Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Emily T Jarrell"'
Autor:
Lewis C. Cantley, George N. Naumov, John V. Heymach, Ana M. Borras, Bruce E. Johnson, Christopher Michael Gale, Toru Mukohara, Emily T Jarrell, Beow Y. Yeap, Pasi A. Jänne, Jeffrey A. Engelman, Jason Sun, Kreshnik Zejnullahu, Sean Tracy, Xiaojun Zhao, Eugene Lifshits
Publikováno v:
Journal of Clinical Investigation. 116:2695-2706
EGFR is frequently mutated and amplified in lung adenocarcinomas sensitive to EGFR inhibitors gefitinib and erlotinib. A secondary mutation, T790M, has been associated with acquired resistance but has not been shown to be sufficient to render EGFR mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4505db1746fa10a86c973b6ef42671d8
https://doi.org/10.1172/jci28656
https://doi.org/10.1172/jci28656
Autor:
Benjamin E. Turk, Robert C. Liddington, Lewis C. Cantley, Thiang Yian Wong, Stephen H. Leppla, R. John Collier, Emily T Jarrell, Robert Schwarzenbacher
Publikováno v:
Nature Structural & Molecular Biology. 11:60-66
Recent events have created an urgent need for new therapeutic strategies to treat anthrax. We have applied a mixture-based peptide library approach to rapidly determine the optimal peptide substrate for the anthrax lethal factor (LF), a metalloprotei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6be5daa4a4d194a361969187ca0330c
https://doi.org/10.1038/nsmb708
https://doi.org/10.1038/nsmb708
Autor:
Victoria H. Cowling, L. Miguel Martins, Benjamin E. Turk, Annabel Borg, Julian Downward, Lewis C. Cantley, Emily T Jarrell
Publikováno v:
Journal of Biological Chemistry. 278:49417-49427
Inhibitor of apoptosis proteins (IAPs) prevent apoptosis through direct inhibition of caspases. The serine protease HtrA2/Omi has an amino-terminal IAP interaction motif like that found in Reaper, which displaces IAPs from caspases, leading to enhanc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f56c220506c9e4d0e1fe77a8eb51587
https://doi.org/10.1074/jbc.m308659200
https://doi.org/10.1074/jbc.m308659200
Autor:
Jessica E. Hutti, Alex Toker, Lewis C. Cantley, James Chang, Peter Storz, Derek W. Abbott, Benjamin E. Turk, Emily T Jarrell
Publikováno v:
Nature Methods. 1:27-29
Selection of target substrates by protein kinases is strongly influenced by the amino acid sequence surrounding the phosphoacceptor site. Identification of the preferred peptide phosphorylation motif for a given kinase permits the production of effic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ca1e2ddafc93e2cf0db592042810c43
https://doi.org/10.1038/nmeth708
https://doi.org/10.1038/nmeth708