Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Emma Castrique"'
Autor:
Hannah Taylor, Neil Barua, Alison Bienemann, Marcella Wyatt, Emma Castrique, Rebecca Foster, Matthias Luz, Christian Fibiger, Erich Mohr, Steven Gill
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e56186 (2013)
BACKGROUND: Despite promising early results, clinical trials involving the continuous delivery of recombinant methionyl human glial cell line-derived neurotrophic factor (r-metHuGDNF) into the putamen for the treatment of Parkinson's disease have sho
Externí odkaz:
https://doaj.org/article/da51f87d44c14703ae57bb88d2c36b1e
Autor:
Emma Castrique, Alison Bienemann, Marcella J Wyatt, Hannah Taylor, John A. Pugh, Cameron W. McLeod, Alan G. Cox, Steven S. Gill, Edward White
Publikováno v:
Journal of Neuro-Oncology. 108:77-88
Glioblastoma multiforme (GBM) is the most common and most aggressive form of intrinsic brain tumour. Despite standard treatment involving surgical resection, chemotherapy and radiotherapy this disease remains incurable with the majority of tumours re
Autor:
Hannah Taylor, A.S. Bienemann, Emma Castrique, Max Woolley, David Johnson, Marcella J Wyatt, G. Murray, Neil U Barua, Edward White, Steven S. Gill
Publikováno v:
Journal of Neuroscience Methods. 203:284-291
Convection-enhanced delivery (CED) is a promising technique for the administration of therapeutic agents such as cytotoxics, neurotrophins and enzymes to the brain. In this study we describe the development of an implantable catheter system that is c
Autor:
James D. Leggett, SA Wood, Stafford L. Lightman, YM Kershaw, Emma Castrique, Helen C. Atkinson
Publikováno v:
Endocrinology
We have examined the effects of acute administration of the cannabinoid receptor type 1 (CB1) antagonist AM251 on the rat hypothalamic-pituitary-adrenal (HPA) axis with respect to both gender and time of day. Blood samples were collected from conscio
Autor:
Stafford L. Lightman, SA Wood, Helen C. Atkinson, YM Kershaw, Emma Castrique, Crispin C. Wiles
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 294:E1011-E1022
The aim of this study was to investigate fast corticosteroid feedback of the hypothalamic-pituitary-adrenal (HPA) axis under basal conditions, in particular the role of the mineralocorticoid receptor. Blood samples were collected every 5 min from con
Autor:
Max Woolley, Emma Castrique, C. Irving, Marcella J Wyatt, A.S. Bienemann, David Johnson, Neil U Barua, Steven S. Gill, Owen Lewis
Publikováno v:
Journal of neuroscience methods. 220(1)
Background Convection-enhanced delivery (CED) is currently under investigation for delivering therapeutic agents to subcortical targets in the brain. Direct delivery of therapies to the cerebral cortex, however, remains a significant challenge. New m
Autor:
Steven S. Gill, Hannah Taylor, Chotirote Bunnun, Marcella J Wyatt, Emma Castrique, Alison Bienemann, Edward White
Publikováno v:
The journal of gene medicine. 13(5)
Background Direct adenoviral vector injections into the brain have been used in clinical trials to treat patients with high-grade gliomas. However, a recent phase 3 trial using first-generation vectors failed to demonstrate significant survival benef
Autor:
Chotirote Bunnun, Alison Bienemann, Hannah Taylor, Emma Castrique, Steven S Gill, Edward White, Miguel Sena-Esteves
Publikováno v:
Human gene therapy. 22(2)
Convection-enhanced delivery (CED) of recombinant adeno-associated virus (rAAV) vectors is a promising approach for delivery of therapeutic transgenes to the brain. In this study we have systematically examined vector dosing in vivo. Infusions of rAA
Publikováno v:
The Journal of Endocrinology
In rats, a shift from somatotroph dominance to lactotroph dominance during pregnancy and lactation is well reported. Somatotroph to lactotroph transdifferentiation and increased lactotroph mitotic activity are believed to account for this and associa
Publikováno v:
Frontiers in Neuroendocrinology. 27:49-50