Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Emma Branigan"'
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
The mechanism of ubiquitin transfer from the ubiquitin-conjugated E2 enzyme (E2~Ub) to the substrate is still under debate. Here, the authors use FRET assays to show that RING E3 ligases transfer ubiquitin to the substrate from a closed E2~Ub conform
Externí odkaz:
https://doaj.org/article/804ead47bc3a4058bfc76e0bf7df8968
Autor:
Francisco Bustos, Anna Segarra-Fas, Viduth K. Chaugule, Lennart Brandenburg, Emma Branigan, Rachel Toth, Thomas Macartney, Axel Knebel, Ronald T. Hay, Helen Walden, Greg M. Findlay
Publikováno v:
Cell Reports, Vol 23, Iss 6, Pp 1599-1611 (2018)
Summary: X-linked intellectual disability (XLID) is a heterogeneous syndrome affecting mainly males. Human genetics has identified >100 XLID genes, although the molecular and developmental mechanisms underpinning this disorder remain unclear. Here, w
Externí odkaz:
https://doaj.org/article/a7ffd6fa9df048268b625e400ceb92e8
Publikováno v:
Articles
An analog holographic wavefront sensor (AHWFS), for measurement of low and high order (defocus and spherical aberration) aberration modes has been developed as volume phase holograms in a photopolymer recording medium. This is the first time that hig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdb77ac8b7bef80dc98d908acdd95492
https://arrow.tudublin.ie/context/cieoart/article/1112/viewcontent/Analog_holographic_wavefront_sensor_for.pdf
https://arrow.tudublin.ie/context/cieoart/article/1112/viewcontent/Analog_holographic_wavefront_sensor_for.pdf
Autor:
Megan V. Doble, Henriëtte J. Rozeboom, Misun Lee, Paul C. J. Kamer, Lorenz Obrecht, Emma Branigan, Henk-Jan Joosten, James H. Naismith, Amanda G. Jarvis, Dick B. Janssen
Publikováno v:
Doble, M V, Obrecht, L, Joosten, H, Lee, M, Rozeboom, H J, Branigan, E, Naismith, J H, Janssen, D B, Jarvis, A G & Kamer, P C J 2021, ' Engineering Thermostability in Artificial Metalloenzymes to Increase Catalytic Activity ', ACS Catalysis, vol. 11, no. 6, pp. 3620-3627 . https://doi.org/10.1021/acscatal.0c05413
ACS Catalysis, 11(6), 3620-3627. AMER CHEMICAL SOC
ACS Catalysis, 11(6), 3620-3627. AMER CHEMICAL SOC
Protein engineering has shown widespread use in improving the industrial application of enzymes and broadening the conditions they are able to operate under by increasing their thermostability and solvent tolerance. Here, we show that protein enginee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::680ec28cfab832923c74a3b9fae466ec
https://hdl.handle.net/11370/2eed633d-e6b2-45b7-a61b-adf53bca77f6
https://hdl.handle.net/11370/2eed633d-e6b2-45b7-a61b-adf53bca77f6
Publikováno v:
Conference Papers
The analog holographic wavefront sensor (AHWFS) is a simple and robust solution to wavefront sensing in turbulent environments. Here, the ability of a photopolymer-based AHWFS to detect refractively generated spherical aberration is modelled and veri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80a31ceeaa63460a00b2a9eaed86353e
https://doi.org/10.1364/aoa.2022.of2b.4
https://doi.org/10.1364/aoa.2022.of2b.4
Publikováno v:
Conference Papers
The fabrication of an analog holographic wavefront sensor, capable of detecting the low order defocus aberration, was achieved in an acrylamide-based photopolymer. While other implementations of holographic wavefront sensors have been carried out dig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba0d15033656c03c2db9928fd4128e2d
https://doi.org/10.1117/12.2599912
https://doi.org/10.1117/12.2599912
Autor:
Ulrike Kühbacher, Irene Gallina, Julio C Y Liu, Yoshiaki Azuma, Nicolai B. Larsen, Claire Guérillon, Nikoline Borgermann, Niels Mailand, Ronald T. Hay, Emma Branigan, Leena Ackermann, Dimitriya H Garvanska, Ivo A. Hendriks, Michael L. Nielsen, Peter Haahr, Julien P. Duxin
Publikováno v:
Liu, J C Y, Kühbacher, U, Larsen, N B, Borgermann, N, Garvanska, D H, Hendriks, I A, Ackermann, L, Haahr, P, Gallina, I, Guérillon, C, Branigan, E, Hay, R T, Azuma, Y, Nielsen, M L, Duxin, J P & Mailand, N 2021, ' Mechanism and function of DNA replication-independent DNA-protein crosslink repair via the SUMO-RNF4 pathway ', E M B O Journal, vol. 40, e107413 . https://doi.org/10.15252/embj.2020107413
The EMBO Journal
The EMBO Journal
DNA‐protein crosslinks (DPCs) obstruct essential DNA transactions, posing a serious threat to genome stability and functionality. DPCs are proteolytically processed in a ubiquitin‐ and DNA replication‐dependent manner by SPRTN and the proteasom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06fd624e33a326d63e7e57078ba37ff6
https://curis.ku.dk/ws/files/280729418/embj.2020107413.pdf
https://curis.ku.dk/ws/files/280729418/embj.2020107413.pdf
Autor:
Emma Branigan, Ronald T. Hay, Magda Liczmanska, Lindsay Davidson, Barbara Mojsa, Michael H. Tatham
Publikováno v:
bioRxiv
To determine the role of SUMO modification in the maintenance of pluripotent stem cells we used ML792, a potent and selective inhibitor of SUMO Activating Enzyme. Treatment of human induced pluripotent stem cells with ML792 initiated changes associat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5436c3b0086cc43af5cd96eab98152d5
https://doi.org/10.1101/2020.12.22.423944
https://doi.org/10.1101/2020.12.22.423944
Publikováno v:
Cell Chemical Biology
Summary Activity-based protein profiling is an invaluable technique for studying enzyme biology and facilitating the development of therapeutics. Ubiquitin E3 ligases (E3s) are one of the largest enzyme families and regulate a host of (patho)physiolo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcfee5457efb0cb23f3ece8874d77435
https://eprints.gla.ac.uk/245468/1/245468.pdf
https://eprints.gla.ac.uk/245468/1/245468.pdf
Publikováno v:
Methods in enzymology. 618
Posttranslational modification with small ubiquitin-like modifier (SUMO) plays an important role in many biological processes. SUMO-targeted ubiquitin E3 ligases (STUbLs) are part of the really interesting new gene (RING)-type family of ubiquitin E3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::79ce08d20e559f02ed1ff3b6950adfcf
https://pubmed.ncbi.nlm.nih.gov/30850055
https://pubmed.ncbi.nlm.nih.gov/30850055