Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Emma C, Walker"'
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Introduction: The actin cytoskeleton remodels to enable diverse processes essential to immunity, such as cell adhesion, migration and phagocytosis. A panoply of actin-binding proteins regulate these rapid rearrangements to induce actin-based shape ch
Externí odkaz:
https://doaj.org/article/84c6883be0104be69164bf027f0c018a
Autor:
Benjamin Ng, Anissa A. Widjaja, Sivakumar Viswanathan, Jinrui Dong, Sonia P. Chothani, Stella Lim, Shamini G. Shekeran, Jessie Tan, Narelle E. McGregor, Emma C. Walker, Natalie A. Sims, Sebastian Schafer, Stuart A. Cook
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Loss of function (LOF) in IL11RA infers IL11 signaling as important for fertility, fibrosis, inflammation and incompletely penetrant craniosynostosis. The impact of LOF in IL11 has not been characterized. We generated IL11 knockout (Il11 −
Externí odkaz:
https://doaj.org/article/d5124096b01d4998921d03195394e3df
Autor:
Emma C Walker, Kim Truong, Narelle E McGregor, Ingrid J Poulton, Tsuyoshi Isojima, Jonathan H Gooi, T John Martin, Natalie A Sims
Publikováno v:
eLife, Vol 9 (2020)
Bone strength is determined by its dense cortical shell, generated by unknown mechanisms. Here we use the Dmp1Cre:Socs3f/f mouse, with delayed cortical bone consolidation, to characterise cortical maturation and identify control signals. We show that
Externí odkaz:
https://doaj.org/article/0e2e31dc062d473bb947c073d0b97fe7
Autor:
Natalie K Y Wee, Thaísa F C de Lima, Narelle E McGregor, Emma C Walker, Ingrid J Poulton, Martha Blank, Natalie A Sims
Publikováno v:
Journal of Endocrinology. 255:25-37
Bone strength is partially determined during cortical bone consolidation, a process comprising coalescence of peripheral trabecular bone and its progressive mineralisation. Mice with genetic deletion of suppressor of cytokine signalling 3 (Socs3), an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07fa6ee0179ed0ac00e4eb23688c03de
https://doi.org/10.1530/joe-22-0084
https://doi.org/10.1530/joe-22-0084
Autor:
Dae-Chul Cho, Holly J. Brennan, Rachelle W. Johnson, Ingrid J. Poulton, Jonathan H. Gooi, Brett A. Tonkin, Narelle E. McGregor, Emma C. Walker, David J. Handelsman, T. J. Martin, Natalie A. Sims
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
The strength of long bones is determined by coalescence of trabeculae during corticalization. Here the authors show that this process is regulated by SOCS3 via a mechanism dependent on IL-6 and expression of sex hormones.
Externí odkaz:
https://doaj.org/article/b957b83bc219453cadc23acf2a9623c9
Autor:
Tsuyoshi Isojima, Emma C Walker, Ingrid J Poulton, Narelle E McGregor, Ian P Wicks, Jonathan H Gooi, T John Martin, Natalie A Sims
Publikováno v:
Journal of Bone and Mineral Research. 37:1876-1890
Bone strength is determined by the structure and composition of its thickened outer shell (cortical bone), yet the mechanisms controlling cortical consolidation are poorly understood. Cortical bone maturation depends on SOCS3-mediated suppression of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9647c0846eb8f2c50912bc82a26a860c
https://doi.org/10.1002/jbmr.4654
https://doi.org/10.1002/jbmr.4654
Autor:
Martha Blank, Narelle E. McGregor, Lynn Rowley, Louise H. W. Kung, Blessing Crimeen‐Irwin, Ingrid J. Poulton, Emma C. Walker, Jonathan H. Gooi, Shireen R. Lamandé, Natalie A. Sims, John F. Bateman
Publikováno v:
Journal of Cellular and Molecular Medicine. 26:4021-4031
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f8b872fe49abac2ad200a57b7f7f088
https://doi.org/10.1111/jcmm.17437
https://doi.org/10.1111/jcmm.17437
Autor:
Narelle E McGregor, Emma C Walker, Audrey SM Chan, Ingrid J Poulton, Ellie H‐J Cho, Sara H Windahl, Natalie A Sims
Publikováno v:
Journal of Bone and Mineral Research. 37:547-558
Cortical bone develops and changes in response to mechanical load, which is sensed by bone-embedded osteocytes. The bone formation response to load depends on STAT3 intracellular signals, which are upregulated after loading and are subject to negativ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7db53ccfd0d2c93dbdf8265f408cddc8
https://doi.org/10.1002/jbmr.4484
https://doi.org/10.1002/jbmr.4484
Autor:
Matthew T Aliota, Elizabeth A Caine, Emma C Walker, Katrina E Larkin, Erwin Camacho, Jorge E Osorio
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 10, Iss 5, p e0004750 (2016)
[This corrects the article DOI: 10.1371/journal.pntd.0004682.].
Externí odkaz:
https://doaj.org/article/2904bfaec84245e6bd516dece4d17341
Autor:
Matthew T Aliota, Emma C Walker, Alexander Uribe Yepes, Ivan Dario Velez, Bruce M Christensen, Jorge E Osorio
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 10, Iss 4, p e0004677 (2016)
BACKGROUND:New approaches to preventing chikungunya virus (CHIKV) are needed because current methods are limited to controlling mosquito populations, and they have not prevented the invasion of this virus into new locales, nor have they been sufficie
Externí odkaz:
https://doaj.org/article/4a97627e384d466f80ed4101eb618c1c