Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Emma Barroso"'
Autor:
Meijian Zhang, Emma Barroso, Lucía Peña, Patricia Rada, Ángela M. Valverde, Walter Wahli, Xavier Palomer, Manuel Vázquez-Carrera
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 179, Iss , Pp 117303- (2024)
The role of peroxisome proliferator-activated receptor (PPAR)β/δ in hepatic fibrosis remains a subject of debate. Here, we examined the effects of a PPARβ/δ agonist on the pathogenesis of liver fibrosis and the activation of hepatic stellate cell
Externí odkaz:
https://doaj.org/article/bd3f461a588d498c847ef3d9ba500e5e
Autor:
Mona Peyman, Anna Babin-Ebell, Rosalía Rodríguez-Rodríguez, Matilde Rigon, David Aguilar-Recarte, Joan Villarroya, Anna Planavila, Francesc Villarroya, Xavier Palomer, Emma Barroso, Manuel Vázquez-Carrera
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-11 (2024)
Abstract Background Endoplasmic reticulum (ER) stress-mediated increases in the hepatic levels of the very low-density lipoprotein (VLDL) receptor (VLDLR) promote hepatic steatosis by increasing the delivery of triglyceride-rich lipoproteins to the l
Externí odkaz:
https://doaj.org/article/aa50fcc0fdab48139a2c97688557bd98
Autor:
Emma Barroso, Marta Díaz, Ana Cristina Reguera, Mona Peyman, Jesús Balsinde, Javier Jurado-Aguilar, Meijian Zhang, Adel Rostami, Xavier Palomer, Lourdes Ibáñez, Manuel Vázquez-Carrera
Publikováno v:
Cell Communication and Signaling, Vol 21, Iss 1, Pp 1-13 (2023)
Abstract Background The placentas from newborns that are small for gestational age (SGA; birth weight
Externí odkaz:
https://doaj.org/article/0dde09ae81aa407db201bf013672fee5
Autor:
Mona Peyman, Emma Barroso, Andreea L. Turcu, Francesc Estrany, Jr., Dáire Smith, Javier Jurado-Aguilar, Patricia Rada, Christophe Morisseau, Bruce D. Hammock, Ángela M. Valverde, Xavier Palomer, Carles Galdeano, Santiago Vázquez, Manuel Vázquez-Carrera
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 168, Iss , Pp 115667- (2023)
Soluble epoxide hydrolase (sEH) is a drug target with the potential for therapeutic utility in the areas of inflammation, neurodegenerative disease, chronic pain, and diabetes, among others. Proteolysis-targeting chimeras (PROTACs) molecules offer ne
Externí odkaz:
https://doaj.org/article/5a58d1a50ea04ea4b20efc84ec133208
Autor:
Meijian Zhang, Emma Barroso, Maria Ruart, Lucía Peña, Mona Peyman, David Aguilar-Recarte, Marta Montori-Grau, Patricia Rada, Clara Cugat, Carla Montironi, Mohammad Zarei, Javier Jurado-Aguilar, Antoni Camins, Jesús Balsinde, Ángela M. Valverde, Walter Wahli, Xavier Palomer, Manuel Vázquez-Carrera
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 167, Iss , Pp 115623- (2023)
Elafibranor is a dual peroxisome proliferator-activated receptor (PPAR)α and β/δ agonist that has reached a phase III clinical trial for the treatment of metabolic dysfunction-associated steatotic liver disease (MASLD). Here, we examined the effec
Externí odkaz:
https://doaj.org/article/482a0be0b5064142a7d350a00b86da03
Autor:
Meijian Zhang, Andrea Bagán, Donna Martínez, Emma Barroso, Xavier Palomer, Santiago Vázquez, Carmen Escolano, Manuel Vázquez-Carrera
Publikováno v:
Molecules, Vol 28, Iss 14, p 5468 (2023)
Targeting growth differentiation factor 15 (GDF15) is a recent strategy for the treatment of obesity and type 2 diabetes mellitus (T2DM). Here, we designed, synthesized, and pharmacologically evaluated in vitro a novel series of AMPK activators to up
Externí odkaz:
https://doaj.org/article/ed40fcf35d894d019b9ccc79b82ff181
Autor:
Emma Barroso, Rosalía Rodríguez-Rodríguez, Mohammad Zarei, Javier Pizarro-Degado, Anna Planavila, Xavier Palomer, Francesc Villarroya, Manuel Vázquez-Carrera
Publikováno v:
Cell Communication and Signaling, Vol 18, Iss 1, Pp 1-13 (2020)
Abstract Background Deficiency of mitochondrial sirtuin 3 (SIRT3), a NAD+-dependent protein deacetylase that maintains redox status and lipid homeostasis, contributes to hepatic steatosis. In this study, we investigated additional mechanisms that mig
Externí odkaz:
https://doaj.org/article/1e71b226e6b349409edc0fa281f69201
Autor:
David Aguilar-Recarte, Emma Barroso, Anna Gumà, Javier Pizarro-Delgado, Lucía Peña, Maria Ruart, Xavier Palomer, Walter Wahli, Manuel Vázquez-Carrera
Publikováno v:
Cell Reports, Vol 36, Iss 6, Pp 109501- (2021)
Summary: Peroxisome proliferator-activated receptor β/δ (PPARβ/δ) activates AMP-activated protein kinase (AMPK) and plays a crucial role in glucose and lipid metabolism. Here, we examine whether PPARβ/δ activation effects depend on growth diffe
Externí odkaz:
https://doaj.org/article/b6f0fb8048d340e8be15dc85700ffd26
Hepatic regulation of VLDL receptor by PPARβ/δ and FGF21 modulates non-alcoholic fatty liver disease
Autor:
Mohammad Zarei, Emma Barroso, Xavier Palomer, Jianli Dai, Patricia Rada, Tania Quesada-López, Joan Carles Escolà-Gil, Lidia Cedó, Mohammad Reza Zali, Mahsa Molaei, Reza Dabiri, Santiago Vázquez, Eugènia Pujol, Ángela M. Valverde, Francesc Villarroya, Yong Liu, Walter Wahli, Manuel Vázquez-Carrera
Publikováno v:
Molecular Metabolism, Vol 8, Iss , Pp 117-131 (2018)
Objective: The very low-density lipoprotein receptor (VLDLR) plays an important role in the development of hepatic steatosis. In this study, we investigated the role of Peroxisome Proliferator-Activated Receptor (PPAR)β/δ and fibroblast growth fact
Externí odkaz:
https://doaj.org/article/baf2dc9394c64f748472e1cdb91dd1a9
Autor:
Victor García-Torra, Amanda Cano, Marta Espina, Miren Ettcheto, Antoni Camins, Emma Barroso, Manel Vazquez-Carrera, Maria Luisa García, Elena Sánchez-López, Eliana B. Souto
Publikováno v:
Toxics, Vol 9, Iss 8, p 195 (2021)
Metal nanoparticles have been extensively investigated for different types of pharmaceutical applications. However, their use has raised some concerns about their toxicity involving the increase of reactive oxygen species causing cellular apoptosis.
Externí odkaz:
https://doaj.org/article/366333d264fa431a88b9dff119f267b3