Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Emma Baston"'
Autor:
R. Martinez Hague, Fiona Chester, Jane Harper, S. Griffin, Angharad Lloyd, Emma Baston, R. Mulvaney, Annelise Vuidepot, K. Smith, S. Harper, K. Wiederhold, A.R. Stacey, Andrew Alexander Knox, S. Malla, K.L. Lowe, C.H. Coles, Z. Donnellan, Samantha Paston, Joseph Dukes, Bent K. Jakobsen, R.A. Robinson, M. Aleksic, A. Walker, Michelle L. McCully
Publikováno v:
The Journal of Immunology. 204:1943-1953
The molecular rules driving TCR cross-reactivity are poorly understood and, consequently, it is unclear the extent to which TCRs targeting the same Ag recognize the same off-target peptides. We determined TCR–peptide–HLA crystal structures and, u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25b03e627be240f30ea60a4a4dabb09d
https://doi.org/10.4049/jimmunol.1900915
https://doi.org/10.4049/jimmunol.1900915
Autor:
Namir J. Hassan, Joseph Dukes, Andrew M.F. Johnson, Annelise Vuidepot, Jane Harper, Brian Cameron, Emma Baston, Peter Eamon Molloy, Giovanna Bossi, C. Coughlin, Nathaniel Liddy, Malkit Sami, Tara Mahon, Bent K. Jakobsen, A. Powesland, Samantha Paston, L. Holt
Publikováno v:
European Journal of Cancer. 92:S15-S16
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a6a278856cd8a8436e2450b561ad3e96
https://doi.org/10.1016/j.ejca.2018.01.039
https://doi.org/10.1016/j.ejca.2018.01.039
Autor:
Emma Baston, Jyoti Shah
Publikováno v:
Cancer Nursing Practice. 12:32-35
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4464e186783a89e3a59abd6f37b5a03b
https://doi.org/10.7748/cnp2013.03.12.2.32.e933
https://doi.org/10.7748/cnp2013.03.12.2.32.e933
Autor:
Jessie Gavarret, Katherine Adams, Jane Harper, Bent K. Jakobsen, Yi Li, Frayne Bianchi, Emma Baston, Michael Kalos, Penio Todorov, Malkit Sami, Steve M. Dunn, Emma Gostick, Nikolai Lissin, David Price, Rebecca Dennis, Peter Eamon Molloy, Samantha Paston, Gabriela Plesa, Kristin Ladell, Giovanna Bossi, Namir J. Hassan, Deborah H. Sutton, Naomi Harwood, Annelise Vuidepot, Carl H. June, Nicholas J. Pumphrey, Nathaniel Liddy, Yvonne McGrath, Brian Cameron, Daniel Williams, Andrew K. Sewell, Tara Mahon, Rebecca Ashfield, Anna Lissina, Andrew M.F. Johnson
Publikováno v:
Nature Medicine. 18:980-987
T cell immunity can potentially eradicate malignant cells and lead to clinical remission in a minority of patients with cancer. In the majority of these individuals, however, there is a failure of the specific T cell receptor (TCR)–mediated immune
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::505ae55c5e09e496a47351e2c4c0a005
https://doi.org/10.1038/nm.2764
https://doi.org/10.1038/nm.2764
Autor:
Ruth Moysey, Jonathan M. Boulter, Pierre J. Rizkallah, Penio Todorov, Emma Baston, Annelise Vuidepot, Peter Eamon Molloy, Malkit Sami, Feng Gao, Bent K. Jakobsen, Yi Li, Steve M. Dunn
Publikováno v:
Protein Engineering, Design and Selection. 20:397-403
Naturally selected T-cell receptors (TCRs) are characterised by low binding affinities, typically in the range 1-100 microM. Crystal structures of syngeneic TCRs bound to peptide major histocompatibility complex (pMHC) antigens exhibit a conserved mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::239e97223dc72501c966384c3e501297
https://doi.org/10.1093/protein/gzm033
https://doi.org/10.1093/protein/gzm033
Autor:
Emma Gostick, David Price, Rebecca Ashfield, Joanna E. Brewer, Marco A. Purbhoo, Brendan J. Classon, Bruno Laugel, Bent K. Jakobsen, Brian Cameron, Deborah H. Sutton, Anita Milicic, Yi Li, Andrew K. Sewell, Ruth Moysey, Emma Baston, Nathaniel Liddy, Giovanna Bossi, Alan D. Bennett
Publikováno v:
Molecular Cancer Therapeutics. 6:2081-2091
Tumor-associated human telomerase reverse transcriptase (hTERT) is expressed in >85% of human tumors but not in most normal cells. As a result, this antigen has received considerable attention from those interested in cancer immunotherapy. Specifical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f092980eb1fa31069d763c01eacd2f17
https://doi.org/10.1158/1535-7163.mct-07-0092
https://doi.org/10.1158/1535-7163.mct-07-0092
Autor:
Marine C C Raman, Pierre J Rizkallah, Ruth Simmons, Zoe Donnellan, Joseph Dukes, Giovanna Bossi, Gabrielle S Le Provost, Penio Todorov, Emma Baston, Emma Hickman, Tara Mahon, Namir Hassan, Annelise Vuidepot, Malkit Sami, David K Cole, Bent K. Jakobsen
Publikováno v:
Scientific Reports
Natural T-cell responses generally lack the potency to eradicate cancer. Enhanced affinity T-cell receptors (TCRs) provide an ideal approach to target cancer cells, with emerging clinical data showing significant promise. Nevertheless, the risk of of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::d72496433db148cb0f21ee07e265580f
https://pubmed.ncbi.nlm.nih.gov/26758806
https://pubmed.ncbi.nlm.nih.gov/26758806
Autor:
Jansen P. Jacob, Annelise Vuidepot, Bent K. Jakobsen, Tara Mahon, Nathaniel Liddy, Yi Li, Jonathan M. Boulter, Peter Eamon Molloy, Emma Baston, Ruth Moysey, Steven M. Dunn
Publikováno v:
Nature Biotechnology. 23:349-354
Peptides derived from almost all proteins, including disease-associated proteins, can be presented on the cell surface as peptide-human leukocyte antigen (pHLA) complexes. T cells specifically recognize pHLA with their clonally rearranged T-cell rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a675b2de0e14608120bf282264c21382
https://doi.org/10.1038/nbt1070
https://doi.org/10.1038/nbt1070
Autor:
Nathaniel Liddy, Alex Powlesland, Joseph Dukes, Lucie Bouard, Malkit Sami, Emma Baston, Jessie Gavarret, Annelise Vuidepot, Andrew D. Johnson, Sarah K. Bailey, Jane Harper, Tara Mahon, Frayne Bianchi, Samantha Paston, Peter L. Molloy, Namir J. Hassan, Bent K. Jakobsen, Martin Ebner, Penio Todorov, Yvonne McGrath, Andrew Ramsay Knox, Brian Cameron, Giovanna Bossi, Fiona Chester
Publikováno v:
Cancer Research. 76:4872-4872
Immunotherapeutic strategies that drive activation of cytotoxic T cells possess significant potential to eradicate tumours. Whereas monoclonal antibodies are restricted to targeting secreted or cell surface proteins, T cell receptors (TCRs) are able
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7504686c5a0cd8abaa387aa32ddb43b8
https://doi.org/10.1158/1538-7445.am2016-4872
https://doi.org/10.1158/1538-7445.am2016-4872
Autor:
Tara Mahon, Joseph Dukes, Malkit Sami, Annelise Vuidepot, Bent K. Jakobsen, Caroline Boudousquie, Samantha Paston, Jane Harper, Emma Baston, Nathaniel Liddy, Rupert Kenefeck, Giovanna Bossi, Namir J. Hassan, Peter L. Molloy, Brian Cameron
Publikováno v:
Cancer Research. 76:4873-4873
Immunotherapy strategies that are able to induce T cell infiltration into tumors and activate a cytotoxic T cell response have the potential to destroy the tumor. Although T cells can mediate clearance of a tumor, thymic selection and the suppressive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::39a9174ec562e6809db504059f90f1e0
https://doi.org/10.1158/1538-7445.am2016-4873
https://doi.org/10.1158/1538-7445.am2016-4873