Distribution of the branched-chain α-ketoacid dehydrogenase complex E1α subunit and glutamate dehydrogenase in the human brain and their role in neuro-metabolism

Autor: Emma Brookes, Myra E. Conway, Jonathon Hull, Seth Love, Marcela Usmari Moraes

Publikováno v: Hull, J, Usmari Moraes, M, Brookes, E, Love, S & Conway, M E 2018, ' Distribution of the branched-chain α-ketoacid dehydrogenase complex E1α subunit and glutamate dehydrogenase in the human brain and their role in neuro-metabolism ', Neurochemistry International, vol. 112, pp. 49-58 . https://doi.org/10.1016/j.neuint.2017.10.014

Glutamate is the major excitatory neurotransmitter of the central nervous system, with the branched-chain amino acids (BCAAs) acting as key nitrogen donors for de novo glutamate synthesis. Despite the importance of these major metabolites, their meta

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