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Akademický článek

Evaluation of mitochondrial biogenesis and ROS generation in high-grade serous ovarian cancer

Autor: Zeynep C. Koc, Vincent E. Sollars, Nadim Bou Zgheib, Gary O. Rankin, Emine C. Koc

Publikováno v: Frontiers in Oncology, Vol 13 (2023)

IntroductionOvarian cancer is one of the leading causes of death for women with cancer worldwide. Energy requirements for tumor growth in epithelial high-grade serous ovarian cancer (HGSOC) are fulfilled by a combination of aerobic glycolysis and oxi

Externí odkaz: https://doaj.org/article/f218794147364829983a3154f0345539

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Akademický článek

Role of mitochondrial translation in remodeling of energy metabolism in ER/PR(+) breast cancer

Autor: Emine C. Koc, Fatih C. Koc, Funda Kartal, Maria Tirona, Hasan Koc

Publikováno v: Frontiers in Oncology, Vol 12 (2022)

Remodeling of mitochondrial energy metabolism is essential for the survival of tumor cells in limited nutrient availability and hypoxic conditions. Defects in oxidative phosphorylation (OXPHOS) and mitochondrial biogenesis also cause a switch in ener

Externí odkaz: https://doaj.org/article/3d474ea12a3d46eab1e6377a484ad2f4

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Phosphorylation of mammalian mitochondrial EF-Tu by Fyn and c-Src kinases

Autor: Emine C, Koc, Caroline A, Hunter, Hasan, Koc

Publikováno v: Cellular Signalling. 101:110524

Src Family Kinases (SFKs) are tyrosine kinases known to regulate glucose and fatty acid metabolism as well as oxidative phosphorylation (OXPHOS) in mammalian mitochondria. We and others discovered the association of the SFK kinases Fyn and c-Src with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b53cc1e417786f6293ec76d7277bbee
https://doi.org/10.1016/j.cellsig.2022.110524

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Mitochondrial localization, import, and mitochondrial function of the androgen receptor

Autor: Keshav K. Singh, Emine C. Koc, Guru Sonpavde, Prachi Bajpai, Rajender Singh

Publikováno v: Journal of Biological Chemistry. 294:6621-6634

Nuclear localization of androgen receptor (AR) directs transcriptional regulation of a host of genes, referred to as genomic signaling. Additionally, nonnuclear or nongenomic activities of the AR have long been described, but understanding of these a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a87325e53fc7964513163666a19423c2
https://doi.org/10.1074/jbc.ra118.006727

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Akademický článek

Identification and Characterization of CHCHD1, AURKAIP1, and CRIF1 as New Members of the Mammalian Mitochondrial Ribosome

Autor: Emine C Koc, Huseyin eCimen, Beril eKumcuoglu, Nadiah eAbu, Gurler eAkpinar, Md Emdadul Haque, Linda L Spremulli, Hasan eKoc

Publikováno v: Frontiers in Physiology, Vol 4 (2013)

Defects in mitochondrial ribosomal proteins (MRPs) cause various diseases in humans. Because of the essential role of MRPs in synthesizing the essential subunits of oxidative phosphorylation (OXPHOS) complexes, identifying all of the protein componen

Externí odkaz: https://doaj.org/article/24dce0ad3e054c9485d8fa20b4af5c10

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c-Src kinase impairs the expression of mitochondrial OXPHOS complexes in liver cancer

Autor: Emine C. Koc, Caroline A. Hunter, Hasan Koc

Publikováno v: Cell Signal

Src family kinases (SFKs) play a crucial role in the regulation of multiple cellular pathways, including mitochondrial oxidative phosphorylation (OXPHOS). Aberrant activities of one of the most predominant SFKs, c-Src, was identified as a fundamental

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e62a1fe2bf3e0d717a95be4588f4ff83
https://europepmc.org/articles/PMC9373045/

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Corrigendum to 'Mitochondrial oxidative phosphorylation is impaired in TALLYHO mice, a new obesity and type 2 diabetes animal model' [Int. J. Biochem. Cell Biol. 116 (2019) 1–11]

Autor: Emine C. Koc, Zeynep C. Koc, Jung Han Kim, Funda Kartal, Tamara Murphy, James Denvir, Caroline A. Hunter

Publikováno v: Int J Biochem Cell Biol

Type 2 diabetes has become an epidemic disease largely explained by the dramatic increase in obesity in recent years. Mitochondrial dysfunction is suggested as an underlying factor in obesity and type 2 diabetes. In this study, we evaluated changes i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd0e225efac33291f951e6944209a798
https://europepmc.org/articles/PMC7439518/

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Mitochondrial oxidative phosphorylation is impaired in TALLYHO mice, a new obesity and type 2 diabetes animal model

Autor: Emine C. Koc, Jung Han Kim, James Denvir, Zeynep C. Koc, Funda Kartal, Tamara Murphy, Caroline A. Hunter

Publikováno v: Int J Biochem Cell Biol

WOS: 000495487400008
PubMed: 31542429
Type 2 diabetes has become an epidemic disease largely explained by the dramatic increase in obesity in recent years. Mitochondrial dysfunction is suggested as an underlying factor in obesity and type 2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc111d168d3335b0ffc65849fa476848
https://hdl.handle.net/11454/63272

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