Zobrazeno 1 - 10
of 117
pro vyhledávání: '"Emily Yang"'
Autor:
Jie Du, Weizhe Chen, Xihua Jia, Xuejiao Xu, Emily Yang, Ruizhi Zhou, Yuqi Zhang, Matt Metzloff, Philipp W. Messer, Jackson Champer
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Gene drive systems could be a viable strategy to prevent pathogen transmission or suppress vector populations by propagating drive alleles with super-Mendelian inheritance. CRISPR-based homing gene drives convert wild type alleles into drive
Externí odkaz:
https://doaj.org/article/7bcc28e1cfff46859f2097068c4cce2c
Autor:
Cecilia Fahlquist-Hagert, Thomas R. Wittenborn, Ewa Terczyńska-Dyla, Kristian Savstrup Kastberg, Emily Yang, Alysa Nicole Rallistan, Quinton Raymond Markett, Gudrun Winther, Sofie Fonager, Lasse F. Voss, Mathias K. Pedersen, Nina van Campen, Alexey Ferapontov, Lisbeth Jensen, Jinrong Huang, John D. Nieland, Cees E. van der Poel, Johan Palmfeldt, Michael C. Carroll, Paul J. Utz, Yonglun Luo, Lin Lin, Søren E. Degn
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Abstract Circumstantial evidence suggests that B cells may instruct T cells to break tolerance. Here, to test this hypothesis, we used a murine model in which a single B cell clone precipitates an autoreactive response resembling systemic lupus eryth
Externí odkaz:
https://doaj.org/article/77b3e9364b6c4ef5993ede3e01fc8946
Autor:
Matthew Metzloff, Emily Yang, Sumit Dhole, Andrew G. Clark, Philipp W. Messer, Jackson Champer
Publikováno v:
BMC Biology, Vol 20, Iss 1, Pp 1-13 (2022)
Abstract Background Homing gene drives hold great promise for the genetic control of natural populations. However, current homing systems are capable of spreading uncontrollably between populations connected by even marginal levels of migration. This
Externí odkaz:
https://doaj.org/article/82e027ed2a8643468a7c8a40fd4bfad1
Autor:
Lauren Grimm, Chinyere Onyeukwu, Grace Kenny, Danielle Parent, Jia Fu, Shaurya Dhingra, Emily Yang, James Moy, PJ Utz, Russell Tracy, Alan Landay
Publikováno v:
Pathogens and Immunity, Vol 7, Iss 2 (2023)
Introduction: Neutralizing antibodies have been shown to develop rapidly following SARS-CoV-2 infection, specifically against spike (S) protein, where cytokine release and production is understood to drive the humoral immune response during acute inf
Externí odkaz:
https://doaj.org/article/843cc0dc016542779ff76520e0052289
Autor:
Emily Yang, Serina Huang, Yasaman Jami-Alahmadi, Gerald M McInerney, James A Wohlschlegel, Melody M H Li
Publikováno v:
PLoS Pathogens, Vol 18, Iss 9, p e1010743 (2022)
The tripartite motif (TRIM) family of E3 ubiquitin ligases is well known for its roles in antiviral restriction and innate immunity regulation, in addition to many other cellular pathways. In particular, TRIM25-mediated ubiquitination affects both ca
Externí odkaz:
https://doaj.org/article/a11b40dc318e4c13b4e16e866a7ae0ec
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
The innate immune response controls the acute phase of virus infections; critical to this response is the induction of type I interferon (IFN) and resultant IFN-stimulated genes to establish an antiviral environment. One such gene, zinc finger antivi
Externí odkaz:
https://doaj.org/article/daedce4d260c4c5ca0222000616a3c7d
Publikováno v:
Viruses, Vol 15, Iss 4, p 830 (2023)
Certain re-emerging alphaviruses, such as chikungunya virus (CHIKV), cause serious disease and widespread epidemics. To develop virus-specific therapies, it is critical to understand the determinants of alphavirus pathogenesis and virulence. One majo
Externí odkaz:
https://doaj.org/article/1805c20e1f6548d1a468e12004173366
Autor:
Emily Yang, Matthew Metzloff, Anna M Langmüller, Xuejiao Xu, Andrew G Clark, Philipp W Messer, Jackson Champer
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 12, Iss 6 (2022)
AbstractGene drives are engineered alleles that can bias inheritance in their favor, allowing them to spread throughout a population. They could potentially be used to modify or suppress pest populations, such as mosquitoes that spread diseases. CRIS
Externí odkaz:
https://doaj.org/article/c93377ff98914cc5924aac77126ae869
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
CRISPR homing gene drives are highly invasive and can fail due to the rapid evolution of resistance. Here the authors present TARE drive, inspired by naturally occurring selfish genetic elements, which is less vulnerable to resistance and can potenti
Externí odkaz:
https://doaj.org/article/8d0e866433494a27b44fe774762e8847
Autor:
Emily Yang, Melody M. H. Li
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Interferon (IFN) signaling induces the expression of a wide array of genes, collectively referred to as IFN-stimulated genes (ISGs) that generally function to inhibit viral replication. RNA viruses are frequently targeted by ISGs through recognition
Externí odkaz:
https://doaj.org/article/5a265a83e09f44409a3678f713442bd7