Výsledky vyhledávání - "Emily Wolfrum"

Akademický článek

A diverse proteome is present and enzymatically active in metabolite extracts

Autor: Rachel (Rae) J. House, Molly T. Soper-Hopper, Michael P. Vincent, Abigail E. Ellis, Colt D. Capan, Zachary B. Madaj, Emily Wolfrum, Christine N. Isaguirre, Carlos D. Castello, Amy B. Johnson, Martha L. Escobar Galvis, Kelsey S. Williams, Hyoungjoo Lee, Ryan D. Sheldon

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)

Abstract Metabolite extraction is the critical first-step in metabolomics experiments, where it is generally regarded to inactivate and remove proteins. Here, arising from efforts to improve extraction conditions for polar metabolomics, we discover a

Externí odkaz: https://doaj.org/article/3c2a5db689674347bf92e9f80980aebe

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Akademický článek

Nf1 deficiency modulates the stromal environment in the pretumorigenic rat mammary gland

Autor: Menusha Arumugam, Elizabeth A. Tovar, Curt J. Essenburg, Patrick S. Dischinger, Ian Beddows, Emily Wolfrum, Zach B. Madaj, Lisa Turner, Kristin Feenstra, Kristin L. Gallik, Lorna Cohen, Madison Nichols, Rachel T. C. Sheridan, Corinne R. Esquibel, Ghassan Mouneimne, Carrie R. Graveel, Matthew R. Steensma

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 12 (2024)

Background:Neurofibromin, coded by the NF1 tumor suppressor gene, is the main negative regulator of the RAS pathway and is frequently mutated in various cancers. Women with Neurofibromatosis Type I (NF1)–a tumor predisposition syndrome caused by a

Externí odkaz: https://doaj.org/article/9103489e423e425289d511e159c7326a

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Akademický článek

Heterozygous GBA D409V and ATP13a2 mutations do not exacerbate pathological α-synuclein spread in the prodromal preformed fibrils model in young mice

Autor: Michaela E. Johnson, Liza Bergkvist, Lucas Stetzik, Jennifer A. Steiner, Lindsay Meyerdirk, Emily Schulz, Emily Wolfrum, Kelvin C. Luk, Daniel W. Wesson, Dimitri Krainc, Patrik Brundin

Publikováno v: Neurobiology of Disease, Vol 159, Iss , Pp 105513- (2021)

Autophagic dysregulation and lysosomal impairment have been implicated in the pathogenesis of Parkinson's disease, partly due to the identification of mutations in multiple genes involved in these pathways such as GBA, SNCA, ATP13a2 (also known as PA

Externí odkaz: https://doaj.org/article/623a98fa3aef46ea809f14eccbe44977

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Akademický článek

Pediatric Multi-Organ Dysfunction Syndrome: Analysis by an Untargeted 'Shotgun' Lipidomic Approach Reveals Low-Abundance Plasma Phospholipids and Dynamic Recovery over 8-Day Period, a Single-Center Observational Study

Autor: Mara L. Leimanis-Laurens, Karen Ferguson, Emily Wolfrum, Brian Boville, Dominic Sanfilippo, Todd A. Lydic, Jeremy W. Prokop, Surender Rajasekaran

Publikováno v: Nutrients, Vol 13, Iss 3, p 774 (2021)

Lipids are molecules involved in metabolism and inflammation. This study investigates the plasma lipidome for markers of severity and nutritional status in critically ill children. Children with multi-organ dysfunction syndrome (MODS) (n = 24) are an

Externí odkaz: https://doaj.org/article/fdf3be6d097340b1aea7246e0b3c2c1f

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p53 modulates kinase inhibitor resistance and lineage plasticity in NF1-related MPNSTs

Autor: Jamie L. Grit, Lauren E. McGee, Elizabeth A. Tovar, Curt J. Essenburg, Emily Wolfrum, Ian Beddows, Kaitlin Williams, Rachael Sheridan, Josh Schipper, Marie Adams, Menusha Arumugam, Thomas Vander Woude, Sharavana Gurunathan, Jeffrey M. Field, Julia Wulfkuhle, Emanuel F. Petricoin, Carrie R. Graveel, Matthew R. Steensma

Malignant peripheral nerve sheath tumors (MPNSTs) are chemotherapy resistant sarcomas that are a leading cause of death in neurofibromatosis type 1 (NF1). Although NF1-related MPNSTs derive from neural crest cell origin, they also exhibit intratumora

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ecd95228ddc9c722b3703efd9054ad78
https://doi.org/10.1101/2023.01.18.523629

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Label-Retaining, Putative Mesenchymal Stem Cells Contribute to Murine Myometrial Repair During Uterine Involution

Autor: Anindita Chatterjee, Tyler J. Carpenter, James K. Pru, Amanda L. Patterson, Emily Wolfrum, Jitu W George, José A. Teixeira

Publikováno v: Stem Cells and Development. 27:1715-1728

Uterine remodeling during pregnancy is a fundamental, dynamic process required for successful propagation of eutherian species. The uterus can increase in size up to 40-fold during pregnancy, which is largely attributed to expansion of the myometrium

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68a5b5b1acb7f6fb0332bf537120b6ea
https://doi.org/10.1089/scd.2018.0146

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Hexosylceramides and Glycerophosphatidylcholine GPC(36:1) Increase in Multi-Organ Dysfunction Syndrome Patients with Pediatric Intensive Care Unit Admission over 8-Day Hospitalization

Autor: Jocelyn R. Grunwell, Dominic Sanfilippo, Karen Ferguson, Emily Wolfrum, Todd A. Lydic, Mara L. Leimanis-Laurens, Jeremy W. Prokop, Surender Rajasekaran

Publikováno v: Journal of Personalized Medicine
Volume 11
Issue 5
Journal of Personalized Medicine, Vol 11, Iss 339, p 339 (2021)

Glycero- and sphingo-lipids are important in plasma membrane structure, caloric storage and signaling. An un-targeted lipidomics approach for a cohort of critically ill pediatric intensive care unit (PICU) patients undergoing multi-organ dysfunction

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07f936a2b9d048ce2c7abc5c218f4362

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