Carbonyl reductase 1 amplifies glucocorticoid action in adipose tissue and impairs glucose tolerance in lean mice

Autor: Rachel M.B. Bell, Elisa Villalobos, Mark Nixon, Allende Miguelez-Crespo, Lee Murphy, Angie Fawkes, Audrey Coutts, Matthew G.F. Sharp, Martha V. Koerner, Emma Allan, Onno C. Meijer, Renè Houtman, Alex Odermatt, Katharina R. Beck, Scott G. Denham, Patricia Lee, Natalie Z.M. Homer, Brian R. Walker, Ruth A. Morgan

Publikováno v: Molecular Metabolism, Vol 48, Iss , Pp 101225- (2021)

Objective: Carbonyl reductase 1 (Cbr1), a recently discovered contributor to tissue glucocorticoid metabolism converting corticosterone to 20β-dihydrocorticosterone (20β-DHB), is upregulated in adipose tissue of obese humans and mice and may contri

Externí odkaz: https://doaj.org/article/a6432528238548eaaf19f70db5178bdf

Carbonyl reductase 1 amplifies glucocorticoid action in adipose tissue and impairs glucose tolerance in lean mice

Autor: Mark Nixon, Emma Allan, René Houtman, Matthew G.F. Sharp, Onno C. Meijer, Lee Murphy, Allende Miguelez-Crespo, Audrey Coutts, Alex Odermatt, Angie Fawkes, Scott G. Denham, Brian R. Walker, Katharina Beck, Elisa Villalobos, Natalie Z.M. Homer, Ruth Morgan, Patricia Lee, Martha V. Koerner, Rachel M.B. Bell

Publikováno v: Bell, R, Villalobos, E, Nixon, M, Miguelez-Crespo1, A, Murphy, L, Fawkes, A, Coutts, A, Sharp, M G, Koerner, M, Allan, E, Meijer, O C, Houtman, R, Odermatt, A, Beck, K R, Denham, S, Lee, P, Homer, N, Walker, B R & Morgan, R A 2021, ' Carbonyl reductase 1 amplifies glucocorticoid action in adipose tissue and impairs glucose tolerance in lean mice. ', Molecular Metabolism . https://doi.org/10.1016/j.molmet.2021.101225
Molecular Metabolism
MOLECULAR METABOLISM, 48. ELSEVIER
MOLECULAR METABOLISM
Molecular Metabolism, Vol 48, Iss, Pp 101225-(2021)

Objective Carbonyl reductase 1 (Cbr1), a recently discovered contributor to tissue glucocorticoid metabolism converting corticosterone to 20β-dihydrocorticosterone (20β-DHB), is upregulated in adipose tissue of obese humans and mice and may contrib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::737d2b0c9cd27d200cf352c66fe1349e
https://doi.org/10.1016/j.molmet.2021.101225

Interventions to increase follow-up of abnormal cervical cancer screening results: A systematic literature review and meta-analysis.

Autor: Melissa Lopez Varon, Yimin Geng, Bryan M Fellman, Catherine Troisi, Maria E Fernandez, Ruosha Li, Belinda Reininger, Kathleen M Schmeler, Emma Allanson

Publikováno v: PLoS ONE, Vol 19, Iss 2, p e0291931 (2024)

IntroductionEnsuring timely follow-up of abnormal screening results is essential for eliminating cervical cancer.ObjectiveThe purpose of the study was to review single and multicomponent interventions designed to improve follow-up of women with abnor

Externí odkaz: https://doaj.org/article/6f28d3a699374e5da875daf2e764b8ab

Identification and characterisation of the role of cyclooxygenase-2 (COX-2) in cancer stem cell biology: a comparative study

Autor: Hurst, Emma Allan

Cancer is a stem cell disease and populations of cancer stem cells (CSCs) are evident in many cancer types. CSCs exhibit similarities to normal embryonic and adult stem cells: they are able to self-renew and have the potential to give rise to a diver

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______463::32dec8df2058e38dd04b12cc63b687b6
http://hdl.handle.net/1842/28852

0071 Participants’ Perceptions Of Interprofessional Simulation Training In The Uk

Autor: Emma Allan, Nick Murch, Ben Lovell

Publikováno v: Posters Without Presentations.

Background Simulation training (ST) is used increasingly in medical education as an interactive learning tool in a controlled and patient-safe environment. 1 In addition, interprofessional simulation allows better understanding of others’ roles, im

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::94419e8fd6ab67dda7995a2efb4d4f07
https://doi.org/10.1136/bmjstel-2014-000002.97