Výsledky vyhledávání - "Emily Valentino"

Phase II Multicenter, Open-Label Study of Oral ENMD-2076 for the Treatment of Patients with Advanced Fibrolamellar Carcinoma

Publikováno v: Oncologist

Lessons Learned The fibrolamellar carcinoma-associated DNAJB1-PRKACA gene fusion transcript RNA codes for the catalytic domain of protein kinase A and, thus, overexpression of Aurora kinase A. ENMD-2076 showed a favorable toxicity profile. The limite

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b74e79a584bc1cd0d046f17abf0e344
https://doi.org/10.1634/theoncologist.2020-0093

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Binimetinib plus Gemcitabine and Cisplatin Phase I/II Trial in Patients with Advanced Biliary Cancers

Publikováno v: Clinical Cancer Research. 25:937-945

Purpose: Mutations in the RAS/RAF/MEK/ERK signaling pathway are commonly found in biliary tract cancer (BTC). Binimetinib, a selective inhibitor of MEK1/2, has single-agent activity. Preclinical data support binimetinib combination with chemotherapy,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d3b7b3970ea145ef6c8293530ef7d7e
https://doi.org/10.1158/1078-0432.ccr-18-1927

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Treatment Response and Outcomes of Grade 3 Pancreatic Neuroendocrine Neoplasms Based on Morphology

Autor: Peter J. Allen, Brian R. Untch, Emily Valentino, Olca Basturk, Nitya Raj, Laura H. Tang, Marinela Capanu, David S. Klimstra, Diane Reidy-Lagunes

Publikováno v: Pancreas. 46:296-301

Emerging data suggest that not all grade 3 (G3) pancreatic neuroendocrine neoplasms (panNENs) behave the same; tumor differentiation may predict outcome.Patients with G3 panNENs treated at our institution between 1999 and 2014 were identified. Demogr

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https://doi.org/10.1097/mpa.0000000000000735

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ADI-PEG 20 and FOLFOX6: A phase 1 study in pts (pts) with advanced hepatocellular carcinoma (HCC)

Autor: Khrystyna Uhlitskykh, James J. Harding, Ghassan K. Abou-Alfa, Xiaoxing Feng, Eileen M. O'Reilly, Jessica Frick, John S. Bomalaski, Richard K. G. Do, Ellen Hollywood, Casey R. Hamilton, Emily Valentino, Peter Justin Wan, Chien-Feng Li, Amanda Johnston

Publikováno v: Journal of Clinical Oncology. 36:4085-4085

4085Background: Arginine depletion interferes with pyrimidine metabolism as well as DNA damage repair pathways, and preclinical data indicate that pairing pegylated arginine deaminase (ADI-PEG 20) ...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b0ca61ba936e0b63842b42a49fea68ed
https://doi.org/10.1200/jco.2018.36.15_suppl.4085

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Molecular landscape of fibrolamellar carcinoma (FLC): Beyond the DNAJB1-PRKACA chimera

Autor: James J. Harding, Emily Valentino, Ghassan K. Abou-Alfa, Marinela Capanu, Ryma Benayed, Maria E. Arcila, Imane El Dika, Leonard B. Saltz, Michael F. Berger, Eileen M. O'Reilly, Matthew Rusek

Publikováno v: Journal of Clinical Oncology. 35:e15668-e15668

e15668 Background: FLC is a rare cancer arising in non-cirrhotic liver of young adults. A functional chimeric transcript resulting from the in-frame fusion of DNAJB1 with PRKACA genes on chromosome 19 is thought to be universal and unique in FLC. Thi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9ba505357bb7ec0b6a10bb56480b348b
https://doi.org/10.1200/jco.2017.35.15_suppl.e15668

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Next-generation sequencing (NGS) in advanced well differentiated pancreatic neuroendocrine tumors (WD pNETs): A study using MSK-IMPACT

Autor: Diane Lauren Reidy, Jaclyn F. Hechtman, Tara Soumerai, Nitya Raj, Michael F. Berger, Emily Valentino

Publikováno v: Journal of Clinical Oncology. 34:e15661-e15661

246 Background: Whole exome sequencing in WD pNETs demonstrated an increased number of mutations in chromatin modeling genes (MEN1, DAXX, and ATRX), and in the mTOR pathway. NGS brings this technology to the clinic but its relevance in practice has b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::855b754f8ac907aa75e9e3be3340a1b9
https://doi.org/10.1200/jco.2016.34.15_suppl.e15661

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Low objective response and high toxicity to single-agent mitotane in patients with metastatic adrenocortical carcinoma (ACC): A 25 year experience at MSKCC

Autor: Scott R. Gerst, Leonard B. Saltz, Seth S. Katz, Diane Lauren Reidy, Betty Y Lung, Kelly Olino, Emily Valentino, Brian R. Untch, Nitya Raj, Vivian E. Strong

Publikováno v: Journal of Clinical Oncology. 33:4105-4105

4105 Background: ACC is a rare but devastating disease, with short life expectancy in the setting of metastatic, unresectable disease. Mitotane, an oral adrenocorticolytic agent, is often used as a systemic treatment though its therapeutic window is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eafa11186a7eebc2768a7b2653eb1d9b
https://doi.org/10.1200/jco.2015.33.15_suppl.4105

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Treatment response and outcomes of grade 3 (G3) pancreatic neuroendocrine carcinomas (HGNEC) based on pathologic differentiation

Autor: Emily Valentino, Nitya Raj, Laura H. Tang, David S. Klimstra, Marinela Capanu, Diane Lauren Reidy, Olca Basturk

Publikováno v: Journal of Clinical Oncology. 33:e15185-e15185

e15185 Background: World Health Organization criteria define HGNEC as neuroendocrine tumors with Ki-67 index > 20%. However, it is unknown if treatment response and/or outcomes vary based on cellul...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0936aa16017362f88bfa75e1bda1b513
https://doi.org/10.1200/jco.2015.33.15_suppl.e15185

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