Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Emily Y. Ko"'
Autor:
Seokjo Kang, Emily Y. Ko, Amelia E. Andrews, Juliana E. Shin, Karina J. Nance, Pijus K. Barman, Peter S. Heeger, Willard M. Freeman, Bérénice A. Benayoun, Helen S. Goodridge
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-14 (2024)
Abstract Microglia, the brain’s resident macrophages, maintain brain homeostasis and respond to injury and infection. During aging they undergo functional changes, but the underlying mechanisms and their contributions to neuroprotection versus neur
Externí odkaz:
https://doaj.org/article/ea800acc967149ce81f4777b84b82d93
Autor:
Marina T. Broz, Emily Y. Ko, Kristin Ishaya, Jinfen Xiao, Marco De Simone, Xen Ping Hoi, Roberta Piras, Basia Gala, Fernando H. G. Tessaro, Anja Karlstaedt, Sandra Orsulic, Amanda W. Lund, Keith Syson Chan, Jlenia Guarnerio
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract T cell-based immunotherapies have exhibited promising outcomes in tumor control; however, their efficacy is limited in immune-excluded tumors. Cancer-associated fibroblasts (CAFs) play a pivotal role in shaping the tumor microenvironment and
Externí odkaz:
https://doaj.org/article/3c3fee63de4c4625909fa4b34fc910c7
Autor:
Roberta Piras, Emily Y. Ko, Connor Barrett, Marco De Simone, Xianzhi Lin, Marina T. Broz, Fernando H. G. Tessaro, Mireia Castillo-Martin, Carlos Cordon-Cardo, Helen S. Goodridge, Dolores Di Vizio, Mona Batish, Kate Lawrenson, Y. Grace Chen, Keith Syson Chan, Jlenia Guarnerio
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Circular RNAs can contribute to tumour progression. Here the authors show that two circular RNAs, circCsnk1g3 and circAnkib1 promote sarcoma growth by controlling the expression of interferon related genes and pro-inflammatory factors in sarcoma cell
Externí odkaz:
https://doaj.org/article/ce63810cc8a74cdea3778e236afde9f9
Autor:
Anthony T. Nguyen, Tahir B. Dar, Jolene Viramontes, Satchel Stevens, Julie K. Jang, Emily Y. Ko, Diana J. Lu, Eric M. Chung, Samuel C. Zhang, Katelyn M. Atkins, Mitchell Kamrava, Howard M. Sandler, Jlenia Guarnerio, Simon Knott, Zachary S. Zumsteg, David M. Underhill, Stephen L. Shiao
Publikováno v:
Cancer Research. 83:6409-6409
Multiple studies have demonstrated synergy between immune checkpoint blockade (ICB) and radiotherapy (RT) in preclinical murine models; however, randomized trials of RT/ICB have been inconsistent in patients with solid tumors. To better understand th
Autor:
Fernando H.G. Tessaro, Emily Y. Ko, Marco De Simone, Roberta Piras, Marina T. Broz, Helen S. Goodridge, Bonnie Balzer, Stephen L. Shiao, Jlenia Guarnerio
Publikováno v:
Cell Reports. 39:110977
The standard of care is unsuccessful to treat recurrent and aggressive soft-tissue sarcomas. Interventions aimed at targeting components of the tumor microenvironment have shown promise for many solid tumors yet have been only marginally tested for s
Autor:
Roberta Piras, Emily Y. Ko, Connor Barrett, Marco De Simone, Xianzhi Lin, Marina T. Broz, Fernando H. G. Tessaro, Mireia Castillo-Martin, Carlos Cordon-Cardo, Helen S. Goodridge, Dolores Di Vizio, Mona Batish, Kate Lawrenson, Y. Grace Chen, Keith Syson Chan, Jlenia Guarnerio
Publikováno v:
Nature communications. 13(1)
Exonic circular RNAs (circRNAs) produce predominantly non-coding RNA species that have been recently profiled in many tumors. However, their functional contribution to cancer progression is still poorly understood. Here, we identify the circRNAs expr
Autor:
Shikha Bose, Emily Y. Ko, Alexander D. Prince, Viviana I. Maymi, Dermot P.B. McGovern, Stephen L. Shiao, Junhee Yoon, Alka A. Potdar, Madison J. Davis, Yuzu Kubota, Kathleen M. Kershaw, Sungyong You, Jie Tang, Jung Lee, Paul Noe, Tahir B. Dar, Jose J. Limon, Matthew Gargus, Zachary S. Zumsteg, Jlenia Guarnerio, David M. Underhill, Rachel Y. Choi, Wensha Yang, Regina M. Henson
Publikováno v:
Cancer Cell
Studies suggest that the efficacy of cancer chemotherapy and immunotherapy is influenced by intestinal bacteria. However, the influence of the microbiome on radiation therapy is not as well understood, and the microbiome comprises more than bacteria.
Autor:
Jacob G. Bernstein, Xue Han, Michael A. Henninger, Emily Y. Ko, Xiaofeng Qian, Giovanni Talei Franzesi, Jackie P. McConnell, Patrick Stern, Robert Desimone, Edward S. Boyden
Publikováno v:
Optical Interactions with Tissue and Cells XIX.
Many neural disorders are associated with aberrant activity in specific cell types or neural projection pathways embedded within the densely-wired, heterogeneous matter of the brain. An ideal therapy would permit correction of activity just in specif