc.org/articles/PMC5058625
http://europepmc.org/articles/PMC5058625
Autor:
Mark Jairaj, Emma Dave, Ralph Adams, Shauna West, Laura Griffin, Oliver Zaccheo, Sam Philip Heywood, David Paul Humphreys, Tom Ceska, Joanne E. Compson, Alastair Dg. Lawson, Terry Baker
Publikováno v:
mAbs
We generated an anti-albumin antibody, CA645, to link its Fv domain to an antigen-binding fragment (Fab), thereby extending the serum half-life of the Fab. CA645 was demonstrated to bind human, cynomolgus, and mouse serum albumin with similar affinit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::614e035bbe6683461c760abeb846c148
https://doi.org/10.1080/19420862.2016.1185581
https://doi.org/10.1080/19420862.2016.1185581
Autor:
Emma Davey, Geoffrey K. Isbister
Publikováno v:
Toxicology Communications, Vol 7, Iss 1 (2023)
AbstractMethotrexate toxicity following intravenous (IV) methotrexate is well reported, but there is less information on accidental daily dosing of a prescribed weekly dose of oral methotrexate. A 70 year old female presented following accidentally t
Externí odkaz:
https://doaj.org/article/d64e0b6cd70345a3b68f9789cbd8ce0d
Autor:
Emma Davé, Oliver Durrant, Neha Dhami, Joanne Compson, Janice Broadbridge, Sophie Archer, Asher Maroof, Kevin Whale, Karelle Menochet, Pierre Bonnaillie, Emily Barry, Gavin Wild, Claude Peerboom, Pallavi Bhatta, Mark Ellis, Matthew Hinchliffe, David P. Humphreys, Sam P. Heywood
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTTrYbe® is an Fc-free therapeutic antibody format, capable of engaging up to three targets simultaneously, with long in vivo half-life conferred by albumin binding. This format is shown by small-angle X-ray scattering to be conformationally f
Externí odkaz:
https://doaj.org/article/da5a5f25917d459295f40b2ca83010e7
Publikováno v:
Microbiology. 141:1839-1849
Isogenic strains of Escherichia coli W3110 containing pyruvate dehydrogenase complexes with three (wild-type), two or one lipoyl domains per lipoate acetyltransferase (E2p) chain, were constructed. The maximum growth rates (max) for batch cultures gr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::452f58a3e0eaf1fd11ef0c7271942a5e
https://doi.org/10.1099/13500872-141-8-1839
https://doi.org/10.1099/13500872-141-8-1839
Autor:
Anne M. Cook, Irena Wowk, Atif H. Asghar, Mark S. Thomas, Emma Dave, Kirsty Agnoli, Sravanthi Shastri
Publikováno v:
Microbiology (Reading, England). 157(Pt 2)
The opportunistic pathogen Burkholderia cenocepacia produces the siderophores ornibactin and pyochelin under iron-restricted conditions. Biosynthesis of both siderophores requires the involvement of non-ribosomal peptide synthetases (NRPSs). Using a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57e4d2a090cf91b43e2aabed6f1ede8a
https://pubmed.ncbi.nlm.nih.gov/20966087
https://pubmed.ncbi.nlm.nih.gov/20966087