Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Emma A Fairhall"'
Autor:
Emma A Fairhall, Michelle A Charles, Philip M E Probert, Karen Wallace, Jennifer Gibb, Chandni Ravindan, Martin Soloman, Matthew C Wright
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0150959 (2016)
The proliferative B-13 pancreatic cell line is unique in its ability to generate functional hepatocyte-like (B-13/H) cells in response to exposure to glucocorticoid. In these studies, quantitatively comparable hepatic levels of liver-specific and liv
Externí odkaz:
https://doaj.org/article/ed6f29f4fcd2429e873bb0e917e6cdbe
Autor:
Fanny Knöspel, Emma A. Fairhall, Philip M. E. Probert, Katrin Zeilinger, S. Tröbs, A. Stroux, M. Richter, Stefan A. Hoffmann, Fiona Oakley, Matthew C. Wright
Publikováno v:
Toxicology Research. 5:278-290
The rat pancreatic progenitor cell line B-13 is of interest for research on drug metabolism and toxicity since the cells trans-differentiate into functional hepatocyte-like cells (B-13/H) when treated with glucocorticoids. In this study we investigat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e38b854d423752a071d17874db8d33f5
https://doi.org/10.1039/c5tx00187k
https://doi.org/10.1039/c5tx00187k
Autor:
Matthew C. Wright, Emma A. Fairhall, Ibrahim Ibrahim, George E.N. Kass, Anne F. Lakey, Tarek M. Abdelghany, Alistair C. Leitch, David Tosh, Colin H Wilson
Publikováno v:
Biochemical and biophysical research communications. 503(3)
The pancreas and liver are closely related developmentally and trans-differentiation of cells from one tissue into the cells of the other has been documented to occur after injury or exposure to selected growth factors or glucocorticoid hormones. To
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e12e407b6438ad9557adb0d36a0d693a
https://pubmed.ncbi.nlm.nih.gov/30057318
https://pubmed.ncbi.nlm.nih.gov/30057318
Autor:
Gabriella Richardson, Carol De Santis, Anne F. Lakey, Emma A. Fairhall, Philip M. E. Probert, Alistair C. Leitch, Matthew C. Wright
Publikováno v:
Differentiation; research in biological diversity. 102
The rodent pancreatic AR42J-B13 (B-13) cell line differentiates into non-replicative hepatocyte-like cells in response to glucocorticoid mediated via the glucocorticoid receptor (GR). The aims of this study were to identify a human cell line that res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::023a89e9826b406120a6c934e700b2e3
https://pubmed.ncbi.nlm.nih.gov/29857331
https://pubmed.ncbi.nlm.nih.gov/29857331
Autor:
Andrew A. Axon, Paul A. Jowsey, Karen Wallace, Matthew C. Wright, Fouzeyyah Alsaeedi, Emma A. Fairhall, Stephanie K. Meyer, Fiona Oakley, Philip M. E. Probert, Michelle Charles, Peter G. Blain
Publikováno v:
Toxicology Research. 4:203-222
The B-13 cell is a readily expandable rat pancreatic acinar-like cell that differentiates on simple plastic culture substrata into replicatively-senescent hepatocyte-like (B-13/H) cells in response to glucocorticoid exposure. B-13/H cells express a v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::951d1999c80f1b18484033b32036e3da
https://doi.org/10.1039/c4tx00214h
https://doi.org/10.1039/c4tx00214h
Autor:
Matthew C. Wright, Keith A. Charlton, James Shaw, Emma A. Fairhall, Guo Cai Huang, Karen Wallace, Sid C. Wright, Steven A. White, Alastair D. Burt
Publikováno v:
Toxicol. Res.
Reduction in the use of animals in toxicology is an important goal despite the continued need to assess drug and chemical safety in man. However, a limitation to in vitro screening for drug and chemical toxicity is the lack of available human hepatoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc5fae316b57c8666a92b7f59d1af705
https://doi.org/10.1039/c2tx20061a
https://doi.org/10.1039/c2tx20061a
Publikováno v:
Journal of Cell Science. 124:405-413
Elevated glucocorticoid levels result in the transdifferentiation of pancreatic acinar cells into hepatocytes through a process that requires a transient repression of WNT signalling upstream of the induction of C/EBP-β. However, the mechanism by wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4258b0a2ae972bfba37a6c74beedb7f
https://doi.org/10.1242/jcs.077503
https://doi.org/10.1242/jcs.077503
Publikováno v:
Toxicology. 278:277-287
Hepatocytes are the preparation of choice for Toxicological research in vitro. However, despite the fact that hepatocytes proliferate in vivo during liver regeneration, they are resistant to proliferation in vitro, do not tolerate sub-culture and ten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edae07cb88bbf24913bdd64727441e4b
https://doi.org/10.1016/j.tox.2010.05.008
https://doi.org/10.1016/j.tox.2010.05.008
Publikováno v:
Zeitschrift für Gastroenterologie. 52
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e57402cc5bb41392a6e77a40e1eb72a
https://doi.org/10.1055/s-0033-1360953
https://doi.org/10.1055/s-0033-1360953
Autor:
Matthew C. Wright, Emma A. Fairhall, Keith A. Charlton, Michelle Charles, Stefan A. Hoffmann, M. Richter, Claire Schwab, Christine J. Harrison, Katrin Zeilinger, Karen Wallace
Publikováno v:
Toxicology Research
The rat pancreatic “B-13” acinar cell is a stable progenitor cell line that differentiates into hepatocyte-like cells (B-13/H cells) in 2D un-coated plastic culture with simple culture media in response to glucocorticoid exposure. Examination of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb53bf61ce18a8f9153da79fcd1b3e82