Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Emira J. Visser"'
Molecular basis and dual ligand regulation of tetrameric Estrogen Receptor α/14-3-3ζ protein complex
Autor:
Bente A. Somsen, Eline Sijbesma, Seppe Leysen, Karolina Honzejkova, Emira J. Visser, Peter J. Cossar, Tomáš Obšil, Luc Brunsveld, Christian Ottmann
Publikováno v:
Journal of Biological Chemistry. 299(7)
Therapeutic strategies targeting Nuclear Receptors (NRs) beyond their endogenous ligand binding pocket have gained significant scientific interest, driven by a need to circumvent problems associated with drug resistance and pharmacological profile. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f32f0b6d6bc8bcf5e9e850310d323d7c
https://doi.org/10.1016/j.jbc.2023.104855
https://doi.org/10.1016/j.jbc.2023.104855
Autor:
Dyana N. Kenanova, Emira J. Visser, Johanna M. Virta, Eline Sijbesma, Federica Centorrino, Holly R. Vickery, Mengqi Zhong, R. Jeffrey Neitz, Luc Brunsveld, Christian Ottmann, Michelle R. Arkin
Publikováno v:
ACS Central Science, 9(5), 937-946. American Chemical Society
ACS central science, vol 9, iss 5
ACS central science, vol 9, iss 5
Protein-protein interactions (PPIs) are responsible for the proper function of biological processes and, when dysregulated, commonly lead to disease. PPI stabilization has only recently been systematically explored for drug discovery despite being a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73d5dfbb9f85f0ba6a6dbf92e3bacf2b
https://research.tue.nl/nl/publications/076d1025-cb55-4575-b0a2-584f109c7743
https://research.tue.nl/nl/publications/076d1025-cb55-4575-b0a2-584f109c7743
Autor:
Bente A. Somsen, Fenna W. B. Craenmehr, Wei-Hong W. Liu, Auke A. Koops, Marloes A. M. Pennings, Emira J. Visser, Christian Ottmann, Peter J. Cossar, Luc Brunsveld
Publikováno v:
Chemical Science, 13(44), 13122-13131. Royal Society of Chemistry
Molecular glues represent an evolution in drug discovery, however, targeted stabilization of protein complexes remains challenging, owing to a paucity of drug design rules. The functional mapping of hotspots has been critical to protein-protein inter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::095d4e106d3422726216b1eb0e44cc8a