Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Emma C Fink"'
Autor:
Katherine A Donovan, Jian An, Radosław P Nowak, Jingting C Yuan, Emma C Fink, Bethany C Berry, Benjamin L Ebert, Eric S Fischer
Publikováno v:
eLife, Vol 7 (2018)
In historical attempts to treat morning sickness, use of the drug thalidomide led to the birth of thousands of children with severe birth defects. Despite their teratogenicity, thalidomide and related IMiD drugs are now a mainstay of cancer treatment
Externí odkaz:
https://doaj.org/article/eac70f24e93a4854852d018b4f301d58
Autor:
Rachid Safi, Suzanne E. Wardell, Paige Watkinson, Xiaodi Qin, Marissa Lee, Sunghee Park, Taylor Krebs, Emma L. Dolan, Adam Blattler, Toshiya Tsuji, Surendra Nayak, Marwa Khater, Celia Fontanillo, Madeline A. Newlin, Megan L. Kirkland, Yingtian Xie, Henry Long, Emma C. Fink, Sean W. Fanning, Scott Runyon, Myles Brown, Shuichan Xu, Kouros Owzar, John D. Norris, Donald P. McDonnell
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Most prostate cancers express the androgen receptor (AR), and tumor growth and progression are facilitated by exceptionally low levels of systemic or intratumorally produced androgens. Thus, absolute inhibition of the androgen signaling axis
Externí odkaz:
https://doaj.org/article/46ae3691cddb47bb9982590cd3da970d
Autor:
Rob S. Sellar, Adam S. Sperling, Mikołaj Słabicki, Jessica A. Gasser, Marie E. McConkey, Katherine A. Donovan, Nada Mageed, Dylan N. Adams, Charles Zou, Peter G. Miller, Ravi K. Dutta, Steffen Boettcher, Amy E. Lin, Brittany Sandoval, Vanessa A. Quevedo Barrios, Veronica Kovalcik, Jonas Koeppel, Elizabeth K. Henderson, Emma C. Fink, Lu Yang, Anthony Chan, Sheela Pangeni Pokharel, Erik J. Bergstrom, Rajan Burt, Namrata D. Udeshi, Steven A. Carr, Eric S. Fischer, Chun-Wei Chen, Benjamin L. Ebert
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 16 (2022)
Targeted protein degradation is a rapidly advancing and expanding therapeutic approach. Drugs that degrade GSPT1 via the CRL4CRBN ubiquitin ligase are a new class of cancer therapy in active clinical development with evidence of activity against acut
Externí odkaz:
https://doaj.org/article/81fae13f3404407c97508eb3a6337c9d
Autor:
Dennis Gillingham, Jessica A. Gasser, Rob S. Sellar, Eric S. Fischer, Max Jan, Todd R. Golub, Manisha Manojkumar, Nicolas H. Thomä, Quinlan L. Sievers, Claudia Scholl, Stefan Fröhling, Li R. Wang, Zuzanna Kozicka, Katherine A. Donovan, Emma C. Fink, Adam S. Sperling, Yen-Der Li, Steven M. Corsello, Mikolaj Slabicki, Richard D. Bunker, Georg Petzold, Benjamin L. Ebert, Dakota Suchyta, Jonas Koeppel
Publikováno v:
Nature
Molecular glue compounds induce protein–protein interactions that, in the context of a ubiquitin ligase, lead to protein degradation. Unlike traditional enzyme inhibitors, these molecular glue degraders act substoichiometrically to catalyse the rap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59f945e27008c0da8a9d7dd121f5cde3
https://doi.org/10.1038/s41586-020-2374-x
https://doi.org/10.1038/s41586-020-2374-x
Autor:
Tanya Svinkina, James A. Kennedy, Emma C. Fink, D. R. Mani, Benjamin L. Ebert, Dylan N. Adams, Steven A. Carr, Saurav D. Haldar, Michelle C. Chen, Andrew A Guirguis, Namrata D. Udeshi, Brian J. Liddicoat, Marie McConkey, Andrew T. Nguyen
Publikováno v:
Blood. 132:1535-1544
Thalidomide and its derivatives, lenalidomide and pomalidomide, are clinically effective treatments for multiple myeloma and myelodysplastic syndrome with del(5q). These molecules lack activity in murine models, limiting investigation of their therap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::654ed928b014667c3dfe3d20b6400bea
https://doi.org/10.1182/blood-2018-05-852798
https://doi.org/10.1182/blood-2018-05-852798
Autor:
Mikolaj Slabicki, Eric Kuhn, Quinlan L. Sievers, Namrata D. Udeshi, Jessica A. Gasser, Adam S. Sperling, Rob S. Sellar, Hasmik Keshishian, Michael Burgess, Elyse A. Olesinski, Benjamin L. Ebert, Steven A. Carr, Rohan Sharma, Anthony Letai, Peter Miller, Shruti Bhatt, Max Jan, Brian J. Liddicoat, Mariateresa Fulciniti, Emma C. Fink, Dylan N. Adams, Nikhil C. Munshi
Publikováno v:
Blood. 134(2)
Pharmacologic agents that modulate ubiquitin ligase activity to induce protein degradation are a major new class of therapeutic agents, active in a number of hematologic malignancies. However, we currently have a limited understanding of the determin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9800984582c3e896463113104f0e0c72
https://pubmed.ncbi.nlm.nih.gov/31296542
https://pubmed.ncbi.nlm.nih.gov/31296542
Autor:
Benjamin L. Ebert, Katherine A. Donovan, Bethany C Berry, Radosław P. Nowak, Emma C. Fink, Eric S. Fischer, Jian An, Jingting C. Yuan
Publikováno v:
eLife, Vol 7 (2018)
In historical attempts to treat morning sickness, use of the drug thalidomide led to the birth of thousands of children with severe birth defects. Despite their teratogenicity, thalidomide and related IMiD drugs are now a mainstay of cancer treatment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49537a577033a4eaa72460268436930d
https://doi.org/10.7554/elife.38430
https://doi.org/10.7554/elife.38430
Autor:
Benjamin L. Ebert, Kimberly A. Hartwell, David E. Root, Emma C. Fink, L. Jordan Breyfogle, Fatima Al-Shahrour, Rebekka K. Schneider, Pablo Peña, Glenn S. Cowley, Marie McConkey, Lisa P. Chu, Rishi V. Puram, Ann Mullally, Peter Miller, Michael G. Kharas, Marcus Järås
Publikováno v:
The Journal of Experimental Medicine
Targeting Csnk1a1 provides a potential therapeutic approach for AML associated with nonmutated Tp53.
Despite extensive insights into the underlying genetics and biology of acute myeloid leukemia (AML), overall survival remains poor and new thera
Despite extensive insights into the underlying genetics and biology of acute myeloid leukemia (AML), overall survival remains poor and new thera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dba7e8beb58902a0ede9e6de5e18a5f3
https://doi.org/10.1084/jem.20131033
https://doi.org/10.1084/jem.20131033
Publikováno v:
Journal of Biological Chemistry. 285:7525-7536
Saccharomyces cerevisiae Esc2p is a member of a conserved family of proteins that contain small ubiquitin-like modifier (SUMO)-like domains. It has been implicated in transcriptional silencing and shown to interact with the silencing protein Sir2p in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0368c9adb42de83e75090befa2b3b538
https://doi.org/10.1074/jbc.m109.016360
https://doi.org/10.1074/jbc.m109.016360