Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Emma A. Kruglov"'
Autor:
Meenakshisundaram Ananthanarayanam, Fernanda O. Lemos, Fulan Guan, Basile Njei, Emma A. Kruglov, Albert Mennone, André G. Oliveira, Maria de Fátima Leite, Rodrigo M. Florentino, Jianlei Gu, Marcone Loiola dos Santos, Andressa França, Joanna Gibson, Paula T Vidigal, Mateus T. Guerra, Roberta Cristelli Fonseca, Matheus de Castro Fonseca, Antônio Carlos Melo Lima Filho, Jianping Jiang, Hongyu Zhao, Michael H. Nathanson, Cristiano Xavier Lima, Yung-Chi Cheng
Publikováno v:
Gut. 68:1676-1687
Background & objectivesHepatocellular carcinoma (HCC) is the second leading cause of cancer death worldwide. Several types of chronic liver disease predispose to HCC, and several different signalling pathways have been implicated in its pathogenesis,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b481417243432473a8b2750d89666f88
https://doi.org/10.1136/gutjnl-2018-317811
https://doi.org/10.1136/gutjnl-2018-317811
Autor:
Mateus T. Guerra, Pedro Sousa, Michael H. Nathanson, Meenakshisundaram Ananthanarayanan, Jittima Weerachayaphorn, Emma A. Kruglov
Publikováno v:
Biochemical and Biophysical Research Communications. 486:659-664
The type 2 inositol 1,4,5-trisphosphate receptor (IP3R2) is the principal intracellular Ca2+ release channel in hepatocytes, and so is important for bile secretion and other functions. IP3R2 activity is regulated in part by post-translational modific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1baaacc0a48a61e9bed5ce921891998
https://doi.org/10.1016/j.bbrc.2017.03.086
https://doi.org/10.1016/j.bbrc.2017.03.086
Autor:
Maria Olave-Martinez, Melanie A. Hundt, Jittima Weerachayaphorn, Remco Kersten, Tanaporn Khamphaya, Mateus T. Guerra, Marie E. Robert, Paula T Vidigal, Randolph de la Rosa Rodriguez, Masahiro Takeuchi, Satoshi Aoki, Emma A. Kruglov, Jesus M. Banales, Michael H. Nathanson
Publikováno v:
Gut
Background & objectivesAlcoholic hepatitis (AH) is a common but life-threatening disease with limited treatment options. It is thought to result from hepatocellular damage, but the presence of cholestasis worsens prognosis, so we examined whether bil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb61fd5970c3ac389240b517b6f02365
https://doi.org/10.1136/gutjnl-2020-322540
https://doi.org/10.1136/gutjnl-2020-322540
Autor:
Barbara E. Ehrlich, Anton M. Bennett, Michael J. Jurczak, Lily Nguyen, Gerald I. Shulman, Emma A. Kruglov, Michael H. Nathanson, Colleen N. Feriod
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 307:E1057-E1064
Inositol 1,4,5-trisphosphate receptor type II (InsP3R-II) is the most prevalent isoform of the InsP3R in hepatocytes and is concentrated under the canalicular membrane, where it plays an important role in bile secretion. We hypothesized that altered
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dec36dff3704eeceeec2e5ddc9382c0
https://doi.org/10.1152/ajpendo.00236.2014
https://doi.org/10.1152/ajpendo.00236.2014
Autor:
Emma A. Kruglov, Jin Yu, Jonathan A. Dranoff, Gaurav Arora, Paulo Renato A.V. Correa, Michael H. Nathanson
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 292:G975-G982
Progressive liver fibrosis (with the resultant cirrhosis) is the primary cause of chronic liver failure. Hepatic stellate cells (HSCs) are critically important mediators of liver fibrosis. In the healthy liver, HSCs are quiescent lipid-storing cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8755a14e5cab4028c9646644db0d913f
https://doi.org/10.1152/ajpgi.00401.2006
https://doi.org/10.1152/ajpgi.00401.2006
Autor:
Oscar Bruna-Romero, Emma A. Kruglov, Frank J. Giordano, Dawidson Assis Gomes, Michele Angela Rodrigues, Erick Hernandez, M. Fatima Leite, Michael H. Nathanson, Jonathan A. Dranoff, Mateus T. Guerra
Publikováno v:
Journal of Biological Chemistry. 282:10057-10067
Cytosolic Ca(2+) is a versatile second messenger that can regulate multiple cellular processes simultaneously. This is accomplished in part through Ca(2+) waves and other spatial patterns of Ca(2+) signals. To investigate the mechanism responsible fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88cc4918a0d22ef7e8a7530404721064
https://doi.org/10.1074/jbc.m700746200
https://doi.org/10.1074/jbc.m700746200
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 290:G765-G771
Portal fibroblasts (PF) are fibrogenic liver cells distinct from hepatic stellate cells (HSC). Recent evidence suggests that PF may be important mediators of biliary fibrosis and cirrhosis. The cytokine monocyte chemoattractant protein-1 (MCP-1)/CCL2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c3e3cf4872ab4c8777d996e88184a05
https://doi.org/10.1152/ajpgi.00308.2005
https://doi.org/10.1152/ajpgi.00308.2005
Autor:
Michael H. Nathanson, Noritaka Minagawa, Gregory J. Gores, Jonathan A. Dranoff, Marie E. Robert, Emma A. Kruglov
Publikováno v:
Journal of Biological Chemistry. 280:33637-33644
Apoptosis contributes to the regulation of cell growth and regeneration and to the development of neoplasia. Mcl-1 is an anti-apoptotic protein that is particularly important for the development of hematological and biliary malignancies, but the mech
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1dd48de09afc46c3d231d370323e99e
https://doi.org/10.1074/jbc.m503210200
https://doi.org/10.1074/jbc.m503210200
Autor:
Jonathan A. Dranoff, Herbert Zimmermann, Norbert Braun, Jean Sévigny, Simon C. Robson, Emma A. Kruglov
Publikováno v:
Hepatology. 36:1135-1144
Extracellular nucleotides regulate diverse biological functions and are important in the regulation of liver metabolism, hepatic blood flow, and bile secretion. Ecto-nucleoside triphosphate diphosphohydrolases (NTPDases) hydrolyze extracellular nucle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::68f92f176d4d185c2fda7a57963080f9
https://doi.org/10.1053/jhep.2002.36823
https://doi.org/10.1053/jhep.2002.36823
Publikováno v:
Journal of Investigative Medicine. 50:179-184
Introduction One of the major advances in liver research in the past decade was the ability to isolate distinct liver cell populations. Although there are established methods of isolating hepatocytes, cholangiocytes, and stellate cells, before this s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::338ffcaf8d29b459f7b3428d80a59f80
https://doi.org/10.2310/6650.2002.33431
https://doi.org/10.2310/6650.2002.33431