Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Emma C. Reck"'
Autor:
Vaibhav Sidarala, Jie Zhu, Elena Levi-D’Ancona, Gemma L. Pearson, Emma C. Reck, Emily M. Walker, Brett A. Kaufman, Scott A. Soleimanpour
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Sidarala et al. examine the importance of the mitochondrial structural proteins, Mitofusins 1 and 2 (Mfn1/2), in diabetes. They find that Mfn1/2 control blood glucose by preserving mitochondrial DNA content, rather than mitochondrial structure.
Externí odkaz:
https://doaj.org/article/247caaeb45e74492958ffd5942fda4db
Autor:
Vaibhav Sidarala, Gemma L. Pearson, Vishal S. Parekh, Benjamin Thompson, Lisa Christen, Morgan A. Gingerich, Jie Zhu, Tracy Stromer, Jianhua Ren, Emma C. Reck, Biaoxin Chai, John A. Corbett, Thomas Mandrup-Poulsen, Leslie S. Satin, Scott A. Soleimanpour
Publikováno v:
JCI Insight, Vol 5, Iss 24 (2020)
Inflammatory damage contributes to β cell failure in type 1 and 2 diabetes (T1D and T2D, respectively). Mitochondria are damaged by inflammatory signaling in β cells, resulting in impaired bioenergetics and initiation of proapoptotic machinery. Hen
Externí odkaz:
https://doaj.org/article/5621b7dc174d44beb66d61a7da10a016
Autor:
Gemma L. Pearson, Emily M. Walker, Nathan Lawlor, Anne Lietzke, Vaibhav Sidarala, Jie Zhu, Tracy Stromer, Emma C. Reck, Jin Li, Aaron Renberg, Kawthar Mohamed, Vishal S. Parekh, Irina X. Zhang, Benjamin Thompson, Deqiang Zhang, Sarah A. Ware, Leena Haataja, Stephen C.J. Parker, Peter Arvan, Lei Yin, Brett A. Kaufman, Leslie S. Satin, Lori Sussel, Michael L. Stitzel, Scott A. Soleimanpour
Mitochondrial dysfunction is a hallmark of metabolic diseases, including diabetes, yet the consequences of mitochondrial damage in metabolic tissues are often unclear. Here, we report that mitochondrial dysfunction engages a retrograde (mitonuclear)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e517b42d9cbfc566e59056e5b624ac9
https://doi.org/10.1101/2022.08.02.502357
https://doi.org/10.1101/2022.08.02.502357
Autor:
Jie Zhu, Nathan Lawlor, Gemma L. Pearson, Emily M. Walker, Michael L. Stitzel, Scott A. Soleimanpour, Emma C. Reck
Publikováno v:
Diabetes. 70
Mitochondrial function is pivotal to β-cell competence. The mitochondrial life cycle balances mitochondrial biogenesis and turnover (mitophagy) to ensure optimal metabolic function. Human type 2 diabetic (T2D) β-cells are known to develop mitochond
Autor:
Emma C. Reck, Brett A. Kaufman, Gemma L. Pearson, Vaibhav Sidarala, Scott A. Soleimanpour, Jie Zhu
The dynamin-like GTPases Mitofusin 1 and 2 (Mfn1 and Mfn2) are essential for mitochondrial function, which has been principally attributed to their regulation of fission/fusion dynamics. Here, we report that Mfn1 and 2 are critical for glucose-stimul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a0a751c75bd07541e04f46ef3615f333
https://doi.org/10.21203/rs.3.rs-310904/v1
https://doi.org/10.21203/rs.3.rs-310904/v1
Autor:
John A. Corbett, Emma C. Reck, Scott A. Soleimanpour, Biaoxin Chai, Morgan A. Gingerich, Benjamin Thompson, Lisa Christen, Thomas Mandrup-Poulsen, Vishal S. Parekh, Gemma L. Pearson, Vaibhav Sidarala, Leslie S. Satin, Jianhua Ren, Jie Zhu, Tracy Stromer
Publikováno v:
JCI Insight
JCI Insight, Vol 5, Iss 24 (2020)
Sidarala, V, Pearson, G L, Parekh, V S, Thompson, B, Christen, L, Gingerich, M A, Zhu, J, Stromer, T, Ren, J, Reck, E C, Chai, B, Corbett, J A, Mandrup-Poulsen, T, Satin, L S & Soleimanpour, S A 2020, ' Mitophagy protects beta cells from inflammatory damage in diabetes ', JCI insight, vol. 5, no. 24, 141138 . https://doi.org/10.1172/jci.insight.141138
JCI Insight, Vol 5, Iss 24 (2020)
Sidarala, V, Pearson, G L, Parekh, V S, Thompson, B, Christen, L, Gingerich, M A, Zhu, J, Stromer, T, Ren, J, Reck, E C, Chai, B, Corbett, J A, Mandrup-Poulsen, T, Satin, L S & Soleimanpour, S A 2020, ' Mitophagy protects beta cells from inflammatory damage in diabetes ', JCI insight, vol. 5, no. 24, 141138 . https://doi.org/10.1172/jci.insight.141138
Inflammatory damage contributes to β-cell failure in type 1 and 2 diabetes (T1D and T2D). Mitochondria are damaged by inflammatory signaling in β-cells, resulting in impaired bioenergetics and initiation of pro-apoptotic machinery. Hence, the ident
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d95489b3a754e5976312f493596ac093
https://doi.org/10.1101/2020.06.07.138917
https://doi.org/10.1101/2020.06.07.138917