Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Emma C. Hollands"'
Autor:
Tim Dale, Helen J. Meadows, Andrew J. Powell, Jeffrey J. Clare, Emma C. Hollands, Andrew Baxter, Derek J. Trezise
Publikováno v:
SLAS Discovery. 14:769-780
Gamma-amino butyric acid (GABA)-activated Cl- channels are critical mediators of inhibitory postsynaptic potentials in the CNS. To date, rational design efforts to identify potent and selective GABA(A) subtype ligands have been hampered by the absenc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b16973a6e695ef5455a221d4f19cf91a
https://doi.org/10.1177/1087057109335675
https://doi.org/10.1177/1087057109335675
Autor:
Emma C. Hollands, Derek J. Trezise, Victoria H John, David L. Downie, Mao Xiang Chen, Tim Dale, Leanne Partington, Helen J. Meadows
Publikováno v:
SLAS Discovery. 12:50-60
Planar array electrophysiology techniques were applied to assays for modulators of recombinant hIK and hSK3 Ca2+-activated K+ channels. In CHO-hIK-expressing cells, under asymmetric K+ gradients, small-molecule channel activators evoked time- and vol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d70bd99a3951d5db183cbed6671267b8
https://doi.org/10.1177/1087057106294920
https://doi.org/10.1177/1087057106294920
Autor:
Marinella Antolini, Silvia Bison, Kevin D. Read, Alessandro Gozzi, Ilaria Sartori, Martin J. Gunthorpe, Giuseppe Alvaro, Charles H. Large, Catherine H. Gill, Jo C. Neill, Emma C. Hollands, Nagi F. Idris, Davide Quarta
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 338(1)
Sodium channel inhibition is a well precedented mechanism used to treat epilepsy and other hyperexcitability disorders. The established sodium channel blocker and broad-spectrum anticonvulsant lamotrigine is also effective in the treatment of bipolar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f7698852dd5c1ff1dc40365e4d24927
https://pubmed.ncbi.nlm.nih.gov/21487071
https://pubmed.ncbi.nlm.nih.gov/21487071
Publikováno v:
Molecular BioSystems. 3:714
Population patch clamp (PPC) is a novel high throughput planar array electrophysiology technique that allows ionic currents to be recorded from populations of cells under voltage clamp. For the drug discovery pharmacologist, PPC promises greater spee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8f49f5cd9d60f63a98cbd48ea5a1990
https://doi.org/10.1039/b706152h
https://doi.org/10.1039/b706152h