Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Emma, McCullagh"'
Autor:
Jason Pinkstaff, Emma McCullagh, Anita Grover, Andrew C. Melton, Anu Cherukuri, Jill CM Wait, Annalisa Nguyen, Mark T. Butt, Jami L. Trombley, Randall P. Reed, Eric.L. Adams, Robert B. Boyd, Sundeep Chandra, Joshua Henshaw, Charles A. O’Neill, Eric Zanelli, Joseph Kovalchin
Publikováno v:
Toxicology Reports, Vol 10, Iss , Pp 357-366 (2023)
Mucopolysaccharidosis Type IIIB (MPS IIIB) is an ultrarare, fatal pediatric disease with no approved therapy. It is caused by mutations in the gene encoding for lysosomal enzyme alpha-N-acetylglucosaminidase (NAGLU). Tralesinidase alfa (TA) is a fusi
Externí odkaz:
https://doaj.org/article/cfbd12d153c245b5adea0f11f64be6c8
Autor:
Martin T. Egeland, Marta M. Tarczyluk-Wells, Melissa M. Asmar, Evan G. Adintori, Roger Lawrence, Elizabeth M. Snella, Jackie K. Jens, Brett E. Crawford, Jill C. M. Wait, Emma McCullagh, Jason Pinkstaff, Jonathan D. Cooper, N. Matthew Ellinwood
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-16 (2020)
Abstract Mucopolysaccharidosis type IIIB (MPS IIIB; Sanfilippo syndrome B) is an autosomal recessive lysosomal storage disorder caused by the deficiency of alpha-N-acetylglucosaminidase activity, leading to increased levels of nondegraded heparan sul
Externí odkaz:
https://doaj.org/article/5500192f556445fb9991fe7f6927c244
Autor:
Catlyn Cavender, Linley Mangini, Jeremy L Van Vleet, Carley Corado, Emma McCullagh, Heather L Gray-Edwards, Douglas R Martin, Brett E Crawford, Roger Lawrence
Publikováno v:
PLoS ONE, Vol 15, Iss 12, p e0243006 (2020)
β-hexosaminidase is an enzyme responsible for the degradation of gangliosides, glycans, and other glycoconjugates containing β-linked hexosamines that enter the lysosome. GM2 gangliosidoses, such as Tay-Sachs and Sandhoff, are lysosomal storage dis
Externí odkaz:
https://doaj.org/article/107bc3d828c440d4a76bc745f2d101e6
Autor:
Marta M. Tarczyluk-Wells, Evan G. Adintori, N. Matthew Ellinwood, Jonathan D. Cooper, Martin T. Egeland, Melissa M. Asmar, Elizabeth M. Snella, Emma McCullagh, Brett E. Crawford, Jackie K. Jens, Jill C.M. Wait, Roger Lawrence, Jason Pinkstaff
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-16 (2020)
Scientific Reports
Scientific Reports
Mucopolysaccharidosis type IIIB (MPS IIIB; Sanfilippo syndrome B) is an autosomal recessive lysosomal storage disorder caused by the deficiency of alpha-N-acetylglucosaminidase activity, leading to increased levels of nondegraded heparan sulfate (HS)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57de328579a34710709d49596ec0a756
https://doaj.org/article/5500192f556445fb9991fe7f6927c244
https://doaj.org/article/5500192f556445fb9991fe7f6927c244
Autor:
Aaron S Mendez, Jennifer Alfaro, Marisol A Morales-Soto, Arvin C Dar, Emma McCullagh, Katja Gotthardt, Han Li, Diego Acosta-Alvear, Carmela Sidrauski, Alexei V Korennykh, Sebastian Bernales, Kevan M Shokat, Peter Walter
Publikováno v:
eLife, Vol 4 (2015)
Two ER membrane-resident transmembrane kinases, IRE1 and PERK, function as stress sensors in the unfolded protein response. IRE1 also has an endoribonuclease activity, which initiates a non-conventional mRNA splicing reaction, while PERK phosphorylat
Externí odkaz:
https://doaj.org/article/4bb32bbcaa164101ab39039acd5508e5
Autor:
Emma McCullagh, Linley Mangini, Carley R. Corado, Jeremy L. Van Vleet, Roger Lawrence, Douglas R. Martin, Heather L. Gray-Edwards, Brett E. Crawford, Catlyn Cavender
Publikováno v:
PLoS ONE, Vol 15, Iss 12, p e0243006 (2020)
PLoS ONE
PLoS ONE
β-hexosaminidase is an enzyme responsible for the degradation of gangliosides, glycans, and other glycoconjugates containing β-linked hexosamines that enter the lysosome. GM2 gangliosidoses, such as Tay-Sachs and Sandhoff, are lysosomal storage dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96a0d5396fc4f7f204ee6e0cb2aa0cff
https://doaj.org/article/107bc3d828c440d4a76bc745f2d101e6
https://doaj.org/article/107bc3d828c440d4a76bc745f2d101e6
Autor:
Luz Delgado, Roopa Rai, Shailender Chauhan, Patricio Avila, Dhananjay I. Patel, Glenda Fuentealba, Camila Flores, Kevin P. Quinn, T. V. R. Upendra, Vijay Kumar Sharma, Sarvajit Chakravarty, Anjan Kumar Nayak, Emma McCullagh, Gonzalo Ureta, Ramona Almirez, Brahmam Pujala, Sebastian Bernales, Jennifer Alfaro, David T. Hung, Son Minh Pham, Diana Gaete, Sebastian Belmar, Felipe Pérez de Arce, Stacy Kanno, Claudia Acuña, Anup Barde
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 361:312-321
Although new targeted therapies, such as ibrutinib and idelalisib, have made a large impact on non-Hodgkin's lymphoma (NHL) patients, the disease is often fatal because patients are initially resistant to these targeted therapies, or because they eve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a88d9ba848c5c5372e62f468a36b17ce
https://doi.org/10.1124/jpet.116.238022
https://doi.org/10.1124/jpet.116.238022
Autor:
Michael J. Green, Roopa Rai, Kevin P. Quinn, Ashu Gupta, Jennifer Alfaro, Dhananjay I. Patel, David T. Hung, Stacy Kanno, Nitin Atmaram Randive, Emma McCullagh, Monali Banerjee, Anamika Thakur, Sarvajit Chakravarty, Anjan Kumar Nayak, Anil Agarwal, Ramona Almirez, Sweta Khare, Brahmam Pujala, Rambabu Guguloth, Sebastian Bernales, Sandip Middya, Mohd. Raja, Son Minh Pham, Bharat Uttam Shinde, Felipe Pérez de Arce, Arjun Surya, Patricio Avila
Publikováno v:
ACS Medicinal Chemistry Letters. 7:1161-1166
The aberrant activation of B-cells has been implicated in several types of cancers and hematological disorders. BTK and PI3Kδ are kinases responsible for B-cell signal transduction, and inhibitors of these enzymes have demonstrated clinical benefit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c36968f9bd3299d938b2fbcd47dfe5c0
https://doi.org/10.1021/acsmedchemlett.6b00356
https://doi.org/10.1021/acsmedchemlett.6b00356
Autor:
Jennifer, Alfaro, Felipe, Pérez de Arce, Sebastián, Belmar, Glenda, Fuentealba, Patricio, Avila, Gonzalo, Ureta, Camila, Flores, Claudia, Acuña, Luz, Delgado, Diana, Gaete, Brahmam, Pujala, Anup, Barde, Anjan K, Nayak, T V R, Upendra, Dhananjay, Patel, Shailender, Chauhan, Vijay K, Sharma, Stacy, Kanno, Ramona G, Almirez, David T, Hung, Sarvajit, Chakravarty, Roopa, Rai, Sebastián, Bernales, Kevin P, Quinn, Son M, Pham, Emma, McCullagh
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 361(2)
Although new targeted therapies, such as ibrutinib and idelalisib, have made a large impact on non-Hodgkin's lymphoma (NHL) patients, the disease is often fatal because patients are initially resistant to these targeted therapies, or because they eve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f7e8d9a06c49ef42e973fc8a84ac5ee2
https://pubmed.ncbi.nlm.nih.gov/28298527
https://pubmed.ncbi.nlm.nih.gov/28298527
Autor:
Sandip Middya, Monali Banerjee, Eduardo Riquelme, Sarvajit Chakravarty, Pankaj Melkani, Vikas Dixit, Felipe Olivares, Shyamraj Yadav, Umesh K. Patil, David T. Hung, Andrew A. Protter, Shailendra Tripathi, Roopa Rai, Javier Sanchez Guerrero, Ashu Gupta, Emma McCullagh, Darren H. Wong, Sebastian Bernales, Ramnivas Jangir, Arjun Surya, Son Minh Pham, Ritesh Shrivastava, Mohd. Raja
Publikováno v:
Bioorganicmedicinal chemistry letters. 26(20)
Temozolomide is a chemotherapeutic agent that is used in the treatment of glioblastoma and other malignant gliomas. It acts through DNA alkylation, but treatment is limited by its systemic toxicity and neutralization of DNA alkylation by upregulation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec1463799bca9c5e511cba537e15c1ca
https://pubmed.ncbi.nlm.nih.gov/27614414
https://pubmed.ncbi.nlm.nih.gov/27614414