MiR-422a promotes loco-regional recurrence by targeting NT5E/CD73 in head and neck squamous cell carcinoma

Autor: David Meyronet, Emma Armandy, Priscillia Battiston-Montagne, Alain Jung, Sébastien Guihard, Julien Carras, Sonia Ledrappier, Marc Aubry, Ruth Rimokh, Sylvain Ferrandon, Delphine Poncet, Jean-Philippe Foy, Claire Rodriguez-Lafrasse, Pierre Saintigny, Nathalie Bonnin

Publikováno v: Oncotarget
Oncotarget, 2016, 7 (28), pp.44023-44038. ⟨10.18632/oncotarget.9829⟩
Oncotarget, Impact journals, 2016, 7 (28), pp.44023-44038. ⟨10.18632/oncotarget.9829⟩

At the time of diagnosis, 60% of patients with head and neck squamous cell carcinoma (HNSCC) present tumors in an advanced stage (III-IV) of disease and 80% will relapse within the first two years post-treatment, due to their frequent radio(chemo)res

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::783e2e9c6790e2657fda18a031dd3d23
https://hal.science/hal-01376219

In Vitro Radiosensitizing Effects of Ultrasmall Gadolinium Based Particles on Tumour Cells

Autor: C Roulin, Muriel Barberi-Heyob, Emma Armandy, Anna Mignot, Claire Rodriguez-Lafrasse, Pierre Mowat, L Humbert, Pascal Perriat, Wael Rima, Marie-Thérèse Aloy, Marie Dutreix, G. Le Duc, Denise Bechet, Stéphane Roux, François Lux, S Huger, Olivier Tillement

Publikováno v: Journal of Nanoscience and Nanotechnology. 11:7833-7839

Since radiotherapy is widely used in cancer treatment, it is essential to develop strategies which lower the irradiation burden while increasing efficacy and become efficient even in radio resistant tumors. Our new strategy is relying on the developm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eaa1ccae3651a0daf7cbcde3c8ec1290
https://doi.org/10.1166/jnn.2011.4725

Combining ultrasmall gadolinium-based nanoparticles with photon irradiation overcomes radioresistance of head and neck squamous cell carcinoma

Autor: Olivier Tillement, Marc Janier, Pierre Mowat, François Lux, Claire Billotey, Nicolas Magné, Claire Rodriguez-Lafrasse, Imen Miladi, David Kryza, Marie-Thérèse Aloy, Emma Armandy

Publikováno v: Nanomedicine
Nanomedicine, Future Medicine, 2015, 11 (1), pp.147-157. 〈10.1016/j.nano.2014.06.013〉
Nanomedicine, Future Medicine, 2015, 11 (1), pp.147-157. ⟨10.1016/j.nano.2014.06.013⟩

International audience; Gadolinium based nanoparticles (GBNs, diameter 2.9±0.2nm), have promising biodistribution properties for theranostic use in-vivo. We aimed at demonstrating the radiosensitizing effect of these GBNs in experimental radioresist

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b30e39e671e7c7df48537eb2185750d7
https://hal.archives-ouvertes.fr/hal-01053787

Internalization pathways into cancer cells of gadolinium-based radiosensitizing nanoparticles

Autor: Marie Thérèse Aloy, Stéphane Roux, Thierry Epicier, Annie Rivoire, Béatrice Burdin, Isabelle Anselme-Bertrand, Jérémie Pourchez, Olivier Tillement, Claire Rodriguez-Lafrasse, Annie Malchere, Gustavo B. Alcantara, Pascal Perriat, Christelle Boulé, Emma Armandy, François Lux, Michèle Cottier, Lucile Joly-Pottuz, Wael Rima, Pierre Mowat, Lucie Sancey

Publikováno v: Biomaterials
Biomaterials, Elsevier, 2013, 34, pp.181-195. ⟨10.1016/j.biomaterials.2012.09.029⟩
Biomaterials, Elsevier, 2013, 34, pp.181-195. 〈10.1016/j.biomaterials.2012.09.029〉

International audience; Over the last few decades, nanoparticles have been studied in theranostic field with the objective of exhibiting a long circulation time through the body coupled to major accumulation in tumor tissues, rapid elimination, thera

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffc7f7151cef3ab76ad40cebb1fd409d
https://hal.archives-ouvertes.fr/hal-00757773

Heat shock protein 27 as a new therapeutic target for radiation sensitization of head and neck squamous cell carcinoma

Autor: Martin E. Gleave, O. Chapet, Emmanuel Watkin, Elie Hadchity, Christian Paulin, Emma Armandy, Claire Rodriguez-Lafrasse, Robert Rousson, Marie-Thérèse Aloy

Publikováno v: Molecular Therapy
Molecular Therapy, Cell Press, 2009, 17 (8), pp.1387-94. ⟨10.1038/mt.2009.90⟩

International audience; In a wide range of human cancers, increased levels of heat shock protein 27 (Hsp27) are closely associated with tumorigenesis, metastasis, resistance to anticancer therapeutics, and thus poor prognosis. In this study, we evalu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7248475ab59556b3bb501db39c8a0037
https://hal.archives-ouvertes.fr/hal-00466410